Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad
Research focused on succinate dehydrogenase (SDH) and its substrate, succinate, culminated in the 1950s accompanying the rapid development of research dedicated to bioenergetics and intermediary metabolism. This allowed researchers to uncover the implication of SDH in both the mitochondrial respirat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/8/1788 |
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| author | Paule Bénit Judith Goncalves Riyad El Khoury Malgorzata Rak Judith Favier Anne-Paule Gimenez-Roqueplo Pierre Rustin |
| author_facet | Paule Bénit Judith Goncalves Riyad El Khoury Malgorzata Rak Judith Favier Anne-Paule Gimenez-Roqueplo Pierre Rustin |
| author_sort | Paule Bénit |
| collection | DOAJ |
| description | Research focused on succinate dehydrogenase (SDH) and its substrate, succinate, culminated in the 1950s accompanying the rapid development of research dedicated to bioenergetics and intermediary metabolism. This allowed researchers to uncover the implication of SDH in both the mitochondrial respiratory chain and the Krebs cycle. Nowadays, this theme is experiencing a real revival following the discovery of the role of SDH and succinate in a subset of tumors and cancers in humans. The aim of this review is to enlighten the many questions yet unanswered, ranging from fundamental to clinically oriented aspects, up to the danger of the current use of SDH as a target for a subclass of pesticides. |
| first_indexed | 2024-03-09T10:01:00Z |
| format | Article |
| id | doaj.art-fb1bca52e480479c8de00d10783417b0 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T10:01:00Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-fb1bca52e480479c8de00d10783417b02023-12-01T23:26:53ZengMDPI AGBiomedicines2227-90592022-07-01108178810.3390/biomedicines10081788Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive CrossroadPaule Bénit0Judith Goncalves1Riyad El Khoury2Malgorzata Rak3Judith Favier4Anne-Paule Gimenez-Roqueplo5Pierre Rustin6NeuroDiderot, Inserm, Université Paris Cité, F-75019 Paris, FranceParis Centre de Recherche Cardiovasculaire (PARCC), Inserm, Université Paris Cité, F-75015 Paris, FranceDepartment of Pathology and Laboratory Medicine, Neuromuscular Diagnostic Laboratory, American University of Beirut Medical Center, Beirut 1107 2020, LebanonNeuroDiderot, Inserm, Université Paris Cité, F-75019 Paris, FranceParis Centre de Recherche Cardiovasculaire (PARCC), Inserm, Université Paris Cité, F-75015 Paris, FranceDépartement de Médecine Génomique des Tumeurs et des Cancers, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou, F-75015 Paris, FranceNeuroDiderot, Inserm, Université Paris Cité, F-75019 Paris, FranceResearch focused on succinate dehydrogenase (SDH) and its substrate, succinate, culminated in the 1950s accompanying the rapid development of research dedicated to bioenergetics and intermediary metabolism. This allowed researchers to uncover the implication of SDH in both the mitochondrial respiratory chain and the Krebs cycle. Nowadays, this theme is experiencing a real revival following the discovery of the role of SDH and succinate in a subset of tumors and cancers in humans. The aim of this review is to enlighten the many questions yet unanswered, ranging from fundamental to clinically oriented aspects, up to the danger of the current use of SDH as a target for a subclass of pesticides.https://www.mdpi.com/2227-9059/10/8/1788mitochondriarespiratory chainKrebs cyclesuccinatecancerencephalopathy |
| spellingShingle | Paule Bénit Judith Goncalves Riyad El Khoury Malgorzata Rak Judith Favier Anne-Paule Gimenez-Roqueplo Pierre Rustin Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad Biomedicines mitochondria respiratory chain Krebs cycle succinate cancer encephalopathy |
| title | Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad |
| title_full | Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad |
| title_fullStr | Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad |
| title_full_unstemmed | Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad |
| title_short | Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad |
| title_sort | succinate dehydrogenase succinate and superoxides a genetic epigenetic metabolic environmental explosive crossroad |
| topic | mitochondria respiratory chain Krebs cycle succinate cancer encephalopathy |
| url | https://www.mdpi.com/2227-9059/10/8/1788 |
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