A DNA adductome analysis revealed a reduction in the global level of C5-hydroxymethyl-2′-deoxycytidine in the non-tumoral upper urinary tract mucosa of urothelial carcinoma patients

A DNA adductome analysis revealed a reduction in the global level of C5-hydroxymethyl-2′-deoxycytidine in the non-tumoral upper urinary tract mucosa of urothelial carcinoma patients

Abstract Background DNA adducts, covalent modifications to DNA due to exposure to specific carcinogens, cause the mispairing of DNA bases, which ultimately results in DNA mutations. DNA methylation in the promoter region, another type of DNA base modification, alters the DNA transcription process, a...

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Bibliographic Details
Main Authors: Yuto Matsushita, Yuji Iwashita, Shunsuke Ohtsuka, Ippei Ohnishi, Takashi Yamashita, Hideaki Miyake, Haruhiko Sugimura
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Genes and Environment
Subjects:
DNA adduct
DNA adductome
DNA adductomics
C5-hydroxymethyl-2′-deoxycytidine
Renal cell carcinoma
Upper urinary tract urothelial carcinoma
Online Access:https://doi.org/10.1186/s41021-021-00228-9

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