Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity
The functional role of astrocyte calcium signaling in brain information processing was intensely debated in recent decades. This interest was motivated by high resolution imaging techniques showing highly developed structure of distal astrocyte processes. Another point was the evidence of bi-directi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2019.00294/full |
| _version_ | 1828417326298431488 |
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| author | Susan Yu. Gordleeva Anastasia V. Ermolaeva Innokentiy A. Kastalskiy Victor B. Kazantsev |
| author_facet | Susan Yu. Gordleeva Anastasia V. Ermolaeva Innokentiy A. Kastalskiy Victor B. Kazantsev |
| author_sort | Susan Yu. Gordleeva |
| collection | DOAJ |
| description | The functional role of astrocyte calcium signaling in brain information processing was intensely debated in recent decades. This interest was motivated by high resolution imaging techniques showing highly developed structure of distal astrocyte processes. Another point was the evidence of bi-directional astrocytic regulation of neuronal activity. To analyze the effects of interplay of calcium signals in processes and in soma mediating correlations between local signals and the cell-level response of the astrocyte we proposed spatially extended model of the astrocyte calcium dynamics. Specifically, we investigated how spatiotemporal properties of Ca2+ dynamics in spatially extended astrocyte model can coordinate (e.g., synchronize) networks of neurons and synapses. |
| first_indexed | 2024-12-10T14:18:29Z |
| format | Article |
| id | doaj.art-fb291d62cb3c465ca30ef12b59bb1325 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-10T14:18:29Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-fb291d62cb3c465ca30ef12b59bb13252022-12-22T01:45:17ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2019-04-011010.3389/fphys.2019.00294428089Astrocyte as Spatiotemporal Integrating Detector of Neuronal ActivitySusan Yu. GordleevaAnastasia V. ErmolaevaInnokentiy A. KastalskiyVictor B. KazantsevThe functional role of astrocyte calcium signaling in brain information processing was intensely debated in recent decades. This interest was motivated by high resolution imaging techniques showing highly developed structure of distal astrocyte processes. Another point was the evidence of bi-directional astrocytic regulation of neuronal activity. To analyze the effects of interplay of calcium signals in processes and in soma mediating correlations between local signals and the cell-level response of the astrocyte we proposed spatially extended model of the astrocyte calcium dynamics. Specifically, we investigated how spatiotemporal properties of Ca2+ dynamics in spatially extended astrocyte model can coordinate (e.g., synchronize) networks of neurons and synapses.https://www.frontiersin.org/article/10.3389/fphys.2019.00294/fullastrocytesynaptic transmissionneuron–astrocyte interactionneuron–astrocyte networkcalcium |
| spellingShingle | Susan Yu. Gordleeva Anastasia V. Ermolaeva Innokentiy A. Kastalskiy Victor B. Kazantsev Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity Frontiers in Physiology astrocyte synaptic transmission neuron–astrocyte interaction neuron–astrocyte network calcium |
| title | Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity |
| title_full | Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity |
| title_fullStr | Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity |
| title_full_unstemmed | Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity |
| title_short | Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity |
| title_sort | astrocyte as spatiotemporal integrating detector of neuronal activity |
| topic | astrocyte synaptic transmission neuron–astrocyte interaction neuron–astrocyte network calcium |
| url | https://www.frontiersin.org/article/10.3389/fphys.2019.00294/full |
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