MicroRNAs in prostate cancer
MicroRNAs (miRNAs) are made up of -22 endogenous nucleotides and are small, noncoding RNAs that are important regulators of gene expression at the posttranscriptional level by degrading or repressing target miRNAs. miRNA expression profiles can be used for the detection of diagnostic and prognostic...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2013-03-01
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| Series: | Prostate International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2287888215300088 |
| _version_ | 1797722942456463360 |
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| author | Won Tae Kim Wun-Jae Kim |
| author_facet | Won Tae Kim Wun-Jae Kim |
| author_sort | Won Tae Kim |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are made up of -22 endogenous nucleotides and are small, noncoding RNAs that are important regulators of gene expression at the posttranscriptional level by degrading or repressing target miRNAs. miRNA expression profiles can be used for the detection of diagnostic and prognostic markers for various cancers. Also, alterations of miRNAs in cancer tissues have been associated with clinicopathological parameters. Along with circulating miRNAs, tissue miRNAs have shown promise as markers that can predict cancer recurrence and/or the potential for survival of cancer patients. Additionally, some miRNAs have therapeutic potential. In this review, we discuss and assess the usefulness of tissue-derived and circulating miRNAs for the diagnosis and prognosis of prostate cancer. |
| first_indexed | 2024-03-12T09:55:02Z |
| format | Article |
| id | doaj.art-fb019b510aa84f9a82050393856fa64d |
| institution | Directory Open Access Journal |
| issn | 2287-8882 |
| language | English |
| last_indexed | 2024-03-12T09:55:02Z |
| publishDate | 2013-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Prostate International |
| spelling | doaj.art-fb019b510aa84f9a82050393856fa64d2023-09-02T12:18:05ZengElsevierProstate International2287-88822013-03-01113910.12954/PI.12011MicroRNAs in prostate cancerWon Tae KimWun-Jae KimMicroRNAs (miRNAs) are made up of -22 endogenous nucleotides and are small, noncoding RNAs that are important regulators of gene expression at the posttranscriptional level by degrading or repressing target miRNAs. miRNA expression profiles can be used for the detection of diagnostic and prognostic markers for various cancers. Also, alterations of miRNAs in cancer tissues have been associated with clinicopathological parameters. Along with circulating miRNAs, tissue miRNAs have shown promise as markers that can predict cancer recurrence and/or the potential for survival of cancer patients. Additionally, some miRNAs have therapeutic potential. In this review, we discuss and assess the usefulness of tissue-derived and circulating miRNAs for the diagnosis and prognosis of prostate cancer.http://www.sciencedirect.com/science/article/pii/S2287888215300088Prostatic neoplasmsMicroRNAsBiological markers |
| spellingShingle | Won Tae Kim Wun-Jae Kim MicroRNAs in prostate cancer Prostate International Prostatic neoplasms MicroRNAs Biological markers |
| title | MicroRNAs in prostate cancer |
| title_full | MicroRNAs in prostate cancer |
| title_fullStr | MicroRNAs in prostate cancer |
| title_full_unstemmed | MicroRNAs in prostate cancer |
| title_short | MicroRNAs in prostate cancer |
| title_sort | micrornas in prostate cancer |
| topic | Prostatic neoplasms MicroRNAs Biological markers |
| url | http://www.sciencedirect.com/science/article/pii/S2287888215300088 |
| work_keys_str_mv | AT wontaekim micrornasinprostatecancer AT wunjaekim micrornasinprostatecancer |