Evaluation of Demographic, Clinical Characteristics and Side Effects in Multiple Sclerosis Patients Vaccinated Against SARS-CoV-2 Virus
Objective: Our primary objective in our study was to review the side effect of MS patients vaccinated against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) virus from Istanbul University, Istanbul Faculty of Medicine, Multiple Sclerosis and Myelin Diseases Outpatient Clinic. The secon...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2023-06-01
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| Series: | Türk Nöroloji Dergisi |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjn&un=TJN-97493 |
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| author | Özgü Kizek Gizem Yağmur Yalçın Tuncay Gündüz Murat Kürtüncü Mefküre Eraksoy |
| author_facet | Özgü Kizek Gizem Yağmur Yalçın Tuncay Gündüz Murat Kürtüncü Mefküre Eraksoy |
| author_sort | Özgü Kizek |
| collection | DOAJ |
| description | Objective: Our primary objective in our study was to review the side effect of MS patients vaccinated against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) virus from Istanbul University, Istanbul Faculty of Medicine, Multiple Sclerosis and Myelin Diseases Outpatient Clinic. The secondary objective of our research was to evaluate the demographic, clinical characteristics and disease-modifying therapies of patients who have been infected with coronavirus disease-2019 (COVID-19) and who have been vaccinated against the SARS-CoV-2 virus. Materials and Methods: A questionnaire was sent via text message or e-mail to patients who were followed up at the Multiple Sclerosis and Myelin Diseases Outpatient Clinic of the Department of Neurology of the Istanbul University, Istanbul Faculty of Medicine. The eligibility criteria were not being in the period of an attack and being volunteered to participate in the study. A questionnaire consisting of a total of 21 questions was answered by the patients and the results of 160 patients were evaluated statistically. Results: One hundred and seven of the 160 patients were women (67%), and 53 (33%) men. The mean age of the patients was 38 +- 10.9 years. As a majority of the patients, 128 of the patients (80%) were followed up with a diagnosis of relapsing remmitting multiple sclerosis (MS). The rate of COVID-19 infection among the patients was 17% (n = 27). 67.5% (n = 108) of the patients preferred the inactive SARS-CoV-2 vaccine, while 31.8% (n = 51) preferred the BNT162B2 (mRNA) vaccine. Pain at the site of vaccination (20%), fatigue (14%), myalgia (18%), headache (5%) and fever (4%) were side effects. When the side effects after the first dose were compared, the frequency of the side effects of mRNA vaccine was found to be significantly higher (71%) (P < 0.0001). Two (1.3%) of the patients after the first dose and 5 (3.8%) after the second dose had an MS attack. Conclusion: Inactive and mRNA vaccines showed similar side effects with the normal population in patients with MS, and there was no significant difference in the frequency of attacks between vaccines. |
| first_indexed | 2024-03-13T00:32:30Z |
| format | Article |
| id | doaj.art-fb182a9cdb3a4235b16ec13ca62b488e |
| institution | Directory Open Access Journal |
| issn | 1309-2545 |
| language | English |
| last_indexed | 2024-03-13T00:32:30Z |
| publishDate | 2023-06-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Nöroloji Dergisi |
| spelling | doaj.art-fb182a9cdb3a4235b16ec13ca62b488e2023-07-10T11:12:46ZengGalenos YayineviTürk Nöroloji Dergisi1309-25452023-06-0129210611010.4274/tnd.2022.97493TJN-97493Evaluation of Demographic, Clinical Characteristics and Side Effects in Multiple Sclerosis Patients Vaccinated Against SARS-CoV-2 VirusÖzgü Kizek0Gizem Yağmur Yalçın1Tuncay Gündüz2Murat Kürtüncü3Mefküre Eraksoy4Istanbul University, Istanbul Faculty of Medicine, Department of Neurology, Istanbul, TürkiyeIstanbul University, Istanbul Faculty of Medicine, Department of Neurology, Istanbul, TürkiyeIstanbul University, Istanbul Faculty of Medicine, Department of Neurology, Istanbul, TürkiyeIstanbul University, Istanbul Faculty of Medicine, Department of Neurology, Istanbul, TürkiyeIstanbul University, Istanbul Faculty of Medicine, Department of Neurology, Istanbul, TürkiyeObjective: Our primary objective in our study was to review the side effect of MS patients vaccinated against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) virus from Istanbul University, Istanbul Faculty of Medicine, Multiple Sclerosis and Myelin Diseases Outpatient Clinic. The secondary objective of our research was to evaluate the demographic, clinical characteristics and disease-modifying therapies of patients who have been infected with coronavirus disease-2019 (COVID-19) and who have been vaccinated against the SARS-CoV-2 virus. Materials and Methods: A questionnaire was sent via text message or e-mail to patients who were followed up at the Multiple Sclerosis and Myelin Diseases Outpatient Clinic of the Department of Neurology of the Istanbul University, Istanbul Faculty of Medicine. The eligibility criteria were not being in the period of an attack and being volunteered to participate in the study. A questionnaire consisting of a total of 21 questions was answered by the patients and the results of 160 patients were evaluated statistically. Results: One hundred and seven of the 160 patients were women (67%), and 53 (33%) men. The mean age of the patients was 38 +- 10.9 years. As a majority of the patients, 128 of the patients (80%) were followed up with a diagnosis of relapsing remmitting multiple sclerosis (MS). The rate of COVID-19 infection among the patients was 17% (n = 27). 67.5% (n = 108) of the patients preferred the inactive SARS-CoV-2 vaccine, while 31.8% (n = 51) preferred the BNT162B2 (mRNA) vaccine. Pain at the site of vaccination (20%), fatigue (14%), myalgia (18%), headache (5%) and fever (4%) were side effects. When the side effects after the first dose were compared, the frequency of the side effects of mRNA vaccine was found to be significantly higher (71%) (P < 0.0001). Two (1.3%) of the patients after the first dose and 5 (3.8%) after the second dose had an MS attack. Conclusion: Inactive and mRNA vaccines showed similar side effects with the normal population in patients with MS, and there was no significant difference in the frequency of attacks between vaccines.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjn&un=TJN-97493multiple sclerosissars-cov-2vaccinationside effects |
| spellingShingle | Özgü Kizek Gizem Yağmur Yalçın Tuncay Gündüz Murat Kürtüncü Mefküre Eraksoy Evaluation of Demographic, Clinical Characteristics and Side Effects in Multiple Sclerosis Patients Vaccinated Against SARS-CoV-2 Virus Türk Nöroloji Dergisi multiple sclerosis sars-cov-2 vaccination side effects |
| title | Evaluation of Demographic, Clinical Characteristics and Side Effects in Multiple Sclerosis Patients Vaccinated Against SARS-CoV-2 Virus |
| title_full | Evaluation of Demographic, Clinical Characteristics and Side Effects in Multiple Sclerosis Patients Vaccinated Against SARS-CoV-2 Virus |
| title_fullStr | Evaluation of Demographic, Clinical Characteristics and Side Effects in Multiple Sclerosis Patients Vaccinated Against SARS-CoV-2 Virus |
| title_full_unstemmed | Evaluation of Demographic, Clinical Characteristics and Side Effects in Multiple Sclerosis Patients Vaccinated Against SARS-CoV-2 Virus |
| title_short | Evaluation of Demographic, Clinical Characteristics and Side Effects in Multiple Sclerosis Patients Vaccinated Against SARS-CoV-2 Virus |
| title_sort | evaluation of demographic clinical characteristics and side effects in multiple sclerosis patients vaccinated against sars cov 2 virus |
| topic | multiple sclerosis sars-cov-2 vaccination side effects |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjn&un=TJN-97493 |
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