Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase

Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase

Many important cellular membrane fission reactions are driven by ESCRT pathways, which culminate in disassembly of ESCRT-III polymers by the AAA ATPase Vps4. We report a 4.3 Å resolution cryo-EM structure of the active Vps4 hexamer with its cofactor Vta1, ADP·BeFx, and an ESCRT-III substrate peptide...

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Bibliographic Details
Main Authors: Nicole Monroe, Han Han, Peter S Shen, Wesley I Sundquist, Christopher P Hill
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-04-01
Series:eLife
Subjects:
AAA ATPases
ESCRT pathway
Cryo-EM
Online Access:https://elifesciences.org/articles/24487

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