Brain Vitamin E Deficiency During Development Is Associated With Increased Glutamate Levels and Anxiety in Adult Mice
Vitamin E, the most important lipophilic radical scavenging antioxidant in vivo, has a pivotal role in brain. In an earlier study, we observed that adult mice with a defect in the gene encoding plasma phospholipid transfer protein (PLTP) display a moderate reduction in cerebral vitamin E levels, and...
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| Format: | Article |
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Frontiers Media S.A.
2018-12-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnbeh.2018.00310/full |
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| author | Catherine M. Desrumaux Catherine M. Desrumaux Catherine M. Desrumaux Catherine M. Desrumaux Marine Mansuy Marine Mansuy Marine Mansuy Marine Mansuy Stéphanie Lemaire Stéphanie Lemaire Stéphanie Lemaire Stéphanie Lemaire Justine Przybilski Justine Przybilski Justine Przybilski Justine Przybilski Naig Le Guern Naig Le Guern Naig Le Guern Laurent Givalois Laurent Givalois Laurent Givalois Laurent Givalois Laurent Lagrost Laurent Lagrost Laurent Lagrost |
| author_facet | Catherine M. Desrumaux Catherine M. Desrumaux Catherine M. Desrumaux Catherine M. Desrumaux Marine Mansuy Marine Mansuy Marine Mansuy Marine Mansuy Stéphanie Lemaire Stéphanie Lemaire Stéphanie Lemaire Stéphanie Lemaire Justine Przybilski Justine Przybilski Justine Przybilski Justine Przybilski Naig Le Guern Naig Le Guern Naig Le Guern Laurent Givalois Laurent Givalois Laurent Givalois Laurent Givalois Laurent Lagrost Laurent Lagrost Laurent Lagrost |
| author_sort | Catherine M. Desrumaux |
| collection | DOAJ |
| description | Vitamin E, the most important lipophilic radical scavenging antioxidant in vivo, has a pivotal role in brain. In an earlier study, we observed that adult mice with a defect in the gene encoding plasma phospholipid transfer protein (PLTP) display a moderate reduction in cerebral vitamin E levels, and exacerbated anxiety despite normal locomotion and memory functions. Here we sought to determine whether dietary vitamin E supplementation can modulate neurotransmitter levels and alleviate the increased anxiety phenotype of PLTP-deficient (PLTP−/−) mice. To address this question, a vitamin E-enriched diet was used, and two complementary approches were implemented: (i) “early supplementation”: neurotransmitter levels and anxiety were assessed in 6 months old PLTP−/− mice born from vitamin E-supplemented parents; and (ii) “late supplementation”: neurotransmitter levels and anxiety were assessed in 6 months old PLTP−/− mice fed a vitamin E-enriched diet from weaning. Our results show for the first time that an inadequate supply of vitamin E during development, due to moderate maternal vitamin E deficiency, is associated with reduced brain vitamin E levels at birth and irreversible alterations in brain glutamate levels. They also suggest this deficiency is associated with increased anxiety at adulthood. Thus, the present study leads to conclude on the importance of the micronutrient vitamin E during pregnancy. |
| first_indexed | 2024-04-14T06:25:42Z |
| format | Article |
| id | doaj.art-fb0ce249bb6e4cdebcde7c0a22a44df5 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-04-14T06:25:42Z |
| publishDate | 2018-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-fb0ce249bb6e4cdebcde7c0a22a44df52022-12-22T02:07:52ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532018-12-011210.3389/fnbeh.2018.00310422963Brain Vitamin E Deficiency During Development Is Associated With Increased Glutamate Levels and Anxiety in Adult MiceCatherine M. Desrumaux0Catherine M. Desrumaux1Catherine M. Desrumaux2Catherine M. Desrumaux3Marine Mansuy4Marine Mansuy5Marine Mansuy6Marine Mansuy7Stéphanie Lemaire8Stéphanie Lemaire9Stéphanie Lemaire10Stéphanie Lemaire11Justine Przybilski12Justine Przybilski13Justine Przybilski14Justine Przybilski15Naig Le Guern16Naig Le Guern17Naig Le Guern18Laurent Givalois19Laurent Givalois20Laurent Givalois21Laurent Givalois22Laurent Lagrost23Laurent Lagrost24Laurent Lagrost25INSERM, U1198, Team “Environmental Impacts in Alzheimer’s Disease and Related Disorders” (EiAlz), Montpellier, FranceFaculty of Sciences, Université Montpellier, Montpellier, FranceEPHE, Paris, FranceLipSTIC LabEx, Fondation de Coopération Scientifique Bourgogne-Franche Comté, Dijon, FranceINSERM, U1198, Team “Environmental Impacts in Alzheimer’s Disease and Related Disorders” (EiAlz), Montpellier, FranceFaculty of Sciences, Université Montpellier, Montpellier, FranceEPHE, Paris, FranceLipSTIC LabEx, Fondation de Coopération Scientifique Bourgogne-Franche Comté, Dijon, FranceLipSTIC LabEx, Fondation de Coopération Scientifique Bourgogne-Franche Comté, Dijon, FranceINSERM, LNC UMR1231, Dijon, FranceUniversity Bourgogne Franche-Comté, LNC UMR1231, Dijon, FranceHôpital du Bocage, Dijon, FranceINSERM, U1198, Team “Environmental Impacts in Alzheimer’s Disease and Related Disorders” (EiAlz), Montpellier, FranceFaculty of Sciences, Université Montpellier, Montpellier, FranceEPHE, Paris, FranceLipSTIC LabEx, Fondation de Coopération Scientifique Bourgogne-Franche Comté, Dijon, FranceLipSTIC LabEx, Fondation de Coopération Scientifique Bourgogne-Franche Comté, Dijon, FranceINSERM, LNC UMR1231, Dijon, FranceUniversity Bourgogne Franche-Comté, LNC UMR1231, Dijon, FranceINSERM, U1198, Team “Environmental Impacts in Alzheimer’s Disease and Related Disorders” (EiAlz), Montpellier, FranceFaculty of Sciences, Université Montpellier, Montpellier, FranceEPHE, Paris, FranceLipSTIC LabEx, Fondation de Coopération Scientifique Bourgogne-Franche Comté, Dijon, FranceLipSTIC LabEx, Fondation de Coopération Scientifique Bourgogne-Franche Comté, Dijon, FranceINSERM, LNC UMR1231, Dijon, FranceUniversity Bourgogne Franche-Comté, LNC UMR1231, Dijon, FranceVitamin E, the most important lipophilic radical scavenging antioxidant in vivo, has a pivotal role in brain. In an earlier study, we observed that adult mice with a defect in the gene encoding plasma phospholipid transfer protein (PLTP) display a moderate reduction in cerebral vitamin E levels, and exacerbated anxiety despite normal locomotion and memory functions. Here we sought to determine whether dietary vitamin E supplementation can modulate neurotransmitter levels and alleviate the increased anxiety phenotype of PLTP-deficient (PLTP−/−) mice. To address this question, a vitamin E-enriched diet was used, and two complementary approches were implemented: (i) “early supplementation”: neurotransmitter levels and anxiety were assessed in 6 months old PLTP−/− mice born from vitamin E-supplemented parents; and (ii) “late supplementation”: neurotransmitter levels and anxiety were assessed in 6 months old PLTP−/− mice fed a vitamin E-enriched diet from weaning. Our results show for the first time that an inadequate supply of vitamin E during development, due to moderate maternal vitamin E deficiency, is associated with reduced brain vitamin E levels at birth and irreversible alterations in brain glutamate levels. They also suggest this deficiency is associated with increased anxiety at adulthood. Thus, the present study leads to conclude on the importance of the micronutrient vitamin E during pregnancy.https://www.frontiersin.org/article/10.3389/fnbeh.2018.00310/fullvitamin Elipid transferdevelopmentbrainglutamate |
| spellingShingle | Catherine M. Desrumaux Catherine M. Desrumaux Catherine M. Desrumaux Catherine M. Desrumaux Marine Mansuy Marine Mansuy Marine Mansuy Marine Mansuy Stéphanie Lemaire Stéphanie Lemaire Stéphanie Lemaire Stéphanie Lemaire Justine Przybilski Justine Przybilski Justine Przybilski Justine Przybilski Naig Le Guern Naig Le Guern Naig Le Guern Laurent Givalois Laurent Givalois Laurent Givalois Laurent Givalois Laurent Lagrost Laurent Lagrost Laurent Lagrost Brain Vitamin E Deficiency During Development Is Associated With Increased Glutamate Levels and Anxiety in Adult Mice Frontiers in Behavioral Neuroscience vitamin E lipid transfer development brain glutamate |
| title | Brain Vitamin E Deficiency During Development Is Associated With Increased Glutamate Levels and Anxiety in Adult Mice |
| title_full | Brain Vitamin E Deficiency During Development Is Associated With Increased Glutamate Levels and Anxiety in Adult Mice |
| title_fullStr | Brain Vitamin E Deficiency During Development Is Associated With Increased Glutamate Levels and Anxiety in Adult Mice |
| title_full_unstemmed | Brain Vitamin E Deficiency During Development Is Associated With Increased Glutamate Levels and Anxiety in Adult Mice |
| title_short | Brain Vitamin E Deficiency During Development Is Associated With Increased Glutamate Levels and Anxiety in Adult Mice |
| title_sort | brain vitamin e deficiency during development is associated with increased glutamate levels and anxiety in adult mice |
| topic | vitamin E lipid transfer development brain glutamate |
| url | https://www.frontiersin.org/article/10.3389/fnbeh.2018.00310/full |
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