Spin-echo and diffusion-weighted MRI in differentiation between progressive massive fibrosis and lung cancer
PURPOSEWe aimed to investigate the value of magnetic resonance imaging (MRI)-based parameters in differentiating between progressive massive fibrosis (PMF) and lung cancer.METHODSThis retrospective study included 60 male patients (mean age, 67.0±9.0 years) with a history of more than 10 years workin...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2021-07-01
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| Series: | Diagnostic and Interventional Radiology |
| Online Access: |
http://www.dirjournal.org/archives/archive-detail/article-preview/spin-echo-and-diffusion-weighted-mr-in-differentia/54196
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| _version_ | 1797691397410652160 |
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| author | Serkan Guneyli Meltem Tor Hur Hassoy Murat Serhat Aygun Emre Altinmakas Susamber Dik Altintas Recep Savas |
| author_facet | Serkan Guneyli Meltem Tor Hur Hassoy Murat Serhat Aygun Emre Altinmakas Susamber Dik Altintas Recep Savas |
| author_sort | Serkan Guneyli |
| collection | DOAJ |
| description | PURPOSEWe aimed to investigate the value of magnetic resonance imaging (MRI)-based parameters in differentiating between progressive massive fibrosis (PMF) and lung cancer.METHODSThis retrospective study included 60 male patients (mean age, 67.0±9.0 years) with a history of more than 10 years working in underground coal mines who underwent 1.5 T MRI of thorax due to a lung nodule/mass suspicious for lung cancer on computed tomography. Thirty patients had PMF, and the remaining ones had lung cancer diagnosed histopathologically. The sequences were as follows: coronal single-shot turbo spin echo (SSH-TSE), axial T1- and T2-weighted spin-echo (SE), balanced turbo field echo, T1-weighted high-resolution isotropic volume excitation, free-breathing and respiratory triggered diffusion-weighted imaging (DWI). The patients’ demographics, lesion sizes, and MRI‐derived parameters were compared between the patients with PMF and lung cancer.RESULTSApparent diffusion coefficient (ADC) values of DWI and respiratory triggered DWI, signal intensities on T1-weighted SE, T2-weighted SE, and SSH-TSE imaging were found to be significantly different between the groups (p < 0.001, for all comparisons). Median ADC values of free-breathing DWI in patients with PMF and cancer were 1.25 (0.93–2.60) and 0.76 (0.53–1.00) (× 10-3 mm2/s), respectively. Most PMF lesions were predominantly iso- or hypointense on T1-weighted SE, T2-weighted SE, and SSH-TSE, while most malignant ones predominantly showed high signal intensity on these sequences.CONCLUSIONMRI study including SE imaging, specially T1-weighted SE imaging and ADC values of DWI can help to distinguish PMF from lung cancer. |
| first_indexed | 2024-03-12T02:12:44Z |
| format | Article |
| id | doaj.art-fb2ffedd9ebe4c658f73a2297b928d40 |
| institution | Directory Open Access Journal |
| issn | 1305-3825 1305-3612 |
| language | English |
| last_indexed | 2024-03-12T02:12:44Z |
| publishDate | 2021-07-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Diagnostic and Interventional Radiology |
| spelling | doaj.art-fb2ffedd9ebe4c658f73a2297b928d402023-09-06T12:19:28ZengGalenos Publishing HouseDiagnostic and Interventional Radiology1305-38251305-36122021-07-0127446947510.5152/dir.2021.2034413049054Spin-echo and diffusion-weighted MRI in differentiation between progressive massive fibrosis and lung cancerSerkan Guneyli0Meltem Tor1Hur Hassoy2Murat Serhat Aygun3Emre Altinmakas4Susamber Dik Altintas5Recep Savas6 Department of Radiology, Koc University, Istanbul, Turkey Department of Pulmonology, Bulent Ecevit University, Zonguldak, Turkey Department of Public Health, Ege University, Izmir, Turkey Department of Radiology, Koc University, Istanbul, Turkey Department of Radiology, Koc University, Istanbul, Turkey Department of Pulmonology, Bulent Ecevit University, Zonguldak, Turkey Department of Radiology, Ege University, Izmir, Turkey PURPOSEWe aimed to investigate the value of magnetic resonance imaging (MRI)-based parameters in differentiating between progressive massive fibrosis (PMF) and lung cancer.METHODSThis retrospective study included 60 male patients (mean age, 67.0±9.0 years) with a history of more than 10 years working in underground coal mines who underwent 1.5 T MRI of thorax due to a lung nodule/mass suspicious for lung cancer on computed tomography. Thirty patients had PMF, and the remaining ones had lung cancer diagnosed histopathologically. The sequences were as follows: coronal single-shot turbo spin echo (SSH-TSE), axial T1- and T2-weighted spin-echo (SE), balanced turbo field echo, T1-weighted high-resolution isotropic volume excitation, free-breathing and respiratory triggered diffusion-weighted imaging (DWI). The patients’ demographics, lesion sizes, and MRI‐derived parameters were compared between the patients with PMF and lung cancer.RESULTSApparent diffusion coefficient (ADC) values of DWI and respiratory triggered DWI, signal intensities on T1-weighted SE, T2-weighted SE, and SSH-TSE imaging were found to be significantly different between the groups (p < 0.001, for all comparisons). Median ADC values of free-breathing DWI in patients with PMF and cancer were 1.25 (0.93–2.60) and 0.76 (0.53–1.00) (× 10-3 mm2/s), respectively. Most PMF lesions were predominantly iso- or hypointense on T1-weighted SE, T2-weighted SE, and SSH-TSE, while most malignant ones predominantly showed high signal intensity on these sequences.CONCLUSIONMRI study including SE imaging, specially T1-weighted SE imaging and ADC values of DWI can help to distinguish PMF from lung cancer. http://www.dirjournal.org/archives/archive-detail/article-preview/spin-echo-and-diffusion-weighted-mr-in-differentia/54196 |
| spellingShingle | Serkan Guneyli Meltem Tor Hur Hassoy Murat Serhat Aygun Emre Altinmakas Susamber Dik Altintas Recep Savas Spin-echo and diffusion-weighted MRI in differentiation between progressive massive fibrosis and lung cancer Diagnostic and Interventional Radiology |
| title | Spin-echo and diffusion-weighted MRI in differentiation between progressive massive fibrosis and lung cancer |
| title_full | Spin-echo and diffusion-weighted MRI in differentiation between progressive massive fibrosis and lung cancer |
| title_fullStr | Spin-echo and diffusion-weighted MRI in differentiation between progressive massive fibrosis and lung cancer |
| title_full_unstemmed | Spin-echo and diffusion-weighted MRI in differentiation between progressive massive fibrosis and lung cancer |
| title_short | Spin-echo and diffusion-weighted MRI in differentiation between progressive massive fibrosis and lung cancer |
| title_sort | spin echo and diffusion weighted mri in differentiation between progressive massive fibrosis and lung cancer |
| url |
http://www.dirjournal.org/archives/archive-detail/article-preview/spin-echo-and-diffusion-weighted-mr-in-differentia/54196
|
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