Comparison of risks of thromboembolism of drospirenone-containing and nondrospirenone -containing combined oral contraceptive use: A meta-analysis
This study aimed to estimate the risk of venous thromboembolism (VTE), arterial thromboembolism (ATE), and other side effects following the use of drospirenone (DRSP)-containing combined oral contraceptives (COCs). When compared with non-DRSP-containing COCs, DRSP-containing COCs decreased the risk...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health/LWW
2021-01-01
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| Series: | Reproductive and Developmental Medicine |
| Subjects: | |
| Online Access: | http://www.repdevmed.org/article.asp?issn=2096-2924;year=2021;volume=5;issue=3;spage=154;epage=160;aulast=Zhang |
| _version_ | 1818237844112539648 |
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| author | Wan-Lin Zhang Zhe Dong Jun-Yan Zhang Min-Zhi Lyu Wei Zhang Jian-Lei Huang Xin Yang |
| author_facet | Wan-Lin Zhang Zhe Dong Jun-Yan Zhang Min-Zhi Lyu Wei Zhang Jian-Lei Huang Xin Yang |
| author_sort | Wan-Lin Zhang |
| collection | DOAJ |
| description | This study aimed to estimate the risk of venous thromboembolism (VTE), arterial thromboembolism (ATE), and other side effects following the use of drospirenone (DRSP)-containing combined oral contraceptives (COCs). When compared with non-DRSP-containing COCs, DRSP-containing COCs decreased the risk of VTE by 15% in the overall study population, although this was not statistically significant (adjusted hazard ratio/risk ratio [95% confidence interval] 0.85 [0.69, 1.04]). DRSP-containing COCs also showed significant benefits in terms of ATE risk. The body mass index of the subjects significantly decreased by 0.64 kg/m2 after taking the DRSP-containing COCs for 6 months. We concluded that DRSP-containing COCs were safe for use and could be broadly recommended. |
| first_indexed | 2024-12-12T12:32:13Z |
| format | Article |
| id | doaj.art-fb0d9b4e6a214d16b95021279d6a00aa |
| institution | Directory Open Access Journal |
| issn | 2096-2924 2589-8728 |
| language | English |
| last_indexed | 2024-12-12T12:32:13Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Reproductive and Developmental Medicine |
| spelling | doaj.art-fb0d9b4e6a214d16b95021279d6a00aa2022-12-22T00:24:25ZengWolters Kluwer Health/LWWReproductive and Developmental Medicine2096-29242589-87282021-01-015315416010.4103/2096-2924.324822Comparison of risks of thromboembolism of drospirenone-containing and nondrospirenone -containing combined oral contraceptive use: A meta-analysisWan-Lin ZhangZhe DongJun-Yan ZhangMin-Zhi LyuWei ZhangJian-Lei HuangXin YangThis study aimed to estimate the risk of venous thromboembolism (VTE), arterial thromboembolism (ATE), and other side effects following the use of drospirenone (DRSP)-containing combined oral contraceptives (COCs). When compared with non-DRSP-containing COCs, DRSP-containing COCs decreased the risk of VTE by 15% in the overall study population, although this was not statistically significant (adjusted hazard ratio/risk ratio [95% confidence interval] 0.85 [0.69, 1.04]). DRSP-containing COCs also showed significant benefits in terms of ATE risk. The body mass index of the subjects significantly decreased by 0.64 kg/m2 after taking the DRSP-containing COCs for 6 months. We concluded that DRSP-containing COCs were safe for use and could be broadly recommended.http://www.repdevmed.org/article.asp?issn=2096-2924;year=2021;volume=5;issue=3;spage=154;epage=160;aulast=Zhangarterial thromboembolism; combined oral contraceptives; drospirenone; venous thromboembolism |
| spellingShingle | Wan-Lin Zhang Zhe Dong Jun-Yan Zhang Min-Zhi Lyu Wei Zhang Jian-Lei Huang Xin Yang Comparison of risks of thromboembolism of drospirenone-containing and nondrospirenone -containing combined oral contraceptive use: A meta-analysis Reproductive and Developmental Medicine arterial thromboembolism; combined oral contraceptives; drospirenone; venous thromboembolism |
| title | Comparison of risks of thromboembolism of drospirenone-containing and nondrospirenone -containing combined oral contraceptive use: A meta-analysis |
| title_full | Comparison of risks of thromboembolism of drospirenone-containing and nondrospirenone -containing combined oral contraceptive use: A meta-analysis |
| title_fullStr | Comparison of risks of thromboembolism of drospirenone-containing and nondrospirenone -containing combined oral contraceptive use: A meta-analysis |
| title_full_unstemmed | Comparison of risks of thromboembolism of drospirenone-containing and nondrospirenone -containing combined oral contraceptive use: A meta-analysis |
| title_short | Comparison of risks of thromboembolism of drospirenone-containing and nondrospirenone -containing combined oral contraceptive use: A meta-analysis |
| title_sort | comparison of risks of thromboembolism of drospirenone containing and nondrospirenone containing combined oral contraceptive use a meta analysis |
| topic | arterial thromboembolism; combined oral contraceptives; drospirenone; venous thromboembolism |
| url | http://www.repdevmed.org/article.asp?issn=2096-2924;year=2021;volume=5;issue=3;spage=154;epage=160;aulast=Zhang |
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