Inhibitory effect of benzimidazole derivatives on cholinesterases of animals in the presence of different substrates
Specifically synthesized group of benzimidazole derivatives possessing varying degrees of delocalization of the positive charge in the cation group of the molecule has been studied in order to search for potential cholinergically active compounds and to study the role of the Coulomb interaction in...
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| Format: | Article |
| Language: | English |
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2014-10-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2015/06/Basova_5_14.pdf |
| _version_ | 1827614143580995584 |
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| author | N. E. Basova B. N. Kormilitsyn A. Yu. Perchenok, E. V. Rozengart V. S. Saakov A. A. Suvorov |
| author_facet | N. E. Basova B. N. Kormilitsyn A. Yu. Perchenok, E. V. Rozengart V. S. Saakov A. A. Suvorov |
| author_sort | N. E. Basova |
| collection | DOAJ |
| description | Specifically synthesized group of benzimidazole derivatives possessing varying degrees of delocalization of the positive charge in the cation group of the molecule has been studied in order to search for potential cholinergically active compounds and to study the role of the Coulomb interaction in cholinesterase catalysis. These compounds were reversible inhibitors of cholinesterase (ChE) of human erythrocytes, horse serum, brain of the frog Rana temporaria and visual ganglia of the Pacific squid Todarodes pacificus in the presence of acetylthiocholine iodide and propionylthiocholine iodide as substrates. The differences in the nature of reversible inhibitory effect were observed. The effect of the inhibitor structure and substrate nature, specific for each of the studied inhibitors, on the character of the process of reversible inhibition was found. |
| first_indexed | 2024-03-09T08:50:27Z |
| format | Article |
| id | doaj.art-fb03b2ede9534071ba807b2e68b8f2ae |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-09T08:50:27Z |
| publishDate | 2014-10-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-fb03b2ede9534071ba807b2e68b8f2ae2023-12-02T14:35:56ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032014-10-01865475510.15407/ubj86.05.047Inhibitory effect of benzimidazole derivatives on cholinesterases of animals in the presence of different substratesN. E. Basova0B. N. Kormilitsyn1 A. Yu. Perchenok,2E. V. Rozengart3V. S. Saakov4 A. A. Suvorov5Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Science, Saint-Petersburg Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Science, Saint-Petersburg Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Science, Saint-Petersburg Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Science, Saint-Petersburg Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Science, Saint-PetersburgSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Science, Saint-Petersburg Specifically synthesized group of benzimidazole derivatives possessing varying degrees of delocalization of the positive charge in the cation group of the molecule has been studied in order to search for potential cholinergically active compounds and to study the role of the Coulomb interaction in cholinesterase catalysis. These compounds were reversible inhibitors of cholinesterase (ChE) of human erythrocytes, horse serum, brain of the frog Rana temporaria and visual ganglia of the Pacific squid Todarodes pacificus in the presence of acetylthiocholine iodide and propionylthiocholine iodide as substrates. The differences in the nature of reversible inhibitory effect were observed. The effect of the inhibitor structure and substrate nature, specific for each of the studied inhibitors, on the character of the process of reversible inhibition was found.http://ukrbiochemjournal.org/wp-content/uploads/2015/06/Basova_5_14.pdfbenzimidazol reversible inhibitorscholinesterases of animalssubstrates |
| spellingShingle | N. E. Basova B. N. Kormilitsyn A. Yu. Perchenok, E. V. Rozengart V. S. Saakov A. A. Suvorov Inhibitory effect of benzimidazole derivatives on cholinesterases of animals in the presence of different substrates The Ukrainian Biochemical Journal benzimidazol reversible inhibitors cholinesterases of animals substrates |
| title | Inhibitory effect of benzimidazole derivatives on cholinesterases of animals in the presence of different substrates |
| title_full | Inhibitory effect of benzimidazole derivatives on cholinesterases of animals in the presence of different substrates |
| title_fullStr | Inhibitory effect of benzimidazole derivatives on cholinesterases of animals in the presence of different substrates |
| title_full_unstemmed | Inhibitory effect of benzimidazole derivatives on cholinesterases of animals in the presence of different substrates |
| title_short | Inhibitory effect of benzimidazole derivatives on cholinesterases of animals in the presence of different substrates |
| title_sort | inhibitory effect of benzimidazole derivatives on cholinesterases of animals in the presence of different substrates |
| topic | benzimidazol reversible inhibitors cholinesterases of animals substrates |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2015/06/Basova_5_14.pdf |
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