Early blastulation of day 4 embryo correlates with the increased euploid rate of preimplantation genetic screening cycles

Objective: It is known that embryos with faster growing potential, especially in blastocyst development, correlate with the increased euploid rate. Our study investigated the preimplantation genetic screening cycle to analyze the correlation between early blastulation (EB) on day 4 embryo and the eu...

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Main Authors: Tzu-Yu Hung, Robert Kuo-Kuang Lee, Yuh-Ming Hwu, Ming-Huei Lin, Ryh-Sheng Li, Yu-Wen Weng
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Taiwanese Journal of Obstetrics & Gynecology
Online Access:http://www.sciencedirect.com/science/article/pii/S1028455918302407
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author Tzu-Yu Hung
Robert Kuo-Kuang Lee
Yuh-Ming Hwu
Ming-Huei Lin
Ryh-Sheng Li
Yu-Wen Weng
author_facet Tzu-Yu Hung
Robert Kuo-Kuang Lee
Yuh-Ming Hwu
Ming-Huei Lin
Ryh-Sheng Li
Yu-Wen Weng
author_sort Tzu-Yu Hung
collection DOAJ
description Objective: It is known that embryos with faster growing potential, especially in blastocyst development, correlate with the increased euploid rate. Our study investigated the preimplantation genetic screening cycle to analyze the correlation between early blastulation (EB) on day 4 embryo and the euploid rate. Materials and methods: This is a retrospective study examining 273 biopsied blastocysts after preimplantation genetic screening obtained from 54 patients from March 2013 to March 2017. Of the 273 biopsied embryos, 81 had early blastulation on day 4 and were classified as the EB (+) group, while the other 192 had no early blastulation and were classified as the EB (−) group. Euploid rates were compared between the two groups. A total of 34 single euploid embryos were transferred, with 14 from the EB (+) group and 20 from the EB (−) group. Clinical pregnancy was compared between the groups. Results: There is a statistically significant increase in the euploid rate in the EB (+) group (49.4% vs. 34.4%, p = 0.02). The clinical pregnancy rate was also increased in the single euploid embryo transfer group with early blastulation, but did not reach statistical significance (71.4% vs. 50.0%, p = 0.211). Conclusions: Early blastulation of day 4 embryo correlates significantly with the euploid rate. Early blastulation of day 4 embryo may serve as a potential aid for embryo selection for transfer in preimplantation genetic screening cycles. Keywords: Blastocyst, Embryonic development, Preimplantation genetic screening, Pregnancy rate, Single embryo transfer
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spelling doaj.art-fb1e0b932027421f9d49407f801f44942022-12-22T03:15:34ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592018-12-01576858861Early blastulation of day 4 embryo correlates with the increased euploid rate of preimplantation genetic screening cyclesTzu-Yu Hung0Robert Kuo-Kuang Lee1Yuh-Ming Hwu2Ming-Huei Lin3Ryh-Sheng Li4Yu-Wen Weng5Department of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei, TaiwanDepartment of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei, Taiwan; Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, Taipei Medical University, Taipei, Taiwan; Corresponding author. Department of Obstetrics and Gynecology, Mackay Memorial Hospital, 92, Sec.2, Zhongshan N. Rd., Taipei, 104, Taiwan.Department of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei, Taiwan; Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan; MacKay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan; MacKay Medical College, New Taipei City, TaiwanDepartment of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei, Taiwan; Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan; MacKay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan; MacKay Medical College, New Taipei City, TaiwanDepartment of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei, TaiwanDepartment of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei, TaiwanObjective: It is known that embryos with faster growing potential, especially in blastocyst development, correlate with the increased euploid rate. Our study investigated the preimplantation genetic screening cycle to analyze the correlation between early blastulation (EB) on day 4 embryo and the euploid rate. Materials and methods: This is a retrospective study examining 273 biopsied blastocysts after preimplantation genetic screening obtained from 54 patients from March 2013 to March 2017. Of the 273 biopsied embryos, 81 had early blastulation on day 4 and were classified as the EB (+) group, while the other 192 had no early blastulation and were classified as the EB (−) group. Euploid rates were compared between the two groups. A total of 34 single euploid embryos were transferred, with 14 from the EB (+) group and 20 from the EB (−) group. Clinical pregnancy was compared between the groups. Results: There is a statistically significant increase in the euploid rate in the EB (+) group (49.4% vs. 34.4%, p = 0.02). The clinical pregnancy rate was also increased in the single euploid embryo transfer group with early blastulation, but did not reach statistical significance (71.4% vs. 50.0%, p = 0.211). Conclusions: Early blastulation of day 4 embryo correlates significantly with the euploid rate. Early blastulation of day 4 embryo may serve as a potential aid for embryo selection for transfer in preimplantation genetic screening cycles. Keywords: Blastocyst, Embryonic development, Preimplantation genetic screening, Pregnancy rate, Single embryo transferhttp://www.sciencedirect.com/science/article/pii/S1028455918302407
spellingShingle Tzu-Yu Hung
Robert Kuo-Kuang Lee
Yuh-Ming Hwu
Ming-Huei Lin
Ryh-Sheng Li
Yu-Wen Weng
Early blastulation of day 4 embryo correlates with the increased euploid rate of preimplantation genetic screening cycles
Taiwanese Journal of Obstetrics & Gynecology
title Early blastulation of day 4 embryo correlates with the increased euploid rate of preimplantation genetic screening cycles
title_full Early blastulation of day 4 embryo correlates with the increased euploid rate of preimplantation genetic screening cycles
title_fullStr Early blastulation of day 4 embryo correlates with the increased euploid rate of preimplantation genetic screening cycles
title_full_unstemmed Early blastulation of day 4 embryo correlates with the increased euploid rate of preimplantation genetic screening cycles
title_short Early blastulation of day 4 embryo correlates with the increased euploid rate of preimplantation genetic screening cycles
title_sort early blastulation of day 4 embryo correlates with the increased euploid rate of preimplantation genetic screening cycles
url http://www.sciencedirect.com/science/article/pii/S1028455918302407
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