Disinhibition-Like Behavior Correlates with Frontal Cortex Damage in an Animal Model of Chronic Alcohol Consumption and Thiamine Deficiency

Disinhibition-Like Behavior Correlates with Frontal Cortex Damage in an Animal Model of Chronic Alcohol Consumption and Thiamine Deficiency

Wernicke–Korsakoff syndrome (WKS) is induced by thiamine deficiency (TD) and mainly related to alcohol consumption. Frontal cortex dysfunction has been associated with impulsivity and disinhibition in WKS patients. The pathophysiology involves oxidative stress, excitotoxicity and inflammatory respon...

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Bibliographic Details
Main Authors: Marta Moya, Leticia López-Valencia, Borja García-Bueno, Laura Orio
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Biomedicines
Subjects:
chronic alcohol
thiamine deficiency
disinhibition
Wernicke’s encephalopathy
recognition memory
nitrosative stress
Online Access:https://www.mdpi.com/2227-9059/10/2/260

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