Aerosol and Contact Transmission Following Intranasal Infection of Mice with Japanese Encephalitis Virus
The Japanese encephalitis virus (JEV), a causative agent of severe viral encephalitis in humans, has a biological cycle fluctuating between transmission in mosquitoes and avian species and amplification in pigs. Contact transmission of JEV was recently shown in pigs in the absence of arthropod vecto...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-01-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/11/1/87 |
| _version_ | 1798045084934995968 |
|---|---|
| author | Chunxia Chai Rachel Palinski Yixuan Xu Qiao Wang Sanjie Cao Yi Geng Qin Zhao Yiping Wen Xiaobo Huang Qiguai Yan Xiaoping Ma Xintian Wen Yong Huang Xinfeng Han Wenjun Ma Rui Wu |
| author_facet | Chunxia Chai Rachel Palinski Yixuan Xu Qiao Wang Sanjie Cao Yi Geng Qin Zhao Yiping Wen Xiaobo Huang Qiguai Yan Xiaoping Ma Xintian Wen Yong Huang Xinfeng Han Wenjun Ma Rui Wu |
| author_sort | Chunxia Chai |
| collection | DOAJ |
| description | The Japanese encephalitis virus (JEV), a causative agent of severe viral encephalitis in humans, has a biological cycle fluctuating between transmission in mosquitoes and avian species and amplification in pigs. Contact transmission of JEV was recently shown in pigs in the absence of arthropod vectors. Here, we show JEV transmission between infected and contact mice and further demonstrate that JEV transmission occurs between animals via aerosols, as both viral RNA and infectious JEV were detected in direct contact- and aerosol-exposed contact animals. The results of this study change our understanding of JEV transmission in densely populated regions and may help to explain JEV outbreaks without the presence of arthropod vectors. |
| first_indexed | 2024-04-11T23:14:52Z |
| format | Article |
| id | doaj.art-fb02b442f0a74022ba77107133f7fe45 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-11T23:14:52Z |
| publishDate | 2019-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-fb02b442f0a74022ba77107133f7fe452022-12-22T03:57:39ZengMDPI AGViruses1999-49152019-01-011118710.3390/v11010087v11010087Aerosol and Contact Transmission Following Intranasal Infection of Mice with Japanese Encephalitis VirusChunxia Chai0Rachel Palinski1Yixuan Xu2Qiao Wang3Sanjie Cao4Yi Geng5Qin Zhao6Yiping Wen7Xiaobo Huang8Qiguai Yan9Xiaoping Ma10Xintian Wen11Yong Huang12Xinfeng Han13Wenjun Ma14Rui Wu15Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaDepartment of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USAResearch Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaResearch Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaResearch Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaResearch Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaResearch Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaResearch Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaResearch Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaResearch Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaResearch Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaResearch Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaResearch Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaDepartment of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USAResearch Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaThe Japanese encephalitis virus (JEV), a causative agent of severe viral encephalitis in humans, has a biological cycle fluctuating between transmission in mosquitoes and avian species and amplification in pigs. Contact transmission of JEV was recently shown in pigs in the absence of arthropod vectors. Here, we show JEV transmission between infected and contact mice and further demonstrate that JEV transmission occurs between animals via aerosols, as both viral RNA and infectious JEV were detected in direct contact- and aerosol-exposed contact animals. The results of this study change our understanding of JEV transmission in densely populated regions and may help to explain JEV outbreaks without the presence of arthropod vectors.https://www.mdpi.com/1999-4915/11/1/87JEVcontact transmissionaerosol transmissionintranasal infectionmice |
| spellingShingle | Chunxia Chai Rachel Palinski Yixuan Xu Qiao Wang Sanjie Cao Yi Geng Qin Zhao Yiping Wen Xiaobo Huang Qiguai Yan Xiaoping Ma Xintian Wen Yong Huang Xinfeng Han Wenjun Ma Rui Wu Aerosol and Contact Transmission Following Intranasal Infection of Mice with Japanese Encephalitis Virus Viruses JEV contact transmission aerosol transmission intranasal infection mice |
| title | Aerosol and Contact Transmission Following Intranasal Infection of Mice with Japanese Encephalitis Virus |
| title_full | Aerosol and Contact Transmission Following Intranasal Infection of Mice with Japanese Encephalitis Virus |
| title_fullStr | Aerosol and Contact Transmission Following Intranasal Infection of Mice with Japanese Encephalitis Virus |
| title_full_unstemmed | Aerosol and Contact Transmission Following Intranasal Infection of Mice with Japanese Encephalitis Virus |
| title_short | Aerosol and Contact Transmission Following Intranasal Infection of Mice with Japanese Encephalitis Virus |
| title_sort | aerosol and contact transmission following intranasal infection of mice with japanese encephalitis virus |
| topic | JEV contact transmission aerosol transmission intranasal infection mice |
| url | https://www.mdpi.com/1999-4915/11/1/87 |
| work_keys_str_mv | AT chunxiachai aerosolandcontacttransmissionfollowingintranasalinfectionofmicewithjapaneseencephalitisvirus AT rachelpalinski aerosolandcontacttransmissionfollowingintranasalinfectionofmicewithjapaneseencephalitisvirus AT yixuanxu aerosolandcontacttransmissionfollowingintranasalinfectionofmicewithjapaneseencephalitisvirus AT qiaowang aerosolandcontacttransmissionfollowingintranasalinfectionofmicewithjapaneseencephalitisvirus AT sanjiecao aerosolandcontacttransmissionfollowingintranasalinfectionofmicewithjapaneseencephalitisvirus AT yigeng aerosolandcontacttransmissionfollowingintranasalinfectionofmicewithjapaneseencephalitisvirus AT qinzhao aerosolandcontacttransmissionfollowingintranasalinfectionofmicewithjapaneseencephalitisvirus AT yipingwen aerosolandcontacttransmissionfollowingintranasalinfectionofmicewithjapaneseencephalitisvirus AT xiaobohuang aerosolandcontacttransmissionfollowingintranasalinfectionofmicewithjapaneseencephalitisvirus AT qiguaiyan aerosolandcontacttransmissionfollowingintranasalinfectionofmicewithjapaneseencephalitisvirus AT xiaopingma aerosolandcontacttransmissionfollowingintranasalinfectionofmicewithjapaneseencephalitisvirus AT xintianwen aerosolandcontacttransmissionfollowingintranasalinfectionofmicewithjapaneseencephalitisvirus AT yonghuang aerosolandcontacttransmissionfollowingintranasalinfectionofmicewithjapaneseencephalitisvirus AT xinfenghan aerosolandcontacttransmissionfollowingintranasalinfectionofmicewithjapaneseencephalitisvirus AT wenjunma aerosolandcontacttransmissionfollowingintranasalinfectionofmicewithjapaneseencephalitisvirus AT ruiwu aerosolandcontacttransmissionfollowingintranasalinfectionofmicewithjapaneseencephalitisvirus |