Prevalence and risk factors of Klebsiella spp. in milk samples from dairy cows with mastitis—A global systematic review
IntroductionThe overall prevalence of Klebsiella spp., a group of important zoonotic pathogens, in the global dairy herds and the risk of cross-species transmission between humans and dairy cows remain to be clarified. This systematic review aimed to determine the prevalence of Klebsiella spp. in mi...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.1143257/full |
| _version_ | 1797866066189221888 |
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| author | Jinming Song Wentao Xiang Qi Wang Jiying Yin Tian Tian Qizhu Yang Meng Zhang Guiyang Ge Jianming Li Naichao Diao Fei Liu Kun Shi Ruopeng Cai Rui Du Rui Du Qinglong Gong |
| author_facet | Jinming Song Wentao Xiang Qi Wang Jiying Yin Tian Tian Qizhu Yang Meng Zhang Guiyang Ge Jianming Li Naichao Diao Fei Liu Kun Shi Ruopeng Cai Rui Du Rui Du Qinglong Gong |
| author_sort | Jinming Song |
| collection | DOAJ |
| description | IntroductionThe overall prevalence of Klebsiella spp., a group of important zoonotic pathogens, in the global dairy herds and the risk of cross-species transmission between humans and dairy cows remain to be clarified. This systematic review aimed to determine the prevalence of Klebsiella spp. in milk samples from dairy cows with mastitis worldwide and to assess the factors influencing the prevalence of these strains.MethodsQualified studies published from 2007 to 2021 were retrieved from ScienceDirect, Web of Science, PubMed, WanFang Database, China National Knowledge Infrastructure (CNKI), and VIP Chinese Journal Database. Calculations of prevalence and their 95% confidence intervals (CIs) were performed for all the studies using the Freeman-Tukey double arcsine transformation (PFT).ResultsA total of 79,852 milk samples from 55 manuscripts were examined in this meta-analysis, and 2,478 samples were found to be positive for Klebsiella spp. The pooled prevalence estimates worldwide were 7.95% (95% CI: 6.07%–10.06%), with significant heterogeneity (I2 = 98.8%, p = 0). The sampling period of 2013–2020 had a higher (p < 0.05) Klebsiella-positive proportion of milk samples (12.16%, 95% CI: 8.08%–16.90%) than that of 2007–2012 (3.85%, 95% CI: 2.67%–5.21%), indicating that bovine mastitis caused by Klebsiella may become increasingly prevalent. The risk factors for the high prevalence of Klebsiella in milk samples mainly included: economic development level (developing countries; 11.76%, 95% CI: 8.25%–15.77%), mastitis type (CM; 11.99%, 95% CI: 8.62%–15.79%), and population density (>500 per sq km; 10.28%, 95% CI: 2.73%–21.58%). Additionally, a bivariate meta-regression analysis revealed that the multidrug-resistance (MDR) rate of the epidemic strains was also closely related to economic development level (R2 = 78.87%) and population density (R2 = 87.51%).DiscussionDue to the potential risk of cross-species transmission between humans and cows, the prevalence of mastitis milk-derived Klebsiella and its high MDR rate need to be monitored, especially in developing countries with high population densities. |
| first_indexed | 2024-04-09T23:18:05Z |
| format | Article |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-04-09T23:18:05Z |
| publishDate | 2023-03-01 |
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| series | Frontiers in Veterinary Science |
| spelling | doaj.art-fb09f73c6ce246baa4b301aa57152cc82023-03-22T05:29:28ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-03-011010.3389/fvets.2023.11432571143257Prevalence and risk factors of Klebsiella spp. in milk samples from dairy cows with mastitis—A global systematic reviewJinming Song0Wentao Xiang1Qi Wang2Jiying Yin3Tian Tian4Qizhu Yang5Meng Zhang6Guiyang Ge7Jianming Li8Naichao Diao9Fei Liu10Kun Shi11Ruopeng Cai12Rui Du13Rui Du14Qinglong Gong15College of Animal Science and Technology, Jilin Agricultural University, Changchun, ChinaCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, ChinaCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, ChinaCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, ChinaCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, ChinaCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, ChinaCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, ChinaCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, ChinaCollege of Chinese Medicine Materials, Jilin Agricultural University, Changchun, ChinaCollege of Chinese Medicine Materials, Jilin Agricultural University, Changchun, ChinaCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, ChinaCollege of Chinese Medicine Materials, Jilin Agricultural University, Changchun, ChinaCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, ChinaCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, ChinaCollege of Chinese Medicine Materials, Jilin Agricultural University, Changchun, ChinaCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, ChinaIntroductionThe overall prevalence of Klebsiella spp., a group of important zoonotic pathogens, in the global dairy herds and the risk of cross-species transmission between humans and dairy cows remain to be clarified. This systematic review aimed to determine the prevalence of Klebsiella spp. in milk samples from dairy cows with mastitis worldwide and to assess the factors influencing the prevalence of these strains.MethodsQualified studies published from 2007 to 2021 were retrieved from ScienceDirect, Web of Science, PubMed, WanFang Database, China National Knowledge Infrastructure (CNKI), and VIP Chinese Journal Database. Calculations of prevalence and their 95% confidence intervals (CIs) were performed for all the studies using the Freeman-Tukey double arcsine transformation (PFT).ResultsA total of 79,852 milk samples from 55 manuscripts were examined in this meta-analysis, and 2,478 samples were found to be positive for Klebsiella spp. The pooled prevalence estimates worldwide were 7.95% (95% CI: 6.07%–10.06%), with significant heterogeneity (I2 = 98.8%, p = 0). The sampling period of 2013–2020 had a higher (p < 0.05) Klebsiella-positive proportion of milk samples (12.16%, 95% CI: 8.08%–16.90%) than that of 2007–2012 (3.85%, 95% CI: 2.67%–5.21%), indicating that bovine mastitis caused by Klebsiella may become increasingly prevalent. The risk factors for the high prevalence of Klebsiella in milk samples mainly included: economic development level (developing countries; 11.76%, 95% CI: 8.25%–15.77%), mastitis type (CM; 11.99%, 95% CI: 8.62%–15.79%), and population density (>500 per sq km; 10.28%, 95% CI: 2.73%–21.58%). Additionally, a bivariate meta-regression analysis revealed that the multidrug-resistance (MDR) rate of the epidemic strains was also closely related to economic development level (R2 = 78.87%) and population density (R2 = 87.51%).DiscussionDue to the potential risk of cross-species transmission between humans and cows, the prevalence of mastitis milk-derived Klebsiella and its high MDR rate need to be monitored, especially in developing countries with high population densities.https://www.frontiersin.org/articles/10.3389/fvets.2023.1143257/fullmeta-analysisbovine mastitisKlebsiellamultidrug-resistance (MDR)prevalence |
| spellingShingle | Jinming Song Wentao Xiang Qi Wang Jiying Yin Tian Tian Qizhu Yang Meng Zhang Guiyang Ge Jianming Li Naichao Diao Fei Liu Kun Shi Ruopeng Cai Rui Du Rui Du Qinglong Gong Prevalence and risk factors of Klebsiella spp. in milk samples from dairy cows with mastitis—A global systematic review Frontiers in Veterinary Science meta-analysis bovine mastitis Klebsiella multidrug-resistance (MDR) prevalence |
| title | Prevalence and risk factors of Klebsiella spp. in milk samples from dairy cows with mastitis—A global systematic review |
| title_full | Prevalence and risk factors of Klebsiella spp. in milk samples from dairy cows with mastitis—A global systematic review |
| title_fullStr | Prevalence and risk factors of Klebsiella spp. in milk samples from dairy cows with mastitis—A global systematic review |
| title_full_unstemmed | Prevalence and risk factors of Klebsiella spp. in milk samples from dairy cows with mastitis—A global systematic review |
| title_short | Prevalence and risk factors of Klebsiella spp. in milk samples from dairy cows with mastitis—A global systematic review |
| title_sort | prevalence and risk factors of klebsiella spp in milk samples from dairy cows with mastitis a global systematic review |
| topic | meta-analysis bovine mastitis Klebsiella multidrug-resistance (MDR) prevalence |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2023.1143257/full |
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