Diversity and Comparison of Intestinal <i>Desulfovibrio</i> in Patients with Liver Cirrhosis and Healthy People
<i>Desulfovibrio</i> belongs to Sulfate-reducing bacteria (SRB), which are widely present in anaerobic environments, including the human gut. <i>Desulfovibrio</i> has been associated with many human diseases, including chronic liver disease. However, the characteristics and d...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/11/2/276 |
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| author | Gexue Lu Yu Zhang Yilin Ren Jin-Song Shi Zheng-Hong Xu Yan Geng |
| author_facet | Gexue Lu Yu Zhang Yilin Ren Jin-Song Shi Zheng-Hong Xu Yan Geng |
| author_sort | Gexue Lu |
| collection | DOAJ |
| description | <i>Desulfovibrio</i> belongs to Sulfate-reducing bacteria (SRB), which are widely present in anaerobic environments, including the human gut. <i>Desulfovibrio</i> has been associated with many human diseases, including chronic liver disease. However, the characteristics and difference of <i>Desulfovibrio</i> from fecal samples of healthy volunteers (HV) and patients with liver cirrhosis (LC) have not been fully elucidated. Here, we isolated <i>Desulfovibrio</i> from the feces of 6 HV and 9 LC, and 88 <i>Desulfovibrio</i> strains were obtained. In the feces of HV, 55% of isolated strains were <i>D. desulfuricans</i>, followed by <i>D. intestinalis</i> (15%), D. <i>simplex</i> (11%), <i>D. piger</i> (9%), <i>D. legallii</i> (4%), <i>Cupidesulfovibrio oxamicus</i> (4%) and <i>D. fairfieldensis</i> (2%). However, only <i>D. desulfuricans</i> (60%) and <i>C. oxamicus</i> (40%) were isolated from fecal samples of patients with LC. Our results suggest that there was a significant difference in the desulfurization ability and the H<sub>2</sub>S production ability of different <i>Desulfovibrio</i>. <i>Desulfovibrio</i>. Furthermore, we found that <i>Desulfovibrio</i> isolated from the patients with LC generally had a higher hydrogen sulfide production capacity, gastrointestinal tolerance, and levels of antibiotic resistance than the same species isolated from HV. Our findings suggested that <i>Desulfovibrio</i> may be associated with the occurrence and development of liver cirrhosis. |
| first_indexed | 2024-03-11T08:24:47Z |
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| language | English |
| last_indexed | 2024-03-11T08:24:47Z |
| publishDate | 2023-01-01 |
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| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-faff8ac112804854b6c4f05087b96adc2023-11-16T22:13:41ZengMDPI AGMicroorganisms2076-26072023-01-0111227610.3390/microorganisms11020276Diversity and Comparison of Intestinal <i>Desulfovibrio</i> in Patients with Liver Cirrhosis and Healthy PeopleGexue Lu0Yu Zhang1Yilin Ren2Jin-Song Shi3Zheng-Hong Xu4Yan Geng5School of Life Sciences and Health Engineering, Jiangnan University, No. 1800 Lihu Avenue, Wuxi 214122, ChinaSchool of Life Sciences and Health Engineering, Jiangnan University, No. 1800 Lihu Avenue, Wuxi 214122, ChinaDepartment of Gastroenterology, Affiliated Hospital of Jiangnan University, Wuxi 214122, ChinaSchool of Life Sciences and Health Engineering, Jiangnan University, No. 1800 Lihu Avenue, Wuxi 214122, ChinaNational Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, ChinaSchool of Life Sciences and Health Engineering, Jiangnan University, No. 1800 Lihu Avenue, Wuxi 214122, China<i>Desulfovibrio</i> belongs to Sulfate-reducing bacteria (SRB), which are widely present in anaerobic environments, including the human gut. <i>Desulfovibrio</i> has been associated with many human diseases, including chronic liver disease. However, the characteristics and difference of <i>Desulfovibrio</i> from fecal samples of healthy volunteers (HV) and patients with liver cirrhosis (LC) have not been fully elucidated. Here, we isolated <i>Desulfovibrio</i> from the feces of 6 HV and 9 LC, and 88 <i>Desulfovibrio</i> strains were obtained. In the feces of HV, 55% of isolated strains were <i>D. desulfuricans</i>, followed by <i>D. intestinalis</i> (15%), D. <i>simplex</i> (11%), <i>D. piger</i> (9%), <i>D. legallii</i> (4%), <i>Cupidesulfovibrio oxamicus</i> (4%) and <i>D. fairfieldensis</i> (2%). However, only <i>D. desulfuricans</i> (60%) and <i>C. oxamicus</i> (40%) were isolated from fecal samples of patients with LC. Our results suggest that there was a significant difference in the desulfurization ability and the H<sub>2</sub>S production ability of different <i>Desulfovibrio</i>. <i>Desulfovibrio</i>. Furthermore, we found that <i>Desulfovibrio</i> isolated from the patients with LC generally had a higher hydrogen sulfide production capacity, gastrointestinal tolerance, and levels of antibiotic resistance than the same species isolated from HV. Our findings suggested that <i>Desulfovibrio</i> may be associated with the occurrence and development of liver cirrhosis.https://www.mdpi.com/2076-2607/11/2/276<i>Desulfovibrio</i>gut microbiotachronic liver diseasehydrogen sulfideantibioticsSulfate-reducing bacteria |
| spellingShingle | Gexue Lu Yu Zhang Yilin Ren Jin-Song Shi Zheng-Hong Xu Yan Geng Diversity and Comparison of Intestinal <i>Desulfovibrio</i> in Patients with Liver Cirrhosis and Healthy People Microorganisms <i>Desulfovibrio</i> gut microbiota chronic liver disease hydrogen sulfide antibiotics Sulfate-reducing bacteria |
| title | Diversity and Comparison of Intestinal <i>Desulfovibrio</i> in Patients with Liver Cirrhosis and Healthy People |
| title_full | Diversity and Comparison of Intestinal <i>Desulfovibrio</i> in Patients with Liver Cirrhosis and Healthy People |
| title_fullStr | Diversity and Comparison of Intestinal <i>Desulfovibrio</i> in Patients with Liver Cirrhosis and Healthy People |
| title_full_unstemmed | Diversity and Comparison of Intestinal <i>Desulfovibrio</i> in Patients with Liver Cirrhosis and Healthy People |
| title_short | Diversity and Comparison of Intestinal <i>Desulfovibrio</i> in Patients with Liver Cirrhosis and Healthy People |
| title_sort | diversity and comparison of intestinal i desulfovibrio i in patients with liver cirrhosis and healthy people |
| topic | <i>Desulfovibrio</i> gut microbiota chronic liver disease hydrogen sulfide antibiotics Sulfate-reducing bacteria |
| url | https://www.mdpi.com/2076-2607/11/2/276 |
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