Preparation and physicochemical assessment of hydroxyapatite-gelatin nanoscaffold containing vanilla
Background. Scaffolds are one of the key components of tissue engineering that play an important role in cell growth. The present study aimed to prepare hydroxyapatite-gelatin nanoscaffolds containing vanilla. Methods. In this in vitro examination, the scaffolds were prepared using the precipitation...
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| Format: | Article |
| Language: | fas |
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Tabriz University of Medical Sciences
2021-10-01
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| Series: | مجله پزشکی دانشگاه علوم پزشکی تبریز |
| Subjects: | |
| Online Access: | https://mj.tbzmed.ac.ir/PDF/mj-43-359.pdf |
| _version_ | 1828748921401245696 |
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| author | Solmaz Maleki Dizaj Masumeh Mokhtarpour Sepideh Zununi Vahed Simin Sharifi |
| author_facet | Solmaz Maleki Dizaj Masumeh Mokhtarpour Sepideh Zununi Vahed Simin Sharifi |
| author_sort | Solmaz Maleki Dizaj |
| collection | DOAJ |
| description | Background. Scaffolds are one of the key components of tissue engineering that play an important role in cell growth. The present study aimed to prepare hydroxyapatite-gelatin nanoscaffolds containing vanilla. Methods. In this in vitro examination, the scaffolds were prepared using the precipitation method. Then, vanilla was loaded into the prepared structures. Dynamic light scattering (DLS) and scanning electron microscopy (SEM) were used to evaluate the size and morphology of the scaffold. The surface charge of the scaffold (zeta potential) was also assessed by employing a Zetasizer. The loading of vanilla was evaluated via ultraviolet-visible spectrophotometry at 372 nm. Results. The results showed that the scaffold was well prepared and had good physicochemical properties, including appropriate particle size (110.23±0.42 nm), good particle distribution, high drug loading (65.03± 0.25%), and acceptable suspension stability (zeta potential equal to 36.42±0.80 mV). Descriptive statistics (mean ± SD) were used to report the results. Conclusion. Based on the obtained results of the current study, we suggest that the prepared scaffolds can be used for in vitro and in vivo applications in future studies for tissue engineering. More investigations are needed to test the usefulness of these scaffolds. |
| first_indexed | 2024-12-10T10:44:11Z |
| format | Article |
| id | doaj.art-fb05ebd0036943c7bd487aeb7800fe57 |
| institution | Directory Open Access Journal |
| issn | 2783-2031 2783-204X |
| language | fas |
| last_indexed | 2024-12-10T10:44:11Z |
| publishDate | 2021-10-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | مجله پزشکی دانشگاه علوم پزشکی تبریز |
| spelling | doaj.art-fb05ebd0036943c7bd487aeb7800fe572022-12-22T01:52:13ZfasTabriz University of Medical Sciencesمجله پزشکی دانشگاه علوم پزشکی تبریز2783-20312783-204X2021-10-0143435936710.34172/mj.2021.06227318Preparation and physicochemical assessment of hydroxyapatite-gelatin nanoscaffold containing vanillaSolmaz Maleki Dizaj0Masumeh Mokhtarpour1Sepideh Zununi Vahed2Simin Sharifi3Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Physical Chemistry, University of Tabriz, Tabriz, IranKidney Research Center, Tabriz University of Medical Sciences, Tabriz, IranDental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, IranBackground. Scaffolds are one of the key components of tissue engineering that play an important role in cell growth. The present study aimed to prepare hydroxyapatite-gelatin nanoscaffolds containing vanilla. Methods. In this in vitro examination, the scaffolds were prepared using the precipitation method. Then, vanilla was loaded into the prepared structures. Dynamic light scattering (DLS) and scanning electron microscopy (SEM) were used to evaluate the size and morphology of the scaffold. The surface charge of the scaffold (zeta potential) was also assessed by employing a Zetasizer. The loading of vanilla was evaluated via ultraviolet-visible spectrophotometry at 372 nm. Results. The results showed that the scaffold was well prepared and had good physicochemical properties, including appropriate particle size (110.23±0.42 nm), good particle distribution, high drug loading (65.03± 0.25%), and acceptable suspension stability (zeta potential equal to 36.42±0.80 mV). Descriptive statistics (mean ± SD) were used to report the results. Conclusion. Based on the obtained results of the current study, we suggest that the prepared scaffolds can be used for in vitro and in vivo applications in future studies for tissue engineering. More investigations are needed to test the usefulness of these scaffolds.https://mj.tbzmed.ac.ir/PDF/mj-43-359.pdfgelatinhydroxyapatitenanoscaffoldvanilla |
| spellingShingle | Solmaz Maleki Dizaj Masumeh Mokhtarpour Sepideh Zununi Vahed Simin Sharifi Preparation and physicochemical assessment of hydroxyapatite-gelatin nanoscaffold containing vanilla مجله پزشکی دانشگاه علوم پزشکی تبریز gelatin hydroxyapatite nanoscaffold vanilla |
| title | Preparation and physicochemical assessment of hydroxyapatite-gelatin nanoscaffold containing vanilla |
| title_full | Preparation and physicochemical assessment of hydroxyapatite-gelatin nanoscaffold containing vanilla |
| title_fullStr | Preparation and physicochemical assessment of hydroxyapatite-gelatin nanoscaffold containing vanilla |
| title_full_unstemmed | Preparation and physicochemical assessment of hydroxyapatite-gelatin nanoscaffold containing vanilla |
| title_short | Preparation and physicochemical assessment of hydroxyapatite-gelatin nanoscaffold containing vanilla |
| title_sort | preparation and physicochemical assessment of hydroxyapatite gelatin nanoscaffold containing vanilla |
| topic | gelatin hydroxyapatite nanoscaffold vanilla |
| url | https://mj.tbzmed.ac.ir/PDF/mj-43-359.pdf |
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