Diagnostic value of circulating lncRNAs for gastric cancer: A systematic review and meta-analysis
ObjectiveWith the prevalence of next-generation sequencing (NGS) technology, a large number of long non-coding RNAs (lncRNAs) have attracted tremendous attention and have been the topic of extensive research on gastric cancer (GC). It was revealed that lncRNAs not only participate in the transductio...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1058028/full |
| _version_ | 1811314438634995712 |
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| author | Jian Li Yanyan Zhang Qingyu Xu Yaqiong Zhang Songhua Bei Ying Ding Xiaohong Zhang Li Feng |
| author_facet | Jian Li Yanyan Zhang Qingyu Xu Yaqiong Zhang Songhua Bei Ying Ding Xiaohong Zhang Li Feng |
| author_sort | Jian Li |
| collection | DOAJ |
| description | ObjectiveWith the prevalence of next-generation sequencing (NGS) technology, a large number of long non-coding RNAs (lncRNAs) have attracted tremendous attention and have been the topic of extensive research on gastric cancer (GC). It was revealed that lncRNAs not only participate in the transduction of various signaling pathways, thus influencing GC genesis and development, but also have the potential for GC diagnosis. Therefore, we aimed to conduct a meta-analysis of previous studies on GC.Materials and methodsAn electronic search was made before August 2021 on databases including PubMed, Embase, and Web of Science. Relevant articles that compare lncRNA expression in GC patients and healthy controls were summarized. We conducted a meta-analysis with the objective of evaluating the ability of lncRNAs in diagnosing GC.ResultsA total of 40 original research studies including 6,772 participants were discussed in this meta-analysis. The overall sensitivity, specificity, and the area under the curve (AUC) were 0.78 (95% CI: 0.75–0.81), 0.79 (95% CI: 0.74–0.83), and 0.85 (95% CI: 0.81–0.87), respectively. The value of pooled diagnostic odds ratios (DORs) was 13.00 (95% CI: 10.00–17.00).ConclusionsThis meta-analysis revealed that serum or plasma lncRNAs have high sensitivity and specificity, which makes lncRNAs clinically feasible in diagnosing GC. The results from this meta-analysis demonstrated that peripheral blood lncRNAs may become novel noninvasive biomarkers in the foreseeable future. At the same time, it should be noted that a greater number of blood samples and more evidence from rigorous multicenter clinical studies are necessary to justify their applicability as cancer biomarkers. |
| first_indexed | 2024-04-13T11:12:50Z |
| format | Article |
| id | doaj.art-fb1db21902f7444ca96cb8f947a7eba6 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T11:12:50Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-fb1db21902f7444ca96cb8f947a7eba62022-12-22T02:49:05ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-12-011210.3389/fonc.2022.10580281058028Diagnostic value of circulating lncRNAs for gastric cancer: A systematic review and meta-analysisJian LiYanyan ZhangQingyu XuYaqiong ZhangSonghua BeiYing DingXiaohong ZhangLi FengObjectiveWith the prevalence of next-generation sequencing (NGS) technology, a large number of long non-coding RNAs (lncRNAs) have attracted tremendous attention and have been the topic of extensive research on gastric cancer (GC). It was revealed that lncRNAs not only participate in the transduction of various signaling pathways, thus influencing GC genesis and development, but also have the potential for GC diagnosis. Therefore, we aimed to conduct a meta-analysis of previous studies on GC.Materials and methodsAn electronic search was made before August 2021 on databases including PubMed, Embase, and Web of Science. Relevant articles that compare lncRNA expression in GC patients and healthy controls were summarized. We conducted a meta-analysis with the objective of evaluating the ability of lncRNAs in diagnosing GC.ResultsA total of 40 original research studies including 6,772 participants were discussed in this meta-analysis. The overall sensitivity, specificity, and the area under the curve (AUC) were 0.78 (95% CI: 0.75–0.81), 0.79 (95% CI: 0.74–0.83), and 0.85 (95% CI: 0.81–0.87), respectively. The value of pooled diagnostic odds ratios (DORs) was 13.00 (95% CI: 10.00–17.00).ConclusionsThis meta-analysis revealed that serum or plasma lncRNAs have high sensitivity and specificity, which makes lncRNAs clinically feasible in diagnosing GC. The results from this meta-analysis demonstrated that peripheral blood lncRNAs may become novel noninvasive biomarkers in the foreseeable future. At the same time, it should be noted that a greater number of blood samples and more evidence from rigorous multicenter clinical studies are necessary to justify their applicability as cancer biomarkers.https://www.frontiersin.org/articles/10.3389/fonc.2022.1058028/fullgastric cancerlncRNAdiagnosissystematic reviewmeta - analysis |
| spellingShingle | Jian Li Yanyan Zhang Qingyu Xu Yaqiong Zhang Songhua Bei Ying Ding Xiaohong Zhang Li Feng Diagnostic value of circulating lncRNAs for gastric cancer: A systematic review and meta-analysis Frontiers in Oncology gastric cancer lncRNA diagnosis systematic review meta - analysis |
| title | Diagnostic value of circulating lncRNAs for gastric cancer: A systematic review and meta-analysis |
| title_full | Diagnostic value of circulating lncRNAs for gastric cancer: A systematic review and meta-analysis |
| title_fullStr | Diagnostic value of circulating lncRNAs for gastric cancer: A systematic review and meta-analysis |
| title_full_unstemmed | Diagnostic value of circulating lncRNAs for gastric cancer: A systematic review and meta-analysis |
| title_short | Diagnostic value of circulating lncRNAs for gastric cancer: A systematic review and meta-analysis |
| title_sort | diagnostic value of circulating lncrnas for gastric cancer a systematic review and meta analysis |
| topic | gastric cancer lncRNA diagnosis systematic review meta - analysis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1058028/full |
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