High salt diet ameliorates functional, electrophysiological and histological characteristics of murine spontaneous autoimmune polyneuropathy
Background: It was previously reported that high salt dietary conditions can drive autoimmunity and worsen severity and symptoms of autoimmune diseases. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a common autoimmune condition of the peripheral nervous system which leads to p...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-04-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996118307484 |
| _version_ | 1818646017339293696 |
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| author | Petra Huehnchen Wolfgang Boehmerle Matthias Endres |
| author_facet | Petra Huehnchen Wolfgang Boehmerle Matthias Endres |
| author_sort | Petra Huehnchen |
| collection | DOAJ |
| description | Background: It was previously reported that high salt dietary conditions can drive autoimmunity and worsen severity and symptoms of autoimmune diseases. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a common autoimmune condition of the peripheral nervous system which leads to progressive paralysis and sensory deficits due to a demyelination and secondary axonal loss of peripheral nerves. We used a previously described model with a knockout of CD86 in non-obese diabetic mice (CD86−/− NOD), which results in the spontaneous development of an autoimmune peripheral neuropathy similar to CIDP and investigated the influence of a high salt diet on functional impairment, electrophysiological parameters, demyelination and neuroinflammation in these mice. Methods: At seven weeks of age, asymptomatic female CD86−/− NOD mice were randomly assigned to a normal or high salt diet containing 4% sodium chloride in food and 1% in water. The diet was continued for a total of 30 weeks. Results: Mice on the high salt diet showed a delayed onset of clinical symptoms and an ameliorated disease course with a reduced decline of locomotor function. Furthermore, electrophysiological parameters of neuropathy and demyelination were attenuated in mice on the high salt diet, which was confirmed with histological analysis. Additionally, we observed a reduced immune cell infiltration of sciatic nerves in mice which had received the high salt diet. Conclusions: We demonstrate beneficial effects of high salt diet regarding disease progression, functional, electrophysiological and histological parameters in a transgenic mouse model of spontaneous autoimmune neuropathy. |
| first_indexed | 2024-12-17T00:39:57Z |
| format | Article |
| id | doaj.art-fb11cabca93140a0a671722f46525688 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-17T00:39:57Z |
| publishDate | 2019-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-fb11cabca93140a0a671722f465256882022-12-21T22:10:03ZengElsevierNeurobiology of Disease1095-953X2019-04-01124240247High salt diet ameliorates functional, electrophysiological and histological characteristics of murine spontaneous autoimmune polyneuropathyPetra Huehnchen0Wolfgang Boehmerle1Matthias Endres2Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany; Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Cluster of Excellence NeuroCure, Berlin, Germany; Berlin Institute of Health, 10178 Berlin, Germany; Corresponding author at: Charité Universitätsmedizin Berlin, Klinik für Neurologie, Charitéplatz 1, Berlin 10117, Germany.Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany; Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Cluster of Excellence NeuroCure, Berlin, Germany; Berlin Institute of Health, 10178 Berlin, GermanyCharité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany; Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Cluster of Excellence NeuroCure, Berlin, Germany; Berlin Institute of Health, 10178 Berlin, Germany; Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Center for Stroke Resarch Berlin, Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany; DZHK (German Center for Cardiovascular Research), partner site Berlin, Berlin, GermanyBackground: It was previously reported that high salt dietary conditions can drive autoimmunity and worsen severity and symptoms of autoimmune diseases. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a common autoimmune condition of the peripheral nervous system which leads to progressive paralysis and sensory deficits due to a demyelination and secondary axonal loss of peripheral nerves. We used a previously described model with a knockout of CD86 in non-obese diabetic mice (CD86−/− NOD), which results in the spontaneous development of an autoimmune peripheral neuropathy similar to CIDP and investigated the influence of a high salt diet on functional impairment, electrophysiological parameters, demyelination and neuroinflammation in these mice. Methods: At seven weeks of age, asymptomatic female CD86−/− NOD mice were randomly assigned to a normal or high salt diet containing 4% sodium chloride in food and 1% in water. The diet was continued for a total of 30 weeks. Results: Mice on the high salt diet showed a delayed onset of clinical symptoms and an ameliorated disease course with a reduced decline of locomotor function. Furthermore, electrophysiological parameters of neuropathy and demyelination were attenuated in mice on the high salt diet, which was confirmed with histological analysis. Additionally, we observed a reduced immune cell infiltration of sciatic nerves in mice which had received the high salt diet. Conclusions: We demonstrate beneficial effects of high salt diet regarding disease progression, functional, electrophysiological and histological parameters in a transgenic mouse model of spontaneous autoimmune neuropathy.http://www.sciencedirect.com/science/article/pii/S0969996118307484Chronic inflammatory demyelinating polyradiculoneuropathyAutoimmune neuropathyHigh salt dietNeuroinflammationDemyelination |
| spellingShingle | Petra Huehnchen Wolfgang Boehmerle Matthias Endres High salt diet ameliorates functional, electrophysiological and histological characteristics of murine spontaneous autoimmune polyneuropathy Neurobiology of Disease Chronic inflammatory demyelinating polyradiculoneuropathy Autoimmune neuropathy High salt diet Neuroinflammation Demyelination |
| title | High salt diet ameliorates functional, electrophysiological and histological characteristics of murine spontaneous autoimmune polyneuropathy |
| title_full | High salt diet ameliorates functional, electrophysiological and histological characteristics of murine spontaneous autoimmune polyneuropathy |
| title_fullStr | High salt diet ameliorates functional, electrophysiological and histological characteristics of murine spontaneous autoimmune polyneuropathy |
| title_full_unstemmed | High salt diet ameliorates functional, electrophysiological and histological characteristics of murine spontaneous autoimmune polyneuropathy |
| title_short | High salt diet ameliorates functional, electrophysiological and histological characteristics of murine spontaneous autoimmune polyneuropathy |
| title_sort | high salt diet ameliorates functional electrophysiological and histological characteristics of murine spontaneous autoimmune polyneuropathy |
| topic | Chronic inflammatory demyelinating polyradiculoneuropathy Autoimmune neuropathy High salt diet Neuroinflammation Demyelination |
| url | http://www.sciencedirect.com/science/article/pii/S0969996118307484 |
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