Effect of Age in Auditory Go/No-Go Tasks: A Magnetoencephalographic Study
Response inhibition is frequently examined using visual go/no-go tasks. Recently, the auditory go/no-go paradigm has been also applied to several clinical and aging populations. However, age-related changes in the neural underpinnings of auditory go/no-go tasks are yet to be elucidated. We used magn...
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| Format: | Article |
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MDPI AG
2020-09-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/10/10/667 |
| _version_ | 1797552660753154048 |
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| author | Mei-Yin Lin Chia-Hsiung Cheng |
| author_facet | Mei-Yin Lin Chia-Hsiung Cheng |
| author_sort | Mei-Yin Lin |
| collection | DOAJ |
| description | Response inhibition is frequently examined using visual go/no-go tasks. Recently, the auditory go/no-go paradigm has been also applied to several clinical and aging populations. However, age-related changes in the neural underpinnings of auditory go/no-go tasks are yet to be elucidated. We used magnetoencephalography combined with distributed source imaging methods to examine age-associated changes in neural responses to auditory no-go stimuli. Additionally, we compared the performance of high- and low-performing older adults to explore differences in cortical activation. Behavioral performance in terms of response inhibition was similar in younger and older adult groups. Relative to the younger adults, the older adults exhibited reduced cortical activation in the superior and middle temporal gyrus. However, we did not find any significant differences in cortical activation between the high- and low-performing older adults. Our results therefore support the hypothesis that inhibition is reduced during aging. The variation in cognitive performance among older adults confirms the need for further study on the underlying mechanisms of inhibition. |
| first_indexed | 2024-03-10T16:04:14Z |
| format | Article |
| id | doaj.art-fb27bceabfb540c2871a817fe7299411 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T16:04:14Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-fb27bceabfb540c2871a817fe72994112023-11-20T15:02:46ZengMDPI AGBrain Sciences2076-34252020-09-01101066710.3390/brainsci10100667Effect of Age in Auditory Go/No-Go Tasks: A Magnetoencephalographic StudyMei-Yin Lin0Chia-Hsiung Cheng1Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, Chang Gung University, Taoyuan 333, TaiwanDepartment of Occupational Therapy and Graduate Institute of Behavioral Sciences, Chang Gung University, Taoyuan 333, TaiwanResponse inhibition is frequently examined using visual go/no-go tasks. Recently, the auditory go/no-go paradigm has been also applied to several clinical and aging populations. However, age-related changes in the neural underpinnings of auditory go/no-go tasks are yet to be elucidated. We used magnetoencephalography combined with distributed source imaging methods to examine age-associated changes in neural responses to auditory no-go stimuli. Additionally, we compared the performance of high- and low-performing older adults to explore differences in cortical activation. Behavioral performance in terms of response inhibition was similar in younger and older adult groups. Relative to the younger adults, the older adults exhibited reduced cortical activation in the superior and middle temporal gyrus. However, we did not find any significant differences in cortical activation between the high- and low-performing older adults. Our results therefore support the hypothesis that inhibition is reduced during aging. The variation in cognitive performance among older adults confirms the need for further study on the underlying mechanisms of inhibition.https://www.mdpi.com/2076-3425/10/10/667inhibitionagingmagnetoencephalography (MEG)auditory go/no-go |
| spellingShingle | Mei-Yin Lin Chia-Hsiung Cheng Effect of Age in Auditory Go/No-Go Tasks: A Magnetoencephalographic Study Brain Sciences inhibition aging magnetoencephalography (MEG) auditory go/no-go |
| title | Effect of Age in Auditory Go/No-Go Tasks: A Magnetoencephalographic Study |
| title_full | Effect of Age in Auditory Go/No-Go Tasks: A Magnetoencephalographic Study |
| title_fullStr | Effect of Age in Auditory Go/No-Go Tasks: A Magnetoencephalographic Study |
| title_full_unstemmed | Effect of Age in Auditory Go/No-Go Tasks: A Magnetoencephalographic Study |
| title_short | Effect of Age in Auditory Go/No-Go Tasks: A Magnetoencephalographic Study |
| title_sort | effect of age in auditory go no go tasks a magnetoencephalographic study |
| topic | inhibition aging magnetoencephalography (MEG) auditory go/no-go |
| url | https://www.mdpi.com/2076-3425/10/10/667 |
| work_keys_str_mv | AT meiyinlin effectofageinauditorygonogotasksamagnetoencephalographicstudy AT chiahsiungcheng effectofageinauditorygonogotasksamagnetoencephalographicstudy |