Bridging the translational gap: adenosine as a modulator of neuropathic pain in preclinical models and humans
This review aims to analyse the published data on preclinical and human experimental and clinical adenosine modulation for pain management. We summarise the translatability of the adenosine pathway for further drug development and aim to reveal subgroups of pain patients that could benefit from targ...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2023-12-01
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| Series: | Scandinavian Journal of Pain |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/sjpain-2023-0048 |
| _version_ | 1797208473463685120 |
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| author | Arendt-Nielsen Lars Klitgaard Henrik Hansen Stine N. |
| author_facet | Arendt-Nielsen Lars Klitgaard Henrik Hansen Stine N. |
| author_sort | Arendt-Nielsen Lars |
| collection | DOAJ |
| description | This review aims to analyse the published data on preclinical and human experimental and clinical adenosine modulation for pain management. We summarise the translatability of the adenosine pathway for further drug development and aim to reveal subgroups of pain patients that could benefit from targeting the pathway. |
| first_indexed | 2024-04-24T09:39:22Z |
| format | Article |
| id | doaj.art-fb060803b9c6427998699169292a6813 |
| institution | Directory Open Access Journal |
| issn | 1877-8860 1877-8879 |
| language | English |
| last_indexed | 2024-04-24T09:39:22Z |
| publishDate | 2023-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Scandinavian Journal of Pain |
| spelling | doaj.art-fb060803b9c6427998699169292a68132024-04-15T07:42:32ZengDe GruyterScandinavian Journal of Pain1877-88601877-88792023-12-01241e2738310.1515/sjpain-2023-0048Bridging the translational gap: adenosine as a modulator of neuropathic pain in preclinical models and humansArendt-Nielsen Lars0Klitgaard Henrik1Hansen Stine N.2Department of Health Science and Technology, Center for Neuroplasticity and Pain, CNAP, School of Medicine, Aalborg University, Gistrup, DenmarkNEUmiRNA Therapeutics, Copenhagen, DenmarkNEUmiRNA Therapeutics, Copenhagen, DenmarkThis review aims to analyse the published data on preclinical and human experimental and clinical adenosine modulation for pain management. We summarise the translatability of the adenosine pathway for further drug development and aim to reveal subgroups of pain patients that could benefit from targeting the pathway.https://doi.org/10.1515/sjpain-2023-0048adenosineneuropathic paintranslationanimal modelshuman studies |
| spellingShingle | Arendt-Nielsen Lars Klitgaard Henrik Hansen Stine N. Bridging the translational gap: adenosine as a modulator of neuropathic pain in preclinical models and humans Scandinavian Journal of Pain adenosine neuropathic pain translation animal models human studies |
| title | Bridging the translational gap: adenosine as a modulator of neuropathic pain in preclinical models and humans |
| title_full | Bridging the translational gap: adenosine as a modulator of neuropathic pain in preclinical models and humans |
| title_fullStr | Bridging the translational gap: adenosine as a modulator of neuropathic pain in preclinical models and humans |
| title_full_unstemmed | Bridging the translational gap: adenosine as a modulator of neuropathic pain in preclinical models and humans |
| title_short | Bridging the translational gap: adenosine as a modulator of neuropathic pain in preclinical models and humans |
| title_sort | bridging the translational gap adenosine as a modulator of neuropathic pain in preclinical models and humans |
| topic | adenosine neuropathic pain translation animal models human studies |
| url | https://doi.org/10.1515/sjpain-2023-0048 |
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