An essential cell-autonomous role for hepcidin in cardiac iron homeostasis
Hepcidin is the master regulator of systemic iron homeostasis. Derived primarily from the liver, it inhibits the iron exporter ferroportin in the gut and spleen, the sites of iron absorption and recycling respectively. Recently, we demonstrated that ferroportin is also found in cardiomyocytes, and t...
Main Authors: | Samira Lakhal-Littleton, Magda Wolna, Yu Jin Chung, Helen C Christian, Lisa C Heather, Marcella Brescia, Vicky Ball, Rebeca Diaz, Ana Santos, Daniel Biggs, Kieran Clarke, Benjamin Davies, Peter A Robbins |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2016-11-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/19804 |
Similar Items
-
Does Hepcidin Tuning Have a Role among Emerging Treatments for Thalassemia?
by: Filomena Longo, et al.
Published: (2022-08-01) -
Heart Ferroportin Protein Content Is Regulated by Heart Iron Concentration and Systemic Hepcidin Expression
by: Betty Berezovsky, et al.
Published: (2022-05-01) -
Identification of Antibody and Small Molecule Antagonists of Ferroportin-Hepcidin Interaction
by: Sandra L. Ross, et al.
Published: (2017-11-01) -
Impaired iron recycling from erythrocytes is an early hallmark of aging
by: Patryk Slusarczyk, et al.
Published: (2023-01-01) -
Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic <i>N</i>-Methylated Mini-Hepcidins
by: Daniela Goncalves Monteiro, et al.
Published: (2021-02-01)