Retinaldehyde Dehydrogenase Inhibition-Related Adverse Outcome Pathway: Potential Risk of Retinoic Acid Synthesis Inhibition during Embryogenesis

Retinaldehyde Dehydrogenase Inhibition-Related Adverse Outcome Pathway: Potential Risk of Retinoic Acid Synthesis Inhibition during Embryogenesis

Retinoic acid (RA) is one of the factors crucial for cell growth, differentiation, and embryogenesis; it interacts with the retinoic acid receptor and retinoic acid X receptor to eventually regulate target gene expression in chordates. RA is transformed from retinaldehyde via oxidization by retinald...

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Bibliographic Details
Main Authors: Kichul Cho, Sang-Moo Lee, Jina Heo, Yong Min Kwon, Dawoon Chung, Woon-Jong Yu, Seung Seob Bae, Grace Choi, Dae-Sung Lee, Youngjun Kim
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Toxins
Subjects:
adverse outcome pathway
retinaldehyde dehydrogenase
retinoic acid
embryogenesis
toxicity
Online Access:https://www.mdpi.com/2072-6651/13/11/739

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