Association of complement components with the risk and severity of NAFLD: A systematic review and meta-analysis
BackgroundIt is generally believed that complement system is strongly associated with the risk of nonalcoholic fatty liver disease (NAFLD). However, complement system contains a variety of complement components, and the relationship between complement components and the risk and severity of NAFLD is...
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1054159/full |
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| author | Jianbo Zhao Jianbo Zhao Jianbo Zhao Jianbo Zhao Jianbo Zhao Jianbo Zhao Yafei Wu Yafei Wu Yafei Wu Yafei Wu Yafei Wu Peng Lu Peng Lu Peng Lu Peng Lu Peng Lu Xiaoqin Wu Junming Han Junming Han Junming Han Junming Han Junming Han Yingzhou Shi Yingzhou Shi Yingzhou Shi Yingzhou Shi Yingzhou Shi Yue Liu Yue Liu Yue Liu Yue Liu Yue Liu Yiping Cheng Yiping Cheng Yiping Cheng Yiping Cheng Yiping Cheng Ling Gao Ling Gao Ling Gao Ling Gao Ling Gao Jiajun Zhao Jiajun Zhao Jiajun Zhao Jiajun Zhao Jiajun Zhao Jiajun Zhao Zhen Wang Zhen Wang Zhen Wang Zhen Wang Zhen Wang Xiude Fan Xiude Fan Xiude Fan Xiude Fan Xiude Fan |
| author_facet | Jianbo Zhao Jianbo Zhao Jianbo Zhao Jianbo Zhao Jianbo Zhao Jianbo Zhao Yafei Wu Yafei Wu Yafei Wu Yafei Wu Yafei Wu Peng Lu Peng Lu Peng Lu Peng Lu Peng Lu Xiaoqin Wu Junming Han Junming Han Junming Han Junming Han Junming Han Yingzhou Shi Yingzhou Shi Yingzhou Shi Yingzhou Shi Yingzhou Shi Yue Liu Yue Liu Yue Liu Yue Liu Yue Liu Yiping Cheng Yiping Cheng Yiping Cheng Yiping Cheng Yiping Cheng Ling Gao Ling Gao Ling Gao Ling Gao Ling Gao Jiajun Zhao Jiajun Zhao Jiajun Zhao Jiajun Zhao Jiajun Zhao Jiajun Zhao Zhen Wang Zhen Wang Zhen Wang Zhen Wang Zhen Wang Xiude Fan Xiude Fan Xiude Fan Xiude Fan Xiude Fan |
| author_sort | Jianbo Zhao |
| collection | DOAJ |
| description | BackgroundIt is generally believed that complement system is strongly associated with the risk of nonalcoholic fatty liver disease (NAFLD). However, complement system contains a variety of complement components, and the relationship between complement components and the risk and severity of NAFLD is inconsistent. The aim of this meta-analysis was to evaluate the association of complement components with the risk and severity of NAFLD.MethodsWe searched PubMed, Embase, Cochrane Library, Google Scholar, Scopus, and ZhiWang Chinese databases from inception to May 2022 for observational studies reporting the risk of NAFLD with complement components. Random-effects meta-analysis was used to obtain pooled estimates of the effect due to heterogeneity.ResultsWe identified 18 studies with a total of 18560 included subjects. According to recent studies, levels of complement component 3 (C3) (mean difference (MD): 0.43, 95% confidence interval (CI) 0.26-0.60), complement component 4 (C4) (MD: 0.04, 95% CI 0.02-0.07), complement component 5(C5) (MD: 34.03, 95% CI 30.80-37.27), complement factor B (CFB) (MD: 0.22, 95% CI 0.13-0.31) and acylation stimulating protein (ASP) (standard mean difference (SMD): 5.17, 95% CI 2.57-7.77) in patients with NAFLD were significantly higher than those in the control group. However, no statistical significance was obtained in complement factor D (CFD) levels between NAFLD and non-NAFLD (MD=156.51, 95% CI -59.38-372.40). Moreover, the levels of C3, C5, CFB, and ASP in patients with moderate and severe NAFLD were significantly higher than those in patients with mild NAFLD. Except for C4 and CFD, the included studies did not explore the changes in the severity of NAFLD according to the concentration of C4 and CFD.ConclusionsThis meta-analysis demonstrates that an increase in complement components including C3, C5, CFB, and ASP is associated with an increased risk and severity of NAFLD, indicating that they may be good biomarkers and targets for the diagnosis and treatment of NAFLD.Systematic review registrationPROSPERO [https://www.crd.york.ac.uk/PROSPERO/], identifier CRD42022348650. |
| first_indexed | 2024-04-12T03:27:53Z |
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| id | doaj.art-fb129abafabc429b8f8f91a72e29c497 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T03:27:53Z |
| publishDate | 2022-12-01 |
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| series | Frontiers in Immunology |
| spelling | doaj.art-fb129abafabc429b8f8f91a72e29c4972022-12-22T03:49:39ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-12-011310.3389/fimmu.2022.10541591054159Association of complement components with the risk and severity of NAFLD: A systematic review and meta-analysisJianbo Zhao0Jianbo Zhao1Jianbo Zhao2Jianbo Zhao3Jianbo Zhao4Jianbo Zhao5Yafei Wu6Yafei Wu7Yafei Wu8Yafei Wu9Yafei Wu10Peng Lu11Peng Lu12Peng Lu13Peng Lu14Peng Lu15Xiaoqin Wu16Junming Han17Junming Han18Junming Han19Junming Han20Junming Han21Yingzhou Shi22Yingzhou Shi23Yingzhou Shi24Yingzhou Shi25Yingzhou Shi26Yue Liu27Yue Liu28Yue Liu29Yue Liu30Yue Liu31Yiping Cheng32Yiping Cheng33Yiping Cheng34Yiping Cheng35Yiping Cheng36Ling Gao37Ling Gao38Ling Gao39Ling Gao40Ling Gao41Jiajun Zhao42Jiajun Zhao43Jiajun Zhao44Jiajun Zhao45Jiajun Zhao46Jiajun Zhao47Zhen Wang48Zhen Wang49Zhen Wang50Zhen Wang51Zhen Wang52Xiude Fan53Xiude Fan54Xiude Fan55Xiude Fan56Xiude Fan57Clinical Medical College, Ningxia Medical University, Yinchuan, Ningxia, ChinaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, ChinaShandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, ChinaShandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaShandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, ChinaShandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, ChinaShandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaShandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, ChinaShandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, ChinaShandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaShandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaDepartment of Inflammation and Immunity, Cleveland Clinic, OH, Cleveland, United StatesDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, ChinaShandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, ChinaShandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaShandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, ChinaShandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, ChinaShandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaShandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, ChinaShandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, ChinaShandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaShandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, ChinaShandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, ChinaShandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaShandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, ChinaShandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, ChinaShandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaShandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaClinical Medical College, Ningxia Medical University, Yinchuan, Ningxia, ChinaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, ChinaShandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, ChinaShandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaShandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, ChinaShandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, ChinaShandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaShandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaDepartment of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, ChinaShandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong, ChinaShandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaShandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaBackgroundIt is generally believed that complement system is strongly associated with the risk of nonalcoholic fatty liver disease (NAFLD). However, complement system contains a variety of complement components, and the relationship between complement components and the risk and severity of NAFLD is inconsistent. The aim of this meta-analysis was to evaluate the association of complement components with the risk and severity of NAFLD.MethodsWe searched PubMed, Embase, Cochrane Library, Google Scholar, Scopus, and ZhiWang Chinese databases from inception to May 2022 for observational studies reporting the risk of NAFLD with complement components. Random-effects meta-analysis was used to obtain pooled estimates of the effect due to heterogeneity.ResultsWe identified 18 studies with a total of 18560 included subjects. According to recent studies, levels of complement component 3 (C3) (mean difference (MD): 0.43, 95% confidence interval (CI) 0.26-0.60), complement component 4 (C4) (MD: 0.04, 95% CI 0.02-0.07), complement component 5(C5) (MD: 34.03, 95% CI 30.80-37.27), complement factor B (CFB) (MD: 0.22, 95% CI 0.13-0.31) and acylation stimulating protein (ASP) (standard mean difference (SMD): 5.17, 95% CI 2.57-7.77) in patients with NAFLD were significantly higher than those in the control group. However, no statistical significance was obtained in complement factor D (CFD) levels between NAFLD and non-NAFLD (MD=156.51, 95% CI -59.38-372.40). Moreover, the levels of C3, C5, CFB, and ASP in patients with moderate and severe NAFLD were significantly higher than those in patients with mild NAFLD. Except for C4 and CFD, the included studies did not explore the changes in the severity of NAFLD according to the concentration of C4 and CFD.ConclusionsThis meta-analysis demonstrates that an increase in complement components including C3, C5, CFB, and ASP is associated with an increased risk and severity of NAFLD, indicating that they may be good biomarkers and targets for the diagnosis and treatment of NAFLD.Systematic review registrationPROSPERO [https://www.crd.york.ac.uk/PROSPERO/], identifier CRD42022348650.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1054159/fullnonalcoholic fatty liver diseasecomplement componentsdisease progressiondisease severitybiomarkermeta-analysis |
| spellingShingle | Jianbo Zhao Jianbo Zhao Jianbo Zhao Jianbo Zhao Jianbo Zhao Jianbo Zhao Yafei Wu Yafei Wu Yafei Wu Yafei Wu Yafei Wu Peng Lu Peng Lu Peng Lu Peng Lu Peng Lu Xiaoqin Wu Junming Han Junming Han Junming Han Junming Han Junming Han Yingzhou Shi Yingzhou Shi Yingzhou Shi Yingzhou Shi Yingzhou Shi Yue Liu Yue Liu Yue Liu Yue Liu Yue Liu Yiping Cheng Yiping Cheng Yiping Cheng Yiping Cheng Yiping Cheng Ling Gao Ling Gao Ling Gao Ling Gao Ling Gao Jiajun Zhao Jiajun Zhao Jiajun Zhao Jiajun Zhao Jiajun Zhao Jiajun Zhao Zhen Wang Zhen Wang Zhen Wang Zhen Wang Zhen Wang Xiude Fan Xiude Fan Xiude Fan Xiude Fan Xiude Fan Association of complement components with the risk and severity of NAFLD: A systematic review and meta-analysis Frontiers in Immunology nonalcoholic fatty liver disease complement components disease progression disease severity biomarker meta-analysis |
| title | Association of complement components with the risk and severity of NAFLD: A systematic review and meta-analysis |
| title_full | Association of complement components with the risk and severity of NAFLD: A systematic review and meta-analysis |
| title_fullStr | Association of complement components with the risk and severity of NAFLD: A systematic review and meta-analysis |
| title_full_unstemmed | Association of complement components with the risk and severity of NAFLD: A systematic review and meta-analysis |
| title_short | Association of complement components with the risk and severity of NAFLD: A systematic review and meta-analysis |
| title_sort | association of complement components with the risk and severity of nafld a systematic review and meta analysis |
| topic | nonalcoholic fatty liver disease complement components disease progression disease severity biomarker meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1054159/full |
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