Competitive release of drug resistance following drug treatment of mixed <it>Plasmodium chabaudi </it>infections
<p>Abstract</p> <p>Background</p> <p>Malaria infections are often genetically diverse, potentially leading to competition between co-infecting strains. Such competition is of key importance in the spread of drug resistance.</p> <p>Methods</p> <p>...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2004-09-01
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| Series: | Malaria Journal |
| Online Access: | http://www.malariajournal.com/content/3/1/33 |
| _version_ | 1811252726985654272 |
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| author | Read Andrew F Bell Andrew S Culleton Richard de Roode Jacobus C |
| author_facet | Read Andrew F Bell Andrew S Culleton Richard de Roode Jacobus C |
| author_sort | Read Andrew F |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Malaria infections are often genetically diverse, potentially leading to competition between co-infecting strains. Such competition is of key importance in the spread of drug resistance.</p> <p>Methods</p> <p>The effects of drug treatment on within-host competition were studied using the rodent malaria <it>Plasmodium chabaudi</it>. Mice were infected simultaneously with a drug-resistant and a drug-sensitive clone and were then either drug-treated or left untreated. Transmission was assessed by feeding mice to <it>Anopheles stephensi </it>mosquitoes.</p> <p>Results</p> <p>In the absence of drugs, the sensitive clone competitively suppressed the resistant clone; this resulted in lower asexual parasite densities and also reduced transmission to the mosquito vector. Drug treatment, however, allowed the resistant clone to fill the ecological space emptied by the removal of the sensitive clone, allowing it to transmit as well as it would have done in the absence of competition.</p> <p>Conclusion</p> <p>These results show that under drug pressure, resistant strains can have two advantages: (1) they survive better than sensitive strains and (2) they can exploit the opportunities presented by the removal of their competitors. When mixed infections are common, such effects could increase the spread of drug resistance.</p> |
| first_indexed | 2024-04-12T16:39:02Z |
| format | Article |
| id | doaj.art-fb0297d72adb428aa9422f80436e10d5 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-04-12T16:39:02Z |
| publishDate | 2004-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-fb0297d72adb428aa9422f80436e10d52022-12-22T03:24:52ZengBMCMalaria Journal1475-28752004-09-01313310.1186/1475-2875-3-33Competitive release of drug resistance following drug treatment of mixed <it>Plasmodium chabaudi </it>infectionsRead Andrew FBell Andrew SCulleton Richardde Roode Jacobus C<p>Abstract</p> <p>Background</p> <p>Malaria infections are often genetically diverse, potentially leading to competition between co-infecting strains. Such competition is of key importance in the spread of drug resistance.</p> <p>Methods</p> <p>The effects of drug treatment on within-host competition were studied using the rodent malaria <it>Plasmodium chabaudi</it>. Mice were infected simultaneously with a drug-resistant and a drug-sensitive clone and were then either drug-treated or left untreated. Transmission was assessed by feeding mice to <it>Anopheles stephensi </it>mosquitoes.</p> <p>Results</p> <p>In the absence of drugs, the sensitive clone competitively suppressed the resistant clone; this resulted in lower asexual parasite densities and also reduced transmission to the mosquito vector. Drug treatment, however, allowed the resistant clone to fill the ecological space emptied by the removal of the sensitive clone, allowing it to transmit as well as it would have done in the absence of competition.</p> <p>Conclusion</p> <p>These results show that under drug pressure, resistant strains can have two advantages: (1) they survive better than sensitive strains and (2) they can exploit the opportunities presented by the removal of their competitors. When mixed infections are common, such effects could increase the spread of drug resistance.</p>http://www.malariajournal.com/content/3/1/33 |
| spellingShingle | Read Andrew F Bell Andrew S Culleton Richard de Roode Jacobus C Competitive release of drug resistance following drug treatment of mixed <it>Plasmodium chabaudi </it>infections Malaria Journal |
| title | Competitive release of drug resistance following drug treatment of mixed <it>Plasmodium chabaudi </it>infections |
| title_full | Competitive release of drug resistance following drug treatment of mixed <it>Plasmodium chabaudi </it>infections |
| title_fullStr | Competitive release of drug resistance following drug treatment of mixed <it>Plasmodium chabaudi </it>infections |
| title_full_unstemmed | Competitive release of drug resistance following drug treatment of mixed <it>Plasmodium chabaudi </it>infections |
| title_short | Competitive release of drug resistance following drug treatment of mixed <it>Plasmodium chabaudi </it>infections |
| title_sort | competitive release of drug resistance following drug treatment of mixed it plasmodium chabaudi it infections |
| url | http://www.malariajournal.com/content/3/1/33 |
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