Oxymatrine ameliorates experimental autoimmune encephalomyelitis by rebalancing the homeostasis of gut microbiota and reducing blood-brain barrier disruption

Oxymatrine ameliorates experimental autoimmune encephalomyelitis by rebalancing the homeostasis of gut microbiota and reducing blood-brain barrier disruption

BackgroundIncreasing evidence suggests that gut dysbiosis can directly or indirectly affect the immune system through the brain-gut axis and play a role in the occurrence and development of Multiple sclerosis (MS). Oxymatrine (OMAT) has been shown to ameliorate the symptoms of MS in the classical ex...

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Bibliographic Details
Main Authors:	Ming-Liang Zhang, Wei-Xia Li, Xiao-Yan Wang, Ya-Li Wu, Xiao-Fei Chen, Hui Zhang, Liu-Qing Yang, Cheng-Zhao Wu, Shu-Qi Zhang, Yu-Long Chen, Ke-Ran Feng, Bin Wang, Lu Niu, De-Xin Kong, Jin-Fa Tang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-01-01
Series:	Frontiers in Cellular and Infection Microbiology
Subjects:	oxymatrine experimental autoimmune encephalomyelitis gut microbiota brain-gut axis short-chain fatty acids
Online Access:	https://www.frontiersin.org/articles/10.3389/fcimb.2022.1095053/full

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