Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism with susceptibility to prostate cancer: an updated meta-analysis
Abstract Objective This meta-analysis aims to explore the association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and susceptibility to prostate cancer (PCa). Methods We searched studies related to ACE I/D polymorphism and susceptibility to PCa through PubM...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-11-01
|
| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-022-02812-x |
| _version_ | 1811233836393037824 |
|---|---|
| author | Jianhui Du Jianhua Lan Hai Yang Qiao Ying Guohua Huang Jian Mou Jia Long Zhenghua Qiao Qiyi Hu |
| author_facet | Jianhui Du Jianhua Lan Hai Yang Qiao Ying Guohua Huang Jian Mou Jia Long Zhenghua Qiao Qiyi Hu |
| author_sort | Jianhui Du |
| collection | DOAJ |
| description | Abstract Objective This meta-analysis aims to explore the association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and susceptibility to prostate cancer (PCa). Methods We searched studies related to ACE I/D polymorphism and susceptibility to PCa through PubMed, Web of Science, Embase, Cochrane Library, and Scopus databases from inception to June 1, 2022. Five gene models, including allelic, dominant, recessive, homozygote, and heterozygote models, were analyzed. The pooled odds ratio (OR) was calculated using Stata 15.0 software. Publication bias was judged by the funnel plot and Egger’s test, with the robustness of the findings verified by sensitivity analysis. Results Eight published articles (including ten studies) were identified. The pooled results showed that ACE I/D locus polymorphism was significantly correlated with the risk of PCa under all gene models except for the heterozygous model (D vs. I: OR= 1.58, 95% CI: 1.14–2.21; DD vs. DI+II: OR=1.68, 95% CI: 1.11–2.54; DD+DI vs. II: OR=1.76, 95% CI: 1.11–2.80; DI vs. II: OR= 1.44, 95% CI: 0.99–2.10; DD vs. II: OR= 2.12, 95% CI: 1.15–3.93). Subgroup analysis based on genotype frequencies in the control group meeting Hardy-Weinberg equilibrium showed statistically significant differences in all gene models. The funnel plot and Egger’s test indicated no publication bias. The sensitivity analysis verified the robustness of the conclusions obtained in this meta-analysis. Conclusion ACE I/D locus polymorphism correlates to PCa risk. Allele D, genotype DD+DI, and DD at the ACE I/D locus increase susceptibility to PCa and can therefore serve as a potential diagnostic and screening molecular marker for PCa patients. |
| first_indexed | 2024-04-12T11:26:01Z |
| format | Article |
| id | doaj.art-fb25138ef6ac4f7b83e1fd57a28bd765 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-04-12T11:26:01Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-fb25138ef6ac4f7b83e1fd57a28bd7652022-12-22T03:35:13ZengBMCWorld Journal of Surgical Oncology1477-78192022-11-012011910.1186/s12957-022-02812-xAssociation of angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism with susceptibility to prostate cancer: an updated meta-analysisJianhui Du0Jianhua Lan1Hai Yang2Qiao Ying3Guohua Huang4Jian Mou5Jia Long6Zhenghua Qiao7Qiyi Hu8Department of Urology, People’s Hospital of Guang’an CityDepartment of Urology, People’s Hospital of Guang’an CityDepartment of Urology, People’s Hospital of Guang’an CityDepartment of Urology, People’s Hospital of Guang’an CityDepartment of Urology, People’s Hospital of Guang’an CityDepartment of Urology, People’s Hospital of Guang’an CityDepartment of Urology, People’s Hospital of Guang’an DistrictDepartment of Urology, People’s Hospital of Guang’an DistrictDepartment of Urology, Affiliated Longhua People’s Hospital, Southern Medical University (Longhua People’s Hospital)Abstract Objective This meta-analysis aims to explore the association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and susceptibility to prostate cancer (PCa). Methods We searched studies related to ACE I/D polymorphism and susceptibility to PCa through PubMed, Web of Science, Embase, Cochrane Library, and Scopus databases from inception to June 1, 2022. Five gene models, including allelic, dominant, recessive, homozygote, and heterozygote models, were analyzed. The pooled odds ratio (OR) was calculated using Stata 15.0 software. Publication bias was judged by the funnel plot and Egger’s test, with the robustness of the findings verified by sensitivity analysis. Results Eight published articles (including ten studies) were identified. The pooled results showed that ACE I/D locus polymorphism was significantly correlated with the risk of PCa under all gene models except for the heterozygous model (D vs. I: OR= 1.58, 95% CI: 1.14–2.21; DD vs. DI+II: OR=1.68, 95% CI: 1.11–2.54; DD+DI vs. II: OR=1.76, 95% CI: 1.11–2.80; DI vs. II: OR= 1.44, 95% CI: 0.99–2.10; DD vs. II: OR= 2.12, 95% CI: 1.15–3.93). Subgroup analysis based on genotype frequencies in the control group meeting Hardy-Weinberg equilibrium showed statistically significant differences in all gene models. The funnel plot and Egger’s test indicated no publication bias. The sensitivity analysis verified the robustness of the conclusions obtained in this meta-analysis. Conclusion ACE I/D locus polymorphism correlates to PCa risk. Allele D, genotype DD+DI, and DD at the ACE I/D locus increase susceptibility to PCa and can therefore serve as a potential diagnostic and screening molecular marker for PCa patients.https://doi.org/10.1186/s12957-022-02812-xAngiotensin-converting enzyme (ACE)SusceptibilityProstate cancerMeta-analysis |
| spellingShingle | Jianhui Du Jianhua Lan Hai Yang Qiao Ying Guohua Huang Jian Mou Jia Long Zhenghua Qiao Qiyi Hu Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism with susceptibility to prostate cancer: an updated meta-analysis World Journal of Surgical Oncology Angiotensin-converting enzyme (ACE) Susceptibility Prostate cancer Meta-analysis |
| title | Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism with susceptibility to prostate cancer: an updated meta-analysis |
| title_full | Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism with susceptibility to prostate cancer: an updated meta-analysis |
| title_fullStr | Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism with susceptibility to prostate cancer: an updated meta-analysis |
| title_full_unstemmed | Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism with susceptibility to prostate cancer: an updated meta-analysis |
| title_short | Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism with susceptibility to prostate cancer: an updated meta-analysis |
| title_sort | association of angiotensin converting enzyme insertion deletion ace i d gene polymorphism with susceptibility to prostate cancer an updated meta analysis |
| topic | Angiotensin-converting enzyme (ACE) Susceptibility Prostate cancer Meta-analysis |
| url | https://doi.org/10.1186/s12957-022-02812-x |
| work_keys_str_mv | AT jianhuidu associationofangiotensinconvertingenzymeinsertiondeletionaceidgenepolymorphismwithsusceptibilitytoprostatecanceranupdatedmetaanalysis AT jianhualan associationofangiotensinconvertingenzymeinsertiondeletionaceidgenepolymorphismwithsusceptibilitytoprostatecanceranupdatedmetaanalysis AT haiyang associationofangiotensinconvertingenzymeinsertiondeletionaceidgenepolymorphismwithsusceptibilitytoprostatecanceranupdatedmetaanalysis AT qiaoying associationofangiotensinconvertingenzymeinsertiondeletionaceidgenepolymorphismwithsusceptibilitytoprostatecanceranupdatedmetaanalysis AT guohuahuang associationofangiotensinconvertingenzymeinsertiondeletionaceidgenepolymorphismwithsusceptibilitytoprostatecanceranupdatedmetaanalysis AT jianmou associationofangiotensinconvertingenzymeinsertiondeletionaceidgenepolymorphismwithsusceptibilitytoprostatecanceranupdatedmetaanalysis AT jialong associationofangiotensinconvertingenzymeinsertiondeletionaceidgenepolymorphismwithsusceptibilitytoprostatecanceranupdatedmetaanalysis AT zhenghuaqiao associationofangiotensinconvertingenzymeinsertiondeletionaceidgenepolymorphismwithsusceptibilitytoprostatecanceranupdatedmetaanalysis AT qiyihu associationofangiotensinconvertingenzymeinsertiondeletionaceidgenepolymorphismwithsusceptibilitytoprostatecanceranupdatedmetaanalysis |