Anti-Obesity Effects of Combined <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> Extract in High-Fat Diet-Induced Obese Male Mice
Medicinal plants are widely used as supplements for the treatment of various diseases because of their few side-effects. Here, we examined the anti-obesity effects of a mixture extract of <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> (CR) in high-fat diet (HFD)-indu...
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MDPI AG
2021-11-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/11/11/3187 |
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| author | Eunkuk Park Chang-Gun Lee Hyoju Jeon Hyesoo Jeong Subin Yeo Yoonjoong Yong Seon-Yong Jeong |
| author_facet | Eunkuk Park Chang-Gun Lee Hyoju Jeon Hyesoo Jeong Subin Yeo Yoonjoong Yong Seon-Yong Jeong |
| author_sort | Eunkuk Park |
| collection | DOAJ |
| description | Medicinal plants are widely used as supplements for the treatment of various diseases because of their few side-effects. Here, we examined the anti-obesity effects of a mixture extract of <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> (CR) in high-fat diet (HFD)-induced obese male mice. Four week old male C57BL/6J mice were fed a normal diet (ND) or 60% high-fat diet (HFD) with different concentrations of CR extracts (75, 150, and 300 mg/kg/day) by oral administration for 12 weeks. CR extract administration prevented HFD-induced weight gain, hepatic steatosis, and adipocyte enlargement through the downregulation of adipogenesis-associated genes in obese male mice. In addition, CR administration improved the impaired glucose metabolism, insulin action, biochemical obesity parameters, and metabolic profiles in HFD-induced male mice. Consequently, the CR extract exhibited beneficial effects on HFD-induced systemic metabolic challenges. Taken together, our findings suggest that CR extract may be a potent therapeutic supplement for the treatment and prevention of obesity. |
| first_indexed | 2024-03-10T05:46:41Z |
| format | Article |
| id | doaj.art-fb26044f8b42484786c6c9bd49a7b0cc |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T05:46:41Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-fb26044f8b42484786c6c9bd49a7b0cc2023-11-22T22:06:45ZengMDPI AGAnimals2076-26152021-11-011111318710.3390/ani11113187Anti-Obesity Effects of Combined <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> Extract in High-Fat Diet-Induced Obese Male MiceEunkuk Park0Chang-Gun Lee1Hyoju Jeon2Hyesoo Jeong3Subin Yeo4Yoonjoong Yong5Seon-Yong Jeong6Department of Medical Genetics, Ajou University School of Medicine, Suwon 16499, KoreaDepartment of Medical Genetics, Ajou University School of Medicine, Suwon 16499, KoreaDepartment of Medical Genetics, Ajou University School of Medicine, Suwon 16499, KoreaNine B Company, Daejeon 34121, KoreaNine B Company, Daejeon 34121, KoreaNine B Company, Daejeon 34121, KoreaDepartment of Medical Genetics, Ajou University School of Medicine, Suwon 16499, KoreaMedicinal plants are widely used as supplements for the treatment of various diseases because of their few side-effects. Here, we examined the anti-obesity effects of a mixture extract of <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> (CR) in high-fat diet (HFD)-induced obese male mice. Four week old male C57BL/6J mice were fed a normal diet (ND) or 60% high-fat diet (HFD) with different concentrations of CR extracts (75, 150, and 300 mg/kg/day) by oral administration for 12 weeks. CR extract administration prevented HFD-induced weight gain, hepatic steatosis, and adipocyte enlargement through the downregulation of adipogenesis-associated genes in obese male mice. In addition, CR administration improved the impaired glucose metabolism, insulin action, biochemical obesity parameters, and metabolic profiles in HFD-induced male mice. Consequently, the CR extract exhibited beneficial effects on HFD-induced systemic metabolic challenges. Taken together, our findings suggest that CR extract may be a potent therapeutic supplement for the treatment and prevention of obesity.https://www.mdpi.com/2076-2615/11/11/3187anti-obesity<i>Cornus officinalis</i><i>Ribes fasciculatum</i>high-fat dietobese male mice |
| spellingShingle | Eunkuk Park Chang-Gun Lee Hyoju Jeon Hyesoo Jeong Subin Yeo Yoonjoong Yong Seon-Yong Jeong Anti-Obesity Effects of Combined <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> Extract in High-Fat Diet-Induced Obese Male Mice Animals anti-obesity <i>Cornus officinalis</i> <i>Ribes fasciculatum</i> high-fat diet obese male mice |
| title | Anti-Obesity Effects of Combined <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> Extract in High-Fat Diet-Induced Obese Male Mice |
| title_full | Anti-Obesity Effects of Combined <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> Extract in High-Fat Diet-Induced Obese Male Mice |
| title_fullStr | Anti-Obesity Effects of Combined <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> Extract in High-Fat Diet-Induced Obese Male Mice |
| title_full_unstemmed | Anti-Obesity Effects of Combined <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> Extract in High-Fat Diet-Induced Obese Male Mice |
| title_short | Anti-Obesity Effects of Combined <i>Cornus officinalis</i> and <i>Ribes fasciculatum</i> Extract in High-Fat Diet-Induced Obese Male Mice |
| title_sort | anti obesity effects of combined i cornus officinalis i and i ribes fasciculatum i extract in high fat diet induced obese male mice |
| topic | anti-obesity <i>Cornus officinalis</i> <i>Ribes fasciculatum</i> high-fat diet obese male mice |
| url | https://www.mdpi.com/2076-2615/11/11/3187 |
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