Role of protease‐activated receptor‐1 (PAR‐1) in the glomerular filtration barrier integrity

Role of protease‐activated receptor‐1 (PAR‐1) in the glomerular filtration barrier integrity

Abstract Protease‐activated receptors (PAR) play an important role in the regulation of cellular function by the coagulation system, and they are activated by thrombin. PAR‐1 is expressed in both endothelial cells and podocytes in the kidney. The role of PAR1 in the maintenance of the glomerular fil...

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Bibliographic Details
Main Authors: Ajay Medipally, Min Xiao, Laura Biederman, Anjali A. Satoskar, Iouri Ivanov, Brad Rovin, Samir Parikh, Bryce A. Kerlin, Sergey V. Brodsky
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Physiological Reports
Subjects:
anticoagulant related nephropathy
glomerular filtration barrier
PAR‐1
renal pathology
Online Access:https://doi.org/10.14814/phy2.15343

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