Resveratrol in Liquor Exacerbates Alcoholic Liver Injury with a Reduced Therapeutic Effect in Mice: An Unsupervised Herbal Wine Habit Is Risky
People in Eastern countries hold a tradition of soaking herbal medicine in wine; however, the efficacy and safety of herbal wine have not been rigorously assessed. By assessing the efficacy of resveratrol (RSV) in ethanol against alcoholic liver disease (ALD) in mice, we aimed to offer a perspective...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/22/4752 |
| _version_ | 1797464328008368128 |
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| author | Songxia Zhang Ying Xu Mengling Ye Wenli Ye Jian Xiao Honghao Zhou Wei Zhang Yan Shu Yun Huang Yao Chen |
| author_facet | Songxia Zhang Ying Xu Mengling Ye Wenli Ye Jian Xiao Honghao Zhou Wei Zhang Yan Shu Yun Huang Yao Chen |
| author_sort | Songxia Zhang |
| collection | DOAJ |
| description | People in Eastern countries hold a tradition of soaking herbal medicine in wine; however, the efficacy and safety of herbal wine have not been rigorously assessed. By assessing the efficacy of resveratrol (RSV) in ethanol against alcoholic liver disease (ALD) in mice, we aimed to offer a perspective on the use of herbal wine. To simulate the behaviour of herbal wine users, RSV (15 mg/kg) soaked in ethanol (RSV-alcohol) was administrated via gavage to the mice, here with alcohol consumption-induced ALD. RSV soaked in water (RSV-water) was the treatment control. The efficacy and safety of RSV on ALD were evaluated. Compared with the RSV-water group, a higher rate of mortality was found in the RSV-alcohol group (50.0% vs. 20.0%), which also exhibited more severe liver injury. RSV significantly increased the exposure of alcohol by 126.0%, which was accompanied by a significant inhibition of the ethanol metabolic pathway. In contrast, alcohol consumption significantly reduced exposure to RSV by 95.0%. Alcohol consumption had little effect on the expression of drug-metabolizing enzymes in RSV; however, alcohol seemed to reduce the absorption of RSV. RSV in liquor exacerbates alcoholic liver injury and has a reduced therapeutic effect, suggesting that the habit of herbal wine use without supervision is risky. |
| first_indexed | 2024-03-09T18:06:33Z |
| format | Article |
| id | doaj.art-fb25acb47044434bbb5166ca45b1dc79 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T18:06:33Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-fb25acb47044434bbb5166ca45b1dc792023-11-24T09:30:34ZengMDPI AGNutrients2072-66432022-11-011422475210.3390/nu14224752Resveratrol in Liquor Exacerbates Alcoholic Liver Injury with a Reduced Therapeutic Effect in Mice: An Unsupervised Herbal Wine Habit Is RiskySongxia Zhang0Ying Xu1Mengling Ye2Wenli Ye3Jian Xiao4Honghao Zhou5Wei Zhang6Yan Shu7Yun Huang8Yao Chen9Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USADepartment of Hepatobiliary Surgery, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, ChinaPeople in Eastern countries hold a tradition of soaking herbal medicine in wine; however, the efficacy and safety of herbal wine have not been rigorously assessed. By assessing the efficacy of resveratrol (RSV) in ethanol against alcoholic liver disease (ALD) in mice, we aimed to offer a perspective on the use of herbal wine. To simulate the behaviour of herbal wine users, RSV (15 mg/kg) soaked in ethanol (RSV-alcohol) was administrated via gavage to the mice, here with alcohol consumption-induced ALD. RSV soaked in water (RSV-water) was the treatment control. The efficacy and safety of RSV on ALD were evaluated. Compared with the RSV-water group, a higher rate of mortality was found in the RSV-alcohol group (50.0% vs. 20.0%), which also exhibited more severe liver injury. RSV significantly increased the exposure of alcohol by 126.0%, which was accompanied by a significant inhibition of the ethanol metabolic pathway. In contrast, alcohol consumption significantly reduced exposure to RSV by 95.0%. Alcohol consumption had little effect on the expression of drug-metabolizing enzymes in RSV; however, alcohol seemed to reduce the absorption of RSV. RSV in liquor exacerbates alcoholic liver injury and has a reduced therapeutic effect, suggesting that the habit of herbal wine use without supervision is risky.https://www.mdpi.com/2072-6643/14/22/4752herbal wine useresveratrolethanolconcomitant administrationliver injury |
| spellingShingle | Songxia Zhang Ying Xu Mengling Ye Wenli Ye Jian Xiao Honghao Zhou Wei Zhang Yan Shu Yun Huang Yao Chen Resveratrol in Liquor Exacerbates Alcoholic Liver Injury with a Reduced Therapeutic Effect in Mice: An Unsupervised Herbal Wine Habit Is Risky Nutrients herbal wine use resveratrol ethanol concomitant administration liver injury |
| title | Resveratrol in Liquor Exacerbates Alcoholic Liver Injury with a Reduced Therapeutic Effect in Mice: An Unsupervised Herbal Wine Habit Is Risky |
| title_full | Resveratrol in Liquor Exacerbates Alcoholic Liver Injury with a Reduced Therapeutic Effect in Mice: An Unsupervised Herbal Wine Habit Is Risky |
| title_fullStr | Resveratrol in Liquor Exacerbates Alcoholic Liver Injury with a Reduced Therapeutic Effect in Mice: An Unsupervised Herbal Wine Habit Is Risky |
| title_full_unstemmed | Resveratrol in Liquor Exacerbates Alcoholic Liver Injury with a Reduced Therapeutic Effect in Mice: An Unsupervised Herbal Wine Habit Is Risky |
| title_short | Resveratrol in Liquor Exacerbates Alcoholic Liver Injury with a Reduced Therapeutic Effect in Mice: An Unsupervised Herbal Wine Habit Is Risky |
| title_sort | resveratrol in liquor exacerbates alcoholic liver injury with a reduced therapeutic effect in mice an unsupervised herbal wine habit is risky |
| topic | herbal wine use resveratrol ethanol concomitant administration liver injury |
| url | https://www.mdpi.com/2072-6643/14/22/4752 |
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