Guaraná (Paullinia cupana) for chemotherapy-related fatigue
Objective: To evaluate the effect of guarana in patients with solid tumors starting on chemotherapy, insofar as chemotherapy-induced fatigue and depressive symptoms are concerned. Methods: This is a double-blind, cross-over trial in which chemotherapy naive patients were randomized to take either gu...
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| Format: | Article |
| Language: | English |
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
2008-09-01
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| Series: | Einstein (São Paulo) |
| Subjects: | |
| Online Access: | http://www.einstein.br/revista/arquivos/PDF/846-Einsteinv6n2p195-9.pdf |
| _version_ | 1818661683034324992 |
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| author | Auro Del Giglio Rachel Riechelmann Thaís Zampa de Campos Trindade Vinicius de Oliveira Lucas Scatigno Saad Flávia Delgado Martins Ângelo Bezerra de Souza Fêde Damila Cristina Trufelli Vanessa da Costa Miranda |
| author_facet | Auro Del Giglio Rachel Riechelmann Thaís Zampa de Campos Trindade Vinicius de Oliveira Lucas Scatigno Saad Flávia Delgado Martins Ângelo Bezerra de Souza Fêde Damila Cristina Trufelli Vanessa da Costa Miranda |
| author_sort | Auro Del Giglio |
| collection | DOAJ |
| description | Objective: To evaluate the effect of guarana in patients with solid tumors starting on chemotherapy, insofar as chemotherapy-induced fatigue and depressive symptoms are concerned. Methods: This is a double-blind, cross-over trial in which chemotherapy naive patients were randomized to take either guarana 75 mg or placebo tablets during the first cycle of chemotherapy and then switched to the alternative for the second cycle. We evaluated fatigue and depressive symptoms using Portuguese-validated instruments: Chalder Fatigue Scale, Brief Fatigue Inventory, and Beck Depression Inventory. Rresults: From January to June 2007, 38 patients were recruited and 12 dropped out before outcome assessments. We did not observe any statistically significant differences between or within groups in fatigue or depression scores among the 26 evaluable patients. After the end of the still blinded second cycle, nine patients voiced their preference for guarana and 17 for placebo (p = 0.059). Cconclusions: In this pilot study, guarana was not effective to prevent chemotherapy-related fatigue and/or depressive symptoms. |
| first_indexed | 2024-12-17T04:48:57Z |
| format | Article |
| id | doaj.art-fb2b97a701aa461f8b1d8716d8e5ad68 |
| institution | Directory Open Access Journal |
| issn | 1679-4508 |
| language | English |
| last_indexed | 2024-12-17T04:48:57Z |
| publishDate | 2008-09-01 |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-fb2b97a701aa461f8b1d8716d8e5ad682022-12-21T22:02:58ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)1679-45082008-09-0162195199Guaraná (Paullinia cupana) for chemotherapy-related fatigueAuro Del GiglioRachel RiechelmannThaís Zampa de Campos TrindadeVinicius de OliveiraLucas Scatigno SaadFlávia Delgado MartinsÂngelo Bezerra de Souza FêdeDamila Cristina TrufelliVanessa da Costa MirandaObjective: To evaluate the effect of guarana in patients with solid tumors starting on chemotherapy, insofar as chemotherapy-induced fatigue and depressive symptoms are concerned. Methods: This is a double-blind, cross-over trial in which chemotherapy naive patients were randomized to take either guarana 75 mg or placebo tablets during the first cycle of chemotherapy and then switched to the alternative for the second cycle. We evaluated fatigue and depressive symptoms using Portuguese-validated instruments: Chalder Fatigue Scale, Brief Fatigue Inventory, and Beck Depression Inventory. Rresults: From January to June 2007, 38 patients were recruited and 12 dropped out before outcome assessments. We did not observe any statistically significant differences between or within groups in fatigue or depression scores among the 26 evaluable patients. After the end of the still blinded second cycle, nine patients voiced their preference for guarana and 17 for placebo (p = 0.059). Cconclusions: In this pilot study, guarana was not effective to prevent chemotherapy-related fatigue and/or depressive symptoms.http://www.einstein.br/revista/arquivos/PDF/846-Einsteinv6n2p195-9.pdfPaulliniaFatigue/etiologyDepression/etiologyNeoplasms/complicationsNeoplasms/psychologyNeoplasms/drug therapyDrug therapy |
| spellingShingle | Auro Del Giglio Rachel Riechelmann Thaís Zampa de Campos Trindade Vinicius de Oliveira Lucas Scatigno Saad Flávia Delgado Martins Ângelo Bezerra de Souza Fêde Damila Cristina Trufelli Vanessa da Costa Miranda Guaraná (Paullinia cupana) for chemotherapy-related fatigue Einstein (São Paulo) Paullinia Fatigue/etiology Depression/etiology Neoplasms/complications Neoplasms/psychology Neoplasms/drug therapy Drug therapy |
| title | Guaraná (Paullinia cupana) for chemotherapy-related fatigue |
| title_full | Guaraná (Paullinia cupana) for chemotherapy-related fatigue |
| title_fullStr | Guaraná (Paullinia cupana) for chemotherapy-related fatigue |
| title_full_unstemmed | Guaraná (Paullinia cupana) for chemotherapy-related fatigue |
| title_short | Guaraná (Paullinia cupana) for chemotherapy-related fatigue |
| title_sort | guarana paullinia cupana for chemotherapy related fatigue |
| topic | Paullinia Fatigue/etiology Depression/etiology Neoplasms/complications Neoplasms/psychology Neoplasms/drug therapy Drug therapy |
| url | http://www.einstein.br/revista/arquivos/PDF/846-Einsteinv6n2p195-9.pdf |
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