Angiopoietin/Tie2 pathway mediates type 2 diabetes induced vascular damage after cerebral stroke

Angiopoietin/Tie2 pathway mediates type 2 diabetes induced vascular damage after cerebral stroke

We investigated the changes and the molecular mechanisms of cerebral vascular damage after stroke in type-2 diabetic (T2DM) mice. Adult male db/db T2DM and wild-type (WT) mice were subjected to transient middle cerebral artery occlusion (MCAo) and sacrificed 24 hours after MCAo. T2DM-mice exhibited...

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Bibliographic Details
Main Authors: Xu Cui, Michael Chopp, Alex Zacharek, Xinchun Ye, Cynthia Roberts, Jieli Chen
Format: Article
Language:English
Published: Elsevier 2011-07-01
Series:Neurobiology of Disease
Subjects:
Diabetes
Vascular damage
Angiopoietin
Stroke
Mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111001227

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