Epilepsy and Autism Spectrum Disorder: An Epidemiological Study in Shanghai, China
Autism spectrum disorder (ASD) is a neurodevelopmental disease that may involve various brain abnormalities. However, there are few large epidemiological studies on the relation between epilepsy and ASD in terms of different genders and ages. This study aimed to evaluate the relation between epileps...
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Frontiers Media S.A.
2019-09-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00658/full |
| _version_ | 1818295522722578432 |
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| author | Anyi Zhang Anyi Zhang Anyi Zhang Jijun Li Yiwen Zhang Yiwen Zhang Yiwen Zhang Xingming Jin Xingming Jin Xingming Jin Jun Ma Jun Ma Jun Ma |
| author_facet | Anyi Zhang Anyi Zhang Anyi Zhang Jijun Li Yiwen Zhang Yiwen Zhang Yiwen Zhang Xingming Jin Xingming Jin Xingming Jin Jun Ma Jun Ma Jun Ma |
| author_sort | Anyi Zhang |
| collection | DOAJ |
| description | Autism spectrum disorder (ASD) is a neurodevelopmental disease that may involve various brain abnormalities. However, there are few large epidemiological studies on the relation between epilepsy and ASD in terms of different genders and ages. This study aimed to evaluate the relation between epilepsy and ASD based on 74,251 Chinese children aged 3–12 years who were recruited from kindergartens and primary schools in China. ASD was diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders—Fifth Edition (DSM-V), and verification of epilepsy was based on medical records. The enrolled children diagnosed with ASD were examined by magnetic resonance imaging (MRI) and took genetic tests to rule out other neurological and congenital diseases. The raw odds ratio (OR) was 60.53 [95% confidence interval (CI) = 37.80–96.92, P < 0.01] for epilepsy and ASD, and the adjusted OR was 38.99 (95% CI = 20.70–73.41, P < 0.01) after controlling for the confounders. Moreover, the adjusted OR was significantly higher in girls (OR = 45.26, 95% CI = 16.42–124.76, P < 0.01) than in boys (OR = 32.64, 95% CI = 14.33–74.34, P < 0.01). Among children with younger age, the adjusted OR was the highest (OR = 75.12, 95% CI = 22.80–247.48.16, P < 0.01). These findings suggest that epilepsy might be closely linked to the development of ASD, especially for early-onset epilepsy and among girls. |
| first_indexed | 2024-12-13T03:48:59Z |
| format | Article |
| id | doaj.art-fb19fbd679df42a8a00d98170fa1c92e |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-13T03:48:59Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-fb19fbd679df42a8a00d98170fa1c92e2022-12-22T00:00:45ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402019-09-011010.3389/fpsyt.2019.00658415319Epilepsy and Autism Spectrum Disorder: An Epidemiological Study in Shanghai, ChinaAnyi Zhang0Anyi Zhang1Anyi Zhang2Jijun Li3Yiwen Zhang4Yiwen Zhang5Yiwen Zhang6Xingming Jin7Xingming Jin8Xingming Jin9Jun Ma10Jun Ma11Jun Ma12Department of Developmental and Behavioral Pediatrics, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMOE-Shanghai Key Laboratory of Children’s Environmental Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Institute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Integrative Medicine on Pediatrics, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Developmental and Behavioral Pediatrics, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMOE-Shanghai Key Laboratory of Children’s Environmental Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Institute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Developmental and Behavioral Pediatrics, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMOE-Shanghai Key Laboratory of Children’s Environmental Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Institute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Developmental and Behavioral Pediatrics, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMOE-Shanghai Key Laboratory of Children’s Environmental Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Institute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaAutism spectrum disorder (ASD) is a neurodevelopmental disease that may involve various brain abnormalities. However, there are few large epidemiological studies on the relation between epilepsy and ASD in terms of different genders and ages. This study aimed to evaluate the relation between epilepsy and ASD based on 74,251 Chinese children aged 3–12 years who were recruited from kindergartens and primary schools in China. ASD was diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders—Fifth Edition (DSM-V), and verification of epilepsy was based on medical records. The enrolled children diagnosed with ASD were examined by magnetic resonance imaging (MRI) and took genetic tests to rule out other neurological and congenital diseases. The raw odds ratio (OR) was 60.53 [95% confidence interval (CI) = 37.80–96.92, P < 0.01] for epilepsy and ASD, and the adjusted OR was 38.99 (95% CI = 20.70–73.41, P < 0.01) after controlling for the confounders. Moreover, the adjusted OR was significantly higher in girls (OR = 45.26, 95% CI = 16.42–124.76, P < 0.01) than in boys (OR = 32.64, 95% CI = 14.33–74.34, P < 0.01). Among children with younger age, the adjusted OR was the highest (OR = 75.12, 95% CI = 22.80–247.48.16, P < 0.01). These findings suggest that epilepsy might be closely linked to the development of ASD, especially for early-onset epilepsy and among girls.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00658/fullautism spectrum disorderageepilepsygendersocial function neural network |
| spellingShingle | Anyi Zhang Anyi Zhang Anyi Zhang Jijun Li Yiwen Zhang Yiwen Zhang Yiwen Zhang Xingming Jin Xingming Jin Xingming Jin Jun Ma Jun Ma Jun Ma Epilepsy and Autism Spectrum Disorder: An Epidemiological Study in Shanghai, China Frontiers in Psychiatry autism spectrum disorder age epilepsy gender social function neural network |
| title | Epilepsy and Autism Spectrum Disorder: An Epidemiological Study in Shanghai, China |
| title_full | Epilepsy and Autism Spectrum Disorder: An Epidemiological Study in Shanghai, China |
| title_fullStr | Epilepsy and Autism Spectrum Disorder: An Epidemiological Study in Shanghai, China |
| title_full_unstemmed | Epilepsy and Autism Spectrum Disorder: An Epidemiological Study in Shanghai, China |
| title_short | Epilepsy and Autism Spectrum Disorder: An Epidemiological Study in Shanghai, China |
| title_sort | epilepsy and autism spectrum disorder an epidemiological study in shanghai china |
| topic | autism spectrum disorder age epilepsy gender social function neural network |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00658/full |
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