The antioxidant and anticancer activity of Quercus coccifera plant leaves extracts
Quercus species are one of the medicinal plants that commonly used in the treatment of different diseases. Quercus coccifera (Q. coccifera) is part of the Quercus species which grow in Jordan and used in traditional folklore medicine. The aim of this study is to confirm the ability of (Q. coccifera)...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-05-01
|
| Series: | Saudi Journal of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319562X24000573 |
| _version_ | 1797213495833395200 |
|---|---|
| author | Saif Aldeen Jaber |
| author_facet | Saif Aldeen Jaber |
| author_sort | Saif Aldeen Jaber |
| collection | DOAJ |
| description | Quercus species are one of the medicinal plants that commonly used in the treatment of different diseases. Quercus coccifera (Q. coccifera) is part of the Quercus species which grow in Jordan and used in traditional folklore medicine. The aim of this study is to confirm the ability of (Q. coccifera) leaves extracts to exert anticancer activity.In this study, an extraction method of the dried-leaves using different polarity solvents was used. Extracts were pre-evaluated for antioxidant and anticancer activities while active extracts were used to measure half maximal effective concentration (EC50) against 2,2-Diphenyl-1-picrylhydrazyl (DPPH), and Half-maximal inhibitory concentration (IC50) against cancer cells.Methanol, boiled and microwaved water extracts had greater than 80 % antioxidant activity, and the strongest activity, of more than 99 %, was boiled water extract. Similarly, the pre-evaluation treatments of cancer cell lines indicated a strong biological activity of more than 70 % from the previously mentioned extracts, and the highest activity, of greater than 90 %, was from boiled water extracts against all cancer cell lines. The highest EC50 against DPPH was obtained by using 0.009 mg/ml boiled water extracts, which was lower than positive control quercetin. In the same manner, lung, breast, and prostate cancer cell lines were highly affected by boiled water extracts with IC50 of 14.1, 7.2, and 25.1 µg/ml, respectively, and a selectivity index (SI) of greater than 4.71.Q. coccifera leaves extracts show promising ability to be a source of a new anticancer therapeutics. |
| first_indexed | 2024-04-24T10:59:12Z |
| format | Article |
| id | doaj.art-fb1df4b0255a4cdeaf53c570944f9908 |
| institution | Directory Open Access Journal |
| issn | 1319-562X |
| language | English |
| last_indexed | 2024-04-24T10:59:12Z |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Journal of Biological Sciences |
| spelling | doaj.art-fb1df4b0255a4cdeaf53c570944f99082024-04-12T04:44:26ZengElsevierSaudi Journal of Biological Sciences1319-562X2024-05-01315103979The antioxidant and anticancer activity of Quercus coccifera plant leaves extractsSaif Aldeen Jaber0Faculty of Pharmacy, Middle East University, Amman, Jordan; Applied Science Research Center, Applied Science Private University, Amman, JordanQuercus species are one of the medicinal plants that commonly used in the treatment of different diseases. Quercus coccifera (Q. coccifera) is part of the Quercus species which grow in Jordan and used in traditional folklore medicine. The aim of this study is to confirm the ability of (Q. coccifera) leaves extracts to exert anticancer activity.In this study, an extraction method of the dried-leaves using different polarity solvents was used. Extracts were pre-evaluated for antioxidant and anticancer activities while active extracts were used to measure half maximal effective concentration (EC50) against 2,2-Diphenyl-1-picrylhydrazyl (DPPH), and Half-maximal inhibitory concentration (IC50) against cancer cells.Methanol, boiled and microwaved water extracts had greater than 80 % antioxidant activity, and the strongest activity, of more than 99 %, was boiled water extract. Similarly, the pre-evaluation treatments of cancer cell lines indicated a strong biological activity of more than 70 % from the previously mentioned extracts, and the highest activity, of greater than 90 %, was from boiled water extracts against all cancer cell lines. The highest EC50 against DPPH was obtained by using 0.009 mg/ml boiled water extracts, which was lower than positive control quercetin. In the same manner, lung, breast, and prostate cancer cell lines were highly affected by boiled water extracts with IC50 of 14.1, 7.2, and 25.1 µg/ml, respectively, and a selectivity index (SI) of greater than 4.71.Q. coccifera leaves extracts show promising ability to be a source of a new anticancer therapeutics.http://www.sciencedirect.com/science/article/pii/S1319562X24000573AnticancerAntioxidantNew compoundsNatural ProductsDPPH |
| spellingShingle | Saif Aldeen Jaber The antioxidant and anticancer activity of Quercus coccifera plant leaves extracts Saudi Journal of Biological Sciences Anticancer Antioxidant New compounds Natural Products DPPH |
| title | The antioxidant and anticancer activity of Quercus coccifera plant leaves extracts |
| title_full | The antioxidant and anticancer activity of Quercus coccifera plant leaves extracts |
| title_fullStr | The antioxidant and anticancer activity of Quercus coccifera plant leaves extracts |
| title_full_unstemmed | The antioxidant and anticancer activity of Quercus coccifera plant leaves extracts |
| title_short | The antioxidant and anticancer activity of Quercus coccifera plant leaves extracts |
| title_sort | antioxidant and anticancer activity of quercus coccifera plant leaves extracts |
| topic | Anticancer Antioxidant New compounds Natural Products DPPH |
| url | http://www.sciencedirect.com/science/article/pii/S1319562X24000573 |
| work_keys_str_mv | AT saifaldeenjaber theantioxidantandanticanceractivityofquercuscocciferaplantleavesextracts AT saifaldeenjaber antioxidantandanticanceractivityofquercuscocciferaplantleavesextracts |