Impact of Assisted Reproduction Techniques on Adverse Maternal Outcomes and on the Rate of Hospitalization in Maternal Intensive Care
<i>Background and Objective:</i> The aim of this retrospective cohort study is to evaluate the impact of assisted reproductive treatment (ART) on adverse maternal outcomes and the rate of hospitalization in maternal intensive care (MIC) in a tertiary university center in Liege, Belgium....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/11/2030 |
| _version_ | 1797458483027640320 |
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| author | Julie Collée Laure Noel Laurence Seidel Frédéric Chantraine Michelle Nisolle Laurie Henry |
| author_facet | Julie Collée Laure Noel Laurence Seidel Frédéric Chantraine Michelle Nisolle Laurie Henry |
| author_sort | Julie Collée |
| collection | DOAJ |
| description | <i>Background and Objective:</i> The aim of this retrospective cohort study is to evaluate the impact of assisted reproductive treatment (ART) on adverse maternal outcomes and the rate of hospitalization in maternal intensive care (MIC) in a tertiary university center in Liege, Belgium. <i>Materials and Methods:</i> This is a retrospective cohort study comparing two groups, 6557 patients who achieved pregnancy spontaneously and 330 patients who achieved pregnancy after ART, between January 2020 and December 2022. These patients were followed in the academic obstetrics department of Citadelle Hospital, Liège. The database of the ART center was compared with the database of the delivery unit to determine the cohort of patients who conceived after ART. Adverse maternal outcomes and MIC hospitalization rates were compared with between spontaneous pregnancies and ART groups. ART groups were also compared with each other. <i>Results:</i> The rate of hospitalization in maternal intensive care for patients who achieved pregnancy spontaneously was 12.1%, compared to 17.3% after ART. Comparing the rate of pre-eclampsia, 3.5% of spontaneous pregnancies were complicated by pre-eclampsia, while after ART, 10.9% of patients developed this complication during pregnancy. This rate was higher after IVF (12%) compared to intrauterine insemination and particularly after frozen embryo transfer (FET) in artificial cycle (17.9%). The birthweight of newborns after ART was also analyzed. A significant difference was obtained when comparing fresh embryo transfer with FET. <i>Conclusions:</i> Our study confirmed that FET in artificial cycle is a risk factor for pre-eclampsia and that fresh embryo transfer is associated with a higher rate of newborns with a lower percentile of birthweight. Our data showed that the rate of MIC hospitalization was significantly higher after ART but did not differ between groups. |
| first_indexed | 2024-03-09T16:37:46Z |
| format | Article |
| id | doaj.art-fb143ad9de124517b7fc42d9056cdf49 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T16:37:46Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-fb143ad9de124517b7fc42d9056cdf492023-11-24T14:55:06ZengMDPI AGMedicina1010-660X1648-91442023-11-015911203010.3390/medicina59112030Impact of Assisted Reproduction Techniques on Adverse Maternal Outcomes and on the Rate of Hospitalization in Maternal Intensive CareJulie Collée0Laure Noel1Laurence Seidel2Frédéric Chantraine3Michelle Nisolle4Laurie Henry5Obstetrics and Gynecology Department, Centre Hospitalier Universitaire de Liège, Citadelle Hospital, Boulevard du 12ème de Ligne 1, 4000 Liege, BelgiumObstetrics and Gynecology Department, Centre Hospitalier Universitaire de Liège, Citadelle Hospital, Boulevard du 12ème de Ligne 1, 4000 Liege, BelgiumDepartment of Statistical Analysis, University of Liège (ULiège), 4000 Liege, BelgiumObstetrics and Gynecology Department, Centre Hospitalier Universitaire de Liège, Citadelle Hospital, Boulevard du 12ème de Ligne 1, 4000 Liege, BelgiumObstetrics and Gynecology Department, Centre Hospitalier Universitaire de Liège, Citadelle Hospital, Boulevard du 12ème de Ligne 1, 4000 Liege, BelgiumObstetrics and Gynecology Department, Centre Hospitalier Universitaire de Liège, Citadelle Hospital, Boulevard du 12ème de Ligne 1, 4000 Liege, Belgium<i>Background and Objective:</i> The aim of this retrospective cohort study is to evaluate the impact of assisted reproductive treatment (ART) on adverse maternal outcomes and the rate of hospitalization in maternal intensive care (MIC) in a tertiary university center in Liege, Belgium. <i>Materials and Methods:</i> This is a retrospective cohort study comparing two groups, 6557 patients who achieved pregnancy spontaneously and 330 patients who achieved pregnancy after ART, between January 2020 and December 2022. These patients were followed in the academic obstetrics department of Citadelle Hospital, Liège. The database of the ART center was compared with the database of the delivery unit to determine the cohort of patients who conceived after ART. Adverse maternal outcomes and MIC hospitalization rates were compared with between spontaneous pregnancies and ART groups. ART groups were also compared with each other. <i>Results:</i> The rate of hospitalization in maternal intensive care for patients who achieved pregnancy spontaneously was 12.1%, compared to 17.3% after ART. Comparing the rate of pre-eclampsia, 3.5% of spontaneous pregnancies were complicated by pre-eclampsia, while after ART, 10.9% of patients developed this complication during pregnancy. This rate was higher after IVF (12%) compared to intrauterine insemination and particularly after frozen embryo transfer (FET) in artificial cycle (17.9%). The birthweight of newborns after ART was also analyzed. A significant difference was obtained when comparing fresh embryo transfer with FET. <i>Conclusions:</i> Our study confirmed that FET in artificial cycle is a risk factor for pre-eclampsia and that fresh embryo transfer is associated with a higher rate of newborns with a lower percentile of birthweight. Our data showed that the rate of MIC hospitalization was significantly higher after ART but did not differ between groups.https://www.mdpi.com/1648-9144/59/11/2030assisted reproductive treatmentobstetrical complicationsmaternal intensive care unit |
| spellingShingle | Julie Collée Laure Noel Laurence Seidel Frédéric Chantraine Michelle Nisolle Laurie Henry Impact of Assisted Reproduction Techniques on Adverse Maternal Outcomes and on the Rate of Hospitalization in Maternal Intensive Care Medicina assisted reproductive treatment obstetrical complications maternal intensive care unit |
| title | Impact of Assisted Reproduction Techniques on Adverse Maternal Outcomes and on the Rate of Hospitalization in Maternal Intensive Care |
| title_full | Impact of Assisted Reproduction Techniques on Adverse Maternal Outcomes and on the Rate of Hospitalization in Maternal Intensive Care |
| title_fullStr | Impact of Assisted Reproduction Techniques on Adverse Maternal Outcomes and on the Rate of Hospitalization in Maternal Intensive Care |
| title_full_unstemmed | Impact of Assisted Reproduction Techniques on Adverse Maternal Outcomes and on the Rate of Hospitalization in Maternal Intensive Care |
| title_short | Impact of Assisted Reproduction Techniques on Adverse Maternal Outcomes and on the Rate of Hospitalization in Maternal Intensive Care |
| title_sort | impact of assisted reproduction techniques on adverse maternal outcomes and on the rate of hospitalization in maternal intensive care |
| topic | assisted reproductive treatment obstetrical complications maternal intensive care unit |
| url | https://www.mdpi.com/1648-9144/59/11/2030 |
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