New index using triglyceride glucose-body mass index for predicting mortality in patients with antineutrophil cytoplasmic antibody-associated vasculitis
BackgroundThis study aimed to investigate whether triglyceride glucose-body mass index (TyG-BMI) and a new index using TyG-BMI (NITGB) could predict all-cause mortality in non-obese patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).MethodsThe medical records of 78...
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1168016/full |
| _version_ | 1797823673848037376 |
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| author | Pil Gyu Park Jung Yoon Pyo Sung Soo Ahn Jason Jungsik Song Jason Jungsik Song Yong-Beom Park Yong-Beom Park Ji Hye Huh Sang-Won Lee Sang-Won Lee |
| author_facet | Pil Gyu Park Jung Yoon Pyo Sung Soo Ahn Jason Jungsik Song Jason Jungsik Song Yong-Beom Park Yong-Beom Park Ji Hye Huh Sang-Won Lee Sang-Won Lee |
| author_sort | Pil Gyu Park |
| collection | DOAJ |
| description | BackgroundThis study aimed to investigate whether triglyceride glucose-body mass index (TyG-BMI) and a new index using TyG-BMI (NITGB) could predict all-cause mortality in non-obese patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).MethodsThe medical records of 78 non-obese AAV patients (BMI < 23.0 kg/m2 for Asians) were retrospectively reviewed. TyG-BMI was calculated by the equation: Ln (triglyceride × fasting glucose/2) × BMI. To develop NITGB, we assigned a weight of a number close to an 0.1 decimal integer to each variable according to the slopes for independent variables with P-value < 0.1 in the multivariable Cox analysis.ResultsThe median age was 54.3 years and five patients died. When non-obese AAV patients were divided into two groups based on TyG-BMI ≥ 187.74, those with TyG-BMI ≥ 187.74 exhibited a significantly higher risk for all-cause mortality than those without (RR 9.450). Since age (HR 1.324), Birmingham vasculitis activity score (BVAS; HR 1.212), and TyG-BMI ≥ 187.74 (HR 12.168) were independently associated with all-cause mortality, NITGB was developed as follows: age + 0.2 × BVAS + 2.5 × TyG-BMI ≥ 187.74. When non-obese AAV patients were divided into two groups based on NITGB ≥ 27.36, those with NITGB ≥ 27.36 showed a significantly higher risk for all-cause mortality than those without (RR 284.000). Both non-obese AAV patients with TyG-BMI ≥ 187.74 and those with NITGB ≥ 27.36 exhibited significantly higher cumulative rates of all-cause mortality than those without.ConclusionNITGB along with TyG-BMI could predict all-cause mortality in non-obese AAV patients. |
| first_indexed | 2024-03-13T10:27:27Z |
| format | Article |
| id | doaj.art-fb1396d25cf14db9b59e130b8f370b2d |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-13T10:27:27Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj.art-fb1396d25cf14db9b59e130b8f370b2d2023-05-19T05:57:36ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-05-011010.3389/fmed.2023.11680161168016New index using triglyceride glucose-body mass index for predicting mortality in patients with antineutrophil cytoplasmic antibody-associated vasculitisPil Gyu Park0Jung Yoon Pyo1Sung Soo Ahn2Jason Jungsik Song3Jason Jungsik Song4Yong-Beom Park5Yong-Beom Park6Ji Hye Huh7Sang-Won Lee8Sang-Won Lee9Division of Rheumatology, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Republic of KoreaDivision of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of KoreaDivision of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of KoreaDivision of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of KoreaInstitute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of KoreaDivision of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of KoreaInstitute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of KoreaDivision of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of KoreaInstitute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of KoreaBackgroundThis study aimed to investigate whether triglyceride glucose-body mass index (TyG-BMI) and a new index using TyG-BMI (NITGB) could predict all-cause mortality in non-obese patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).MethodsThe medical records of 78 non-obese AAV patients (BMI < 23.0 kg/m2 for Asians) were retrospectively reviewed. TyG-BMI was calculated by the equation: Ln (triglyceride × fasting glucose/2) × BMI. To develop NITGB, we assigned a weight of a number close to an 0.1 decimal integer to each variable according to the slopes for independent variables with P-value < 0.1 in the multivariable Cox analysis.ResultsThe median age was 54.3 years and five patients died. When non-obese AAV patients were divided into two groups based on TyG-BMI ≥ 187.74, those with TyG-BMI ≥ 187.74 exhibited a significantly higher risk for all-cause mortality than those without (RR 9.450). Since age (HR 1.324), Birmingham vasculitis activity score (BVAS; HR 1.212), and TyG-BMI ≥ 187.74 (HR 12.168) were independently associated with all-cause mortality, NITGB was developed as follows: age + 0.2 × BVAS + 2.5 × TyG-BMI ≥ 187.74. When non-obese AAV patients were divided into two groups based on NITGB ≥ 27.36, those with NITGB ≥ 27.36 showed a significantly higher risk for all-cause mortality than those without (RR 284.000). Both non-obese AAV patients with TyG-BMI ≥ 187.74 and those with NITGB ≥ 27.36 exhibited significantly higher cumulative rates of all-cause mortality than those without.ConclusionNITGB along with TyG-BMI could predict all-cause mortality in non-obese AAV patients.https://www.frontiersin.org/articles/10.3389/fmed.2023.1168016/fullantineutrophil cytoplasmic antibody-associated vasculitismortalitypredictindexTyG-BMI |
| spellingShingle | Pil Gyu Park Jung Yoon Pyo Sung Soo Ahn Jason Jungsik Song Jason Jungsik Song Yong-Beom Park Yong-Beom Park Ji Hye Huh Sang-Won Lee Sang-Won Lee New index using triglyceride glucose-body mass index for predicting mortality in patients with antineutrophil cytoplasmic antibody-associated vasculitis Frontiers in Medicine antineutrophil cytoplasmic antibody-associated vasculitis mortality predict index TyG-BMI |
| title | New index using triglyceride glucose-body mass index for predicting mortality in patients with antineutrophil cytoplasmic antibody-associated vasculitis |
| title_full | New index using triglyceride glucose-body mass index for predicting mortality in patients with antineutrophil cytoplasmic antibody-associated vasculitis |
| title_fullStr | New index using triglyceride glucose-body mass index for predicting mortality in patients with antineutrophil cytoplasmic antibody-associated vasculitis |
| title_full_unstemmed | New index using triglyceride glucose-body mass index for predicting mortality in patients with antineutrophil cytoplasmic antibody-associated vasculitis |
| title_short | New index using triglyceride glucose-body mass index for predicting mortality in patients with antineutrophil cytoplasmic antibody-associated vasculitis |
| title_sort | new index using triglyceride glucose body mass index for predicting mortality in patients with antineutrophil cytoplasmic antibody associated vasculitis |
| topic | antineutrophil cytoplasmic antibody-associated vasculitis mortality predict index TyG-BMI |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1168016/full |
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