Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence
Experimenter-delivered alcohol decreases adult hippocampal neurogenesis and hippocampal-dependent learning and memory. The present study used clinically relevant rodent models of nondependent limited access alcohol self-administration and excessive drinking during alcohol dependence (alcohol self-ad...
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| Format: | Article |
| Language: | English |
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Elsevier
2009-10-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996109001247 |
| _version_ | 1830193345630044160 |
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| author | Heather N. Richardson Stephanie H. Chan Elena F. Crawford Youn Kyung Lee Cindy K. Funk George F. Koob Chitra D. Mandyam |
| author_facet | Heather N. Richardson Stephanie H. Chan Elena F. Crawford Youn Kyung Lee Cindy K. Funk George F. Koob Chitra D. Mandyam |
| author_sort | Heather N. Richardson |
| collection | DOAJ |
| description | Experimenter-delivered alcohol decreases adult hippocampal neurogenesis and hippocampal-dependent learning and memory. The present study used clinically relevant rodent models of nondependent limited access alcohol self-administration and excessive drinking during alcohol dependence (alcohol self-administration followed by intermittent exposure to alcohol vapors over several weeks) to compare alcohol-induced effects on cortical gliogenesis and hippocampal neurogenesis. Alcohol dependence, but not nondependent drinking, reduced proliferation and survival in the medial prefrontal cortex (mPFC). Apoptosis was reduced in both alcohol groups within the mPFC, which may reflect an initiation of a reparative environment following alcohol exposure as decreased proliferation was abolished after prolonged dependence. Reduced proliferation, differentiation, and neurogenesis were observed in the hippocampus of both alcohol groups, and prolonged dependence worsened the effects. Increased hippocampal apoptosis and neuronal degeneration following alcohol exposure suggest a loss in neuronal turnover and indicate that the hippocampal neurogenic niche is highly vulnerable to alcohol. |
| first_indexed | 2024-12-18T00:11:33Z |
| format | Article |
| id | doaj.art-fb300a5f25824f819c134de47bd608d1 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-18T00:11:33Z |
| publishDate | 2009-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-fb300a5f25824f819c134de47bd608d12022-12-21T21:27:40ZengElsevierNeurobiology of Disease1095-953X2009-10-01361110Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependenceHeather N. Richardson0Stephanie H. Chan1Elena F. Crawford2Youn Kyung Lee3Cindy K. Funk4George F. Koob5Chitra D. Mandyam6Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2400, La Jolla, CA 92037, USACommittee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2400, La Jolla, CA 92037, USACommittee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2400, La Jolla, CA 92037, USACommittee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2400, La Jolla, CA 92037, USACommittee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2400, La Jolla, CA 92037, USACommittee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2400, La Jolla, CA 92037, USACorresponding author. Fax: +1 858 784 8851.; Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2400, La Jolla, CA 92037, USAExperimenter-delivered alcohol decreases adult hippocampal neurogenesis and hippocampal-dependent learning and memory. The present study used clinically relevant rodent models of nondependent limited access alcohol self-administration and excessive drinking during alcohol dependence (alcohol self-administration followed by intermittent exposure to alcohol vapors over several weeks) to compare alcohol-induced effects on cortical gliogenesis and hippocampal neurogenesis. Alcohol dependence, but not nondependent drinking, reduced proliferation and survival in the medial prefrontal cortex (mPFC). Apoptosis was reduced in both alcohol groups within the mPFC, which may reflect an initiation of a reparative environment following alcohol exposure as decreased proliferation was abolished after prolonged dependence. Reduced proliferation, differentiation, and neurogenesis were observed in the hippocampus of both alcohol groups, and prolonged dependence worsened the effects. Increased hippocampal apoptosis and neuronal degeneration following alcohol exposure suggest a loss in neuronal turnover and indicate that the hippocampal neurogenic niche is highly vulnerable to alcohol.http://www.sciencedirect.com/science/article/pii/S0969996109001247Prefrontal cortexSubgranular zoneSelf-administrationAlcohol vaporKi-67Bromodeoxyuridine |
| spellingShingle | Heather N. Richardson Stephanie H. Chan Elena F. Crawford Youn Kyung Lee Cindy K. Funk George F. Koob Chitra D. Mandyam Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence Neurobiology of Disease Prefrontal cortex Subgranular zone Self-administration Alcohol vapor Ki-67 Bromodeoxyuridine |
| title | Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence |
| title_full | Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence |
| title_fullStr | Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence |
| title_full_unstemmed | Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence |
| title_short | Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence |
| title_sort | permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence |
| topic | Prefrontal cortex Subgranular zone Self-administration Alcohol vapor Ki-67 Bromodeoxyuridine |
| url | http://www.sciencedirect.com/science/article/pii/S0969996109001247 |
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