Stereoselective Synthesis of Euscapholide and Tetraketide via Prins Cyclisation and Ring-Closing Metathesis

Stereoselective Synthesis of Euscapholide and Tetraketide via Prins Cyclisation and Ring-Closing Metathesis

A concise and diastereoselective total synthesis of tetraketide and euscapholide is described in ten steps in 10.6% overall yield from acetaldehyde and (S)-pent-4-ene-1,2-diol. Jacobsen hydrolytic kinetic resolution, Prins cyclization, ring-closing metathesis and oxa-Michael addition reactions are...

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Bibliographic Details
Main Authors:	Dhanraj O. Biradar, Yogesh D. Mane, Basi V. Subba Reddy
Format:	Article
Language:	English
Published:	Georg Thieme Verlag KG 2022-11-01
Series:	SynOpen
Subjects:	prins cyclization euscapholide tetraketide ring-closing metathesis
Online Access:	http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1751381

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