Early detection of left ventricular diastolic dysfunction in Chagas' disease
<p>Abstract</p> <p>Background</p> <p>Chagas' disease may cause left ventricular diastolic dysfunction and its early detection in asymptomatic patients would allow to stratify the risk and to optimize medical treatment. The aim of this study is to investigate if tra...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2006-03-01
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| Series: | Cardiovascular Ultrasound |
| Online Access: | http://www.cardiovascularultrasound.com/content/4/1/18 |
| _version_ | 1818111659606016000 |
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| author | Prado Nilda G Morita Luis A Papantoniou Alonso Lax Jorge A Saccheri María C Cianciulli Tomás F Dorelle Adriana N Riarte Adelina R Prezioso Horacio A |
| author_facet | Prado Nilda G Morita Luis A Papantoniou Alonso Lax Jorge A Saccheri María C Cianciulli Tomás F Dorelle Adriana N Riarte Adelina R Prezioso Horacio A |
| author_sort | Prado Nilda G |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Chagas' disease may cause left ventricular diastolic dysfunction and its early detection in asymptomatic patients would allow to stratify the risk and to optimize medical treatment. The aim of this study is to investigate if transmitral Doppler flow can detect early abnormalities of the diastolic left ventricular function in patients during the indeterminate phase of Chagas' disease, in which the electrocardiogram (ECG), chest x-ray and 2-D echocardiogram (2D-echo) are normal.</p> <p>Methods</p> <p>a group of 54 patients with Chagas' disease was studied and compared to a control group of 27 subjects of similar age. All were assessed with an ECG, chest X-ray, 2-D echo, and transmitral Doppler flow.</p> <p>Results</p> <p>both groups had similar values in the 2D-echo. In patients with Chagas' disease, the transmitral Doppler showed a higher peak A velocity (control group: 0.44 m/sec, Chagas group: 0.55 m/sec, p = 0.001), a lower E/A ratio (control group: 1.45, Chagas group: 1.22, p < 0.05), and a lengthening of the deceleration time of early diastolic filling (control: 138.7 ± 26.8 msec, Chagas group: 167.9 ± 34.6 msec, p = 001), thus revealing an early disorder of the diastolic left ventricular function in patients with Chagas' disease.</p> <p>Conclusion</p> <p>in patients with Chagas' disease who are in the indeterminate phase, transmitral Doppler flow allowed to identify early abnormalities of the left ventricular diastolic function, which provide useful clinical information for prognostic stratification and treatment.</p> |
| first_indexed | 2024-12-11T03:06:34Z |
| format | Article |
| id | doaj.art-fb26e7626ea04a9aa263fa30dc0914e8 |
| institution | Directory Open Access Journal |
| issn | 1476-7120 |
| language | English |
| last_indexed | 2024-12-11T03:06:34Z |
| publishDate | 2006-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Ultrasound |
| spelling | doaj.art-fb26e7626ea04a9aa263fa30dc0914e82022-12-22T01:22:57ZengBMCCardiovascular Ultrasound1476-71202006-03-01411810.1186/1476-7120-4-18Early detection of left ventricular diastolic dysfunction in Chagas' diseasePrado Nilda GMorita Luis APapantoniou AlonsoLax Jorge ASaccheri María CCianciulli Tomás FDorelle Adriana NRiarte Adelina RPrezioso Horacio A<p>Abstract</p> <p>Background</p> <p>Chagas' disease may cause left ventricular diastolic dysfunction and its early detection in asymptomatic patients would allow to stratify the risk and to optimize medical treatment. The aim of this study is to investigate if transmitral Doppler flow can detect early abnormalities of the diastolic left ventricular function in patients during the indeterminate phase of Chagas' disease, in which the electrocardiogram (ECG), chest x-ray and 2-D echocardiogram (2D-echo) are normal.</p> <p>Methods</p> <p>a group of 54 patients with Chagas' disease was studied and compared to a control group of 27 subjects of similar age. All were assessed with an ECG, chest X-ray, 2-D echo, and transmitral Doppler flow.</p> <p>Results</p> <p>both groups had similar values in the 2D-echo. In patients with Chagas' disease, the transmitral Doppler showed a higher peak A velocity (control group: 0.44 m/sec, Chagas group: 0.55 m/sec, p = 0.001), a lower E/A ratio (control group: 1.45, Chagas group: 1.22, p < 0.05), and a lengthening of the deceleration time of early diastolic filling (control: 138.7 ± 26.8 msec, Chagas group: 167.9 ± 34.6 msec, p = 001), thus revealing an early disorder of the diastolic left ventricular function in patients with Chagas' disease.</p> <p>Conclusion</p> <p>in patients with Chagas' disease who are in the indeterminate phase, transmitral Doppler flow allowed to identify early abnormalities of the left ventricular diastolic function, which provide useful clinical information for prognostic stratification and treatment.</p>http://www.cardiovascularultrasound.com/content/4/1/18 |
| spellingShingle | Prado Nilda G Morita Luis A Papantoniou Alonso Lax Jorge A Saccheri María C Cianciulli Tomás F Dorelle Adriana N Riarte Adelina R Prezioso Horacio A Early detection of left ventricular diastolic dysfunction in Chagas' disease Cardiovascular Ultrasound |
| title | Early detection of left ventricular diastolic dysfunction in Chagas' disease |
| title_full | Early detection of left ventricular diastolic dysfunction in Chagas' disease |
| title_fullStr | Early detection of left ventricular diastolic dysfunction in Chagas' disease |
| title_full_unstemmed | Early detection of left ventricular diastolic dysfunction in Chagas' disease |
| title_short | Early detection of left ventricular diastolic dysfunction in Chagas' disease |
| title_sort | early detection of left ventricular diastolic dysfunction in chagas disease |
| url | http://www.cardiovascularultrasound.com/content/4/1/18 |
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