Applications of nanomaterials in Neisseria meningitidis infection
Introduction: Neisseria meningitidis is a bacterium that causes meningitis, a potentially fatal and irreversible disease. Current management of the infection is inefficient treatment based on antibiotics, and is influenced by several factors including the time taken to eliminate the causal agent, pr...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Neurology Perspectives |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667049621000806 |
| _version_ | 1797526224747102208 |
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| author | I. Yañez-Sánchez B.C. Zamarripa-Pérez F.J. Gálvez-Gastelum |
| author_facet | I. Yañez-Sánchez B.C. Zamarripa-Pérez F.J. Gálvez-Gastelum |
| author_sort | I. Yañez-Sánchez |
| collection | DOAJ |
| description | Introduction: Neisseria meningitidis is a bacterium that causes meningitis, a potentially fatal and irreversible disease. Current management of the infection is inefficient treatment based on antibiotics, and is influenced by several factors including the time taken to eliminate the causal agent, prevention of recurrent infections, and the difficulty of reaching the infection site and maintaining proper concentrations of the drug after crossing the blood–brain barrier (BBB); therefore, it is essential to develop new pharmacological alternatives capable of crossing the BBB and avoiding antibiotic resistance. To date, little research has been conducted in the development of organic and inorganic nanostructures to facilitate the delivery of antibiotics and other drugs to the target organ across the BBB, and for the diagnóstico of meningitis. Development: We conducted a literature search for nanotechnologies developed for use as direct treatment alternatives against N. meningitidis and to diagnose meningitis caused by this pathogen. We searched various databases and used search engines including NCBI-PubMed and Scopus. The information presented offers a critical overview of the use of nanostructures for antibacterial treatment and diagnóstico. Conclusions: We identified a limited number of nanotechnological advances for the diagnóstico and treatment of N. meningitidis infection. |
| first_indexed | 2024-03-10T09:26:12Z |
| format | Article |
| id | doaj.art-fafeab3d37ef47b88700b601a6a760d7 |
| institution | Directory Open Access Journal |
| issn | 2667-0496 |
| language | English |
| last_indexed | 2024-03-10T09:26:12Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurology Perspectives |
| spelling | doaj.art-fafeab3d37ef47b88700b601a6a760d72023-11-22T04:49:23ZengElsevierNeurology Perspectives2667-04962022-01-012S43S48Applications of nanomaterials in Neisseria meningitidis infectionI. Yañez-Sánchez0B.C. Zamarripa-Pérez1F.J. Gálvez-Gastelum2Centro de Investigación en Nanociencias y Nanotecnología, Departamento de Ciencias Naturales y Exactas, CUValles, Universidad de Guadalajara, Carretera Guadalajara-Ameca Km 45.5, CP 46600, Jalisco, MexicoLaboratorio de Patología, Departamento de Microbiología y Patología, CUCS, Universidad de Guadalajara, Sierra Mojada 950, Col. Independencia, CP44340, Guadalajara, Jalisco, MexicoLaboratorio de Patología, Departamento de Microbiología y Patología, CUCS, Universidad de Guadalajara, Sierra Mojada 950, Col. Independencia, CP44340, Guadalajara, Jalisco, Mexico; Corresponding author.Introduction: Neisseria meningitidis is a bacterium that causes meningitis, a potentially fatal and irreversible disease. Current management of the infection is inefficient treatment based on antibiotics, and is influenced by several factors including the time taken to eliminate the causal agent, prevention of recurrent infections, and the difficulty of reaching the infection site and maintaining proper concentrations of the drug after crossing the blood–brain barrier (BBB); therefore, it is essential to develop new pharmacological alternatives capable of crossing the BBB and avoiding antibiotic resistance. To date, little research has been conducted in the development of organic and inorganic nanostructures to facilitate the delivery of antibiotics and other drugs to the target organ across the BBB, and for the diagnóstico of meningitis. Development: We conducted a literature search for nanotechnologies developed for use as direct treatment alternatives against N. meningitidis and to diagnose meningitis caused by this pathogen. We searched various databases and used search engines including NCBI-PubMed and Scopus. The information presented offers a critical overview of the use of nanostructures for antibacterial treatment and diagnóstico. Conclusions: We identified a limited number of nanotechnological advances for the diagnóstico and treatment of N. meningitidis infection.http://www.sciencedirect.com/science/article/pii/S2667049621000806MeningitisNeisseriananostructuresdiagnósticotreatmentblood–brain barrier |
| spellingShingle | I. Yañez-Sánchez B.C. Zamarripa-Pérez F.J. Gálvez-Gastelum Applications of nanomaterials in Neisseria meningitidis infection Neurology Perspectives Meningitis Neisseria nanostructures diagnóstico treatment blood–brain barrier |
| title | Applications of nanomaterials in Neisseria meningitidis infection |
| title_full | Applications of nanomaterials in Neisseria meningitidis infection |
| title_fullStr | Applications of nanomaterials in Neisseria meningitidis infection |
| title_full_unstemmed | Applications of nanomaterials in Neisseria meningitidis infection |
| title_short | Applications of nanomaterials in Neisseria meningitidis infection |
| title_sort | applications of nanomaterials in neisseria meningitidis infection |
| topic | Meningitis Neisseria nanostructures diagnóstico treatment blood–brain barrier |
| url | http://www.sciencedirect.com/science/article/pii/S2667049621000806 |
| work_keys_str_mv | AT iyanezsanchez applicationsofnanomaterialsinneisseriameningitidisinfection AT bczamarripaperez applicationsofnanomaterialsinneisseriameningitidisinfection AT fjgalvezgastelum applicationsofnanomaterialsinneisseriameningitidisinfection |