Biofunctionalization of magnetite nanoparticles with stevioside: effect on the size and thermal behaviour for use in hyperthermia applications
Controlling the magnetic properties of a nanoparticle efficiently via its particle size to achieve optimized heat under alternating magnetic field is the central point for magnetic hyperthermia-mediated cancer therapy (MHCT). Here, we have shown the successful use of stevioside (a natural plant-base...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/02656736.2019.1565787 |
| _version_ | 1818998283253579776 |
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| author | Ruby Gupta Deepika Sharma |
| author_facet | Ruby Gupta Deepika Sharma |
| author_sort | Ruby Gupta |
| collection | DOAJ |
| description | Controlling the magnetic properties of a nanoparticle efficiently via its particle size to achieve optimized heat under alternating magnetic field is the central point for magnetic hyperthermia-mediated cancer therapy (MHCT). Here, we have shown the successful use of stevioside (a natural plant-based glycoside) as a promising biosurfactant to control the magnetic properties of Fe3O4 nanoparticles by controlling the particle size. The biocompatibility and cellular uptake efficiency by rat C6 glioma cells and calorimetric magnetic hyperthermia profile of the nanoparticles were further examined. Our finding suggests superior properties of stevioside-coated magnetite nanoparticles in comparison to polysorbate-80 and oleic acid coated nanomagnets as far as particle size reduction, biocompatibility, hyperthermic effect, and cellular uptake by the glioblastoma cancer cells are concerned. The stevioside-coated nanomagnets exhibiting the maximum temperature rise were further investigated as heating agents in in vitro magnetic hyperthermia experiments (405 kHz, 168 Oe), showing their efficacy to induce cell death of rat C6 glioma cells after 30 min at a target temperature T = 43 °C. |
| first_indexed | 2024-12-20T21:59:04Z |
| format | Article |
| id | doaj.art-fb072e92914c4d3ea3774ab4727f4ff0 |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-12-20T21:59:04Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-fb072e92914c4d3ea3774ab4727f4ff02022-12-21T19:25:23ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572019-01-0136130131110.1080/02656736.2019.15657871565787Biofunctionalization of magnetite nanoparticles with stevioside: effect on the size and thermal behaviour for use in hyperthermia applicationsRuby Gupta0Deepika Sharma1Institute of Nano Science and TechnologyInstitute of Nano Science and TechnologyControlling the magnetic properties of a nanoparticle efficiently via its particle size to achieve optimized heat under alternating magnetic field is the central point for magnetic hyperthermia-mediated cancer therapy (MHCT). Here, we have shown the successful use of stevioside (a natural plant-based glycoside) as a promising biosurfactant to control the magnetic properties of Fe3O4 nanoparticles by controlling the particle size. The biocompatibility and cellular uptake efficiency by rat C6 glioma cells and calorimetric magnetic hyperthermia profile of the nanoparticles were further examined. Our finding suggests superior properties of stevioside-coated magnetite nanoparticles in comparison to polysorbate-80 and oleic acid coated nanomagnets as far as particle size reduction, biocompatibility, hyperthermic effect, and cellular uptake by the glioblastoma cancer cells are concerned. The stevioside-coated nanomagnets exhibiting the maximum temperature rise were further investigated as heating agents in in vitro magnetic hyperthermia experiments (405 kHz, 168 Oe), showing their efficacy to induce cell death of rat C6 glioma cells after 30 min at a target temperature T = 43 °C.http://dx.doi.org/10.1080/02656736.2019.1565787steviosidebiosurfactantmagnetic nanoparticlesmagnetic hyperthermiaglioma |
| spellingShingle | Ruby Gupta Deepika Sharma Biofunctionalization of magnetite nanoparticles with stevioside: effect on the size and thermal behaviour for use in hyperthermia applications International Journal of Hyperthermia stevioside biosurfactant magnetic nanoparticles magnetic hyperthermia glioma |
| title | Biofunctionalization of magnetite nanoparticles with stevioside: effect on the size and thermal behaviour for use in hyperthermia applications |
| title_full | Biofunctionalization of magnetite nanoparticles with stevioside: effect on the size and thermal behaviour for use in hyperthermia applications |
| title_fullStr | Biofunctionalization of magnetite nanoparticles with stevioside: effect on the size and thermal behaviour for use in hyperthermia applications |
| title_full_unstemmed | Biofunctionalization of magnetite nanoparticles with stevioside: effect on the size and thermal behaviour for use in hyperthermia applications |
| title_short | Biofunctionalization of magnetite nanoparticles with stevioside: effect on the size and thermal behaviour for use in hyperthermia applications |
| title_sort | biofunctionalization of magnetite nanoparticles with stevioside effect on the size and thermal behaviour for use in hyperthermia applications |
| topic | stevioside biosurfactant magnetic nanoparticles magnetic hyperthermia glioma |
| url | http://dx.doi.org/10.1080/02656736.2019.1565787 |
| work_keys_str_mv | AT rubygupta biofunctionalizationofmagnetitenanoparticleswithsteviosideeffectonthesizeandthermalbehaviourforuseinhyperthermiaapplications AT deepikasharma biofunctionalizationofmagnetitenanoparticleswithsteviosideeffectonthesizeandthermalbehaviourforuseinhyperthermiaapplications |