Exploring the contribution of pro-inflammatory cytokines to impaired wound healing in diabetes
BackgroundImpaired wound healing is the most common and significant complication of Diabetes. While most other complications of Diabetes have better treatment options, diabetic wounds remain a burden as they can cause pain and suffering in patients. Wound closure and repair are orchestrated by a seq...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1216321/full |
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| author | S. Nirenjen J. Narayanan T. Tamilanban Vetriselvan Subramaniyan Vetriselvan Subramaniyan V. Chitra Neeraj Kumar Fuloria Ling Shing Wong Gobinath Ramachawolran Mahendran Sekar Gaurav Gupta Gaurav Gupta Shivkanya Fuloria Suresh V. Chinni Suresh V. Chinni Siddharthan Selvaraj |
| author_facet | S. Nirenjen J. Narayanan T. Tamilanban Vetriselvan Subramaniyan Vetriselvan Subramaniyan V. Chitra Neeraj Kumar Fuloria Ling Shing Wong Gobinath Ramachawolran Mahendran Sekar Gaurav Gupta Gaurav Gupta Shivkanya Fuloria Suresh V. Chinni Suresh V. Chinni Siddharthan Selvaraj |
| author_sort | S. Nirenjen |
| collection | DOAJ |
| description | BackgroundImpaired wound healing is the most common and significant complication of Diabetes. While most other complications of Diabetes have better treatment options, diabetic wounds remain a burden as they can cause pain and suffering in patients. Wound closure and repair are orchestrated by a sequence of events aided by the release of pro-inflammatory cytokines, which are dysregulated in cases of Diabetes, making the wound environment unfavorable for healing and delaying the wound healing processes. This concise review provides an overview of the dysregulation of pro-inflammatory cytokines and offers insights into better therapeutic outcomes.Purpose of reviewAlthough many therapeutic approaches have been lined up nowadays to treat Diabetes, there are no proper treatment modalities proposed yet in treating diabetic wounds due to the lack of understanding about the role of inflammatory mediators, especially Pro-inflammatory mediators- Cytokines, in the process of Wound healing which we mainly focus on this review.Recent findingsAlthough complications of Diabetes mellitus are most reported after years of diagnosis, the most severe critical complication is impaired Wound Healing among Diabetes patients. Even though Trauma, Peripheral Artery Disease, and Peripheral Neuropathy are the leading triggering factors for the development of ulcerations, the most significant issue contributing to the development of complicated cutaneous wounds is wound healing impairment. It may even end up with amputation. Newer therapeutic approaches such as incorporating the additives in the present dressing materials, which include antimicrobial molecules and immunomodulatory cytokines is of better therapeutic value.SummaryThe adoption of these technologies and the establishment of novel therapeutic interventions is difficult since there is a gap in terms of a complete understanding of the pathophysiological mechanisms at the cellular and molecular level and the lack of data in terms of the assessment of safety and bioavailability differences in the individuals’ patients. The target-specific pro-inflammatory cytokines-based therapies, either by upregulation or downregulation of them, will be helpful in the wound healing process and thereby enhances the Quality of life in patients, which is the goal of drug therapy. |
| first_indexed | 2024-03-12T21:31:08Z |
| format | Article |
| id | doaj.art-fb2a0a105dbd4b3ab83d9af1c15d2d3a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-12T21:31:08Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-fb2a0a105dbd4b3ab83d9af1c15d2d3a2023-07-27T21:15:43ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-07-011410.3389/fimmu.2023.12163211216321Exploring the contribution of pro-inflammatory cytokines to impaired wound healing in diabetesS. Nirenjen0J. Narayanan1T. Tamilanban2Vetriselvan Subramaniyan3Vetriselvan Subramaniyan4V. Chitra5Neeraj Kumar Fuloria6Ling Shing Wong7Gobinath Ramachawolran8Mahendran Sekar9Gaurav Gupta10Gaurav Gupta11Shivkanya Fuloria12Suresh V. Chinni13Suresh V. Chinni14Siddharthan Selvaraj15Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, IndiaDepartment of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, IndiaDepartment of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, IndiaJeffrey Cheah School of Medicine and Health Sciences, Monash University, Jalan Lagoon Selatan, Bandar Sunway, Petaling Jaya, Selangor, MalaysiaCenter for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, IndiaDepartment of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, IndiaFaculty of Pharmacy, AIMST University, Bedong, Kedah, MalaysiaFaculty of Health and Life Sciences, INTI International University, Nilai, MalaysiaDepartment of Foundation, RCSI & UCD Malaysia Campus, Jalan Sepoy Lines, Georgetown, Pulau Pinang, MalaysiaSchool of Pharmacy, Monash University Malaysia, Subang Jaya, Selangor, MalaysiaSchool of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Mahal Road, Jaipur, IndiaUttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, IndiaFaculty of Pharmacy, AIMST University, Bedong, Kedah, Malaysia0Department of Biochemistry, Faculty of Medicine, Bioscience, and Nursing, MAHSA University, Jenjarom, Selangor, Malaysia1Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India2Faculty of Dentistry, AIMST University, Semeling, Kedah, MalaysiaBackgroundImpaired wound healing is the most common and significant complication of Diabetes. While most other complications of Diabetes have better treatment options, diabetic wounds remain a burden as they can cause pain and suffering in patients. Wound closure and repair are orchestrated by a sequence of events aided by the release of pro-inflammatory cytokines, which are dysregulated in cases of Diabetes, making the wound environment unfavorable for healing and delaying the wound healing processes. This concise review provides an overview of the dysregulation of pro-inflammatory cytokines and offers insights into better therapeutic outcomes.Purpose of reviewAlthough many therapeutic approaches have been lined up nowadays to treat Diabetes, there are no proper treatment modalities proposed yet in treating diabetic wounds due to the lack of understanding about the role of inflammatory mediators, especially Pro-inflammatory mediators- Cytokines, in the process of Wound healing which we mainly focus on this review.Recent findingsAlthough complications of Diabetes mellitus are most reported after years of diagnosis, the most severe critical complication is impaired Wound Healing among Diabetes patients. Even though Trauma, Peripheral Artery Disease, and Peripheral Neuropathy are the leading triggering factors for the development of ulcerations, the most significant issue contributing to the development of complicated cutaneous wounds is wound healing impairment. It may even end up with amputation. Newer therapeutic approaches such as incorporating the additives in the present dressing materials, which include antimicrobial molecules and immunomodulatory cytokines is of better therapeutic value.SummaryThe adoption of these technologies and the establishment of novel therapeutic interventions is difficult since there is a gap in terms of a complete understanding of the pathophysiological mechanisms at the cellular and molecular level and the lack of data in terms of the assessment of safety and bioavailability differences in the individuals’ patients. The target-specific pro-inflammatory cytokines-based therapies, either by upregulation or downregulation of them, will be helpful in the wound healing process and thereby enhances the Quality of life in patients, which is the goal of drug therapy.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1216321/fullwound healingpro-inflammatorydiabetes mellituscytokinestherapeutic approach |
| spellingShingle | S. Nirenjen J. Narayanan T. Tamilanban Vetriselvan Subramaniyan Vetriselvan Subramaniyan V. Chitra Neeraj Kumar Fuloria Ling Shing Wong Gobinath Ramachawolran Mahendran Sekar Gaurav Gupta Gaurav Gupta Shivkanya Fuloria Suresh V. Chinni Suresh V. Chinni Siddharthan Selvaraj Exploring the contribution of pro-inflammatory cytokines to impaired wound healing in diabetes Frontiers in Immunology wound healing pro-inflammatory diabetes mellitus cytokines therapeutic approach |
| title | Exploring the contribution of pro-inflammatory cytokines to impaired wound healing in diabetes |
| title_full | Exploring the contribution of pro-inflammatory cytokines to impaired wound healing in diabetes |
| title_fullStr | Exploring the contribution of pro-inflammatory cytokines to impaired wound healing in diabetes |
| title_full_unstemmed | Exploring the contribution of pro-inflammatory cytokines to impaired wound healing in diabetes |
| title_short | Exploring the contribution of pro-inflammatory cytokines to impaired wound healing in diabetes |
| title_sort | exploring the contribution of pro inflammatory cytokines to impaired wound healing in diabetes |
| topic | wound healing pro-inflammatory diabetes mellitus cytokines therapeutic approach |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1216321/full |
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