Misfolded proteins: from little villains to little helpers in the fight against cancer
The application of cytostatic drugs targeting the high proliferation rates of cancer cells is currently the most commonly used treatment option in cancer chemotherapy. However, severe side effects and resistance mechanisms may occur as a result of such treatment, possibly limiting the therapeutic ef...
Main Authors: | Ansgar eBrüning, Julia eJückstock |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2015-02-01
|
Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00047/full |
Similar Items
-
The Anti-Cancer Properties of the HIV Protease Inhibitor Nelfinavir
by: Mahbuba R. Subeha, et al.
Published: (2020-11-01) -
Aggrephagy Deficiency in the Placenta: A New Pathogenesis of Preeclampsia
by: Akitoshi Nakashima, et al.
Published: (2021-02-01) -
Ethanol Exposure to Ethanol-Oxidizing HEPG2 Cells Induces Intracellular Protein Aggregation
by: Paul G. Thomes, et al.
Published: (2023-03-01) -
Nelfinavir Induces Cytotoxicity towards High-Grade Serous Ovarian Cancer Cells, Involving Induction of the Unfolded Protein Response, Modulation of Protein Synthesis, DNA Damage, Lysosomal Impairment, and Potentiation of Toxicity Caused by Proteasome Inhibition
by: Mahbuba R. Subeha, et al.
Published: (2021-12-01) -
Protein aggregation in neurodegenerative disease: the nucleolar connection
by: Leena Latonen
Published: (2015-07-01)