Selected Biomarkers of Inflammation in Patients with Head and Neck Cancer Depending on the Tumor Location
Head and neck cancers (HNCs) are a group of neoplasms located in the area of the oral cavity, pharynx, larynx, paranasal sinuses, nasal cavity and salivary glands. HNCs are the sixth most common type of cancer in the Europe population. As in other neoplastic diseases, chronic inflammation occurs in...
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MDPI AG
2022-11-01
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| Series: | Medical Sciences Forum |
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| Online Access: | https://www.mdpi.com/2673-9992/14/1/29 |
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| author | Jarosław Nuszkiewicz Marlena Budek Jolanta Czuczejko Karolina Szewczyk-Golec |
| author_facet | Jarosław Nuszkiewicz Marlena Budek Jolanta Czuczejko Karolina Szewczyk-Golec |
| author_sort | Jarosław Nuszkiewicz |
| collection | DOAJ |
| description | Head and neck cancers (HNCs) are a group of neoplasms located in the area of the oral cavity, pharynx, larynx, paranasal sinuses, nasal cavity and salivary glands. HNCs are the sixth most common type of cancer in the Europe population. As in other neoplastic diseases, chronic inflammation occurs in HNC, affecting not only the location of the tumor, but also distant healthy tissues. In patients with HNC, changes in the levels of pro- and anti-inflammatory cytokines are observed. The aim of this study was to assess the level of interleukin 3 (IL-3), IL-4, IL-13, monocyte chemoattractant protein 1 (MCP-1) and MCP-2 in patients with HNC depending on the tumor localization. The study group consisted of 40 HNC patients divided into two groups according to the localization of the tumor: 20 subjects with cancer located in the area of the oral cavity (OC) and 20 subjects with cancer located in the area of pharynx and larynx (PL). Blood serum samples were used to perform the analyses. A value of <i>p</i> < 0.05 was considered as statistically significant. In the PL group, statistically significant higher concentrations of IL-13 and MCP-1 were observed. The level of IL-13 in the OC group was 3.99 ± 0.50 pg/mL, while in the PL group it was 5.79 ± 0.64 pg/mL. The MCP-1 concentration was 68.15 ± 7.06 pg/mL and 109.01 ± 10.76 pg/mL, respectively. There were no statistically significant differences in the levels of IL-3, IL-4 and MCP-2. This experiment indicates that IL-13 and MCP-1 may be potential biomarkers differentiating tumor localization in patients with HNC. |
| first_indexed | 2024-03-11T06:06:56Z |
| format | Article |
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| issn | 2673-9992 |
| language | English |
| last_indexed | 2024-03-11T06:06:56Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medical Sciences Forum |
| spelling | doaj.art-fb3051815fe94985b4fcdba7eb0f62702023-11-17T12:57:08ZengMDPI AGMedical Sciences Forum2673-99922022-11-011412910.3390/ECMC2022-13297Selected Biomarkers of Inflammation in Patients with Head and Neck Cancer Depending on the Tumor LocationJarosław Nuszkiewicz0Marlena Budek1Jolanta Czuczejko2Karolina Szewczyk-Golec3Department of Medical Biology and Biochemistry, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 24 Karłowicza St., 85-092 Bydgoszcz, PolandDepartment of Medical Biology and Biochemistry, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 24 Karłowicza St., 85-092 Bydgoszcz, PolandDepartment of Psychiatry, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 9 M. Curie Skłodowskiej St., 85-094 Bydgoszcz, PolandDepartment of Medical Biology and Biochemistry, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 24 Karłowicza St., 85-092 Bydgoszcz, PolandHead and neck cancers (HNCs) are a group of neoplasms located in the area of the oral cavity, pharynx, larynx, paranasal sinuses, nasal cavity and salivary glands. HNCs are the sixth most common type of cancer in the Europe population. As in other neoplastic diseases, chronic inflammation occurs in HNC, affecting not only the location of the tumor, but also distant healthy tissues. In patients with HNC, changes in the levels of pro- and anti-inflammatory cytokines are observed. The aim of this study was to assess the level of interleukin 3 (IL-3), IL-4, IL-13, monocyte chemoattractant protein 1 (MCP-1) and MCP-2 in patients with HNC depending on the tumor localization. The study group consisted of 40 HNC patients divided into two groups according to the localization of the tumor: 20 subjects with cancer located in the area of the oral cavity (OC) and 20 subjects with cancer located in the area of pharynx and larynx (PL). Blood serum samples were used to perform the analyses. A value of <i>p</i> < 0.05 was considered as statistically significant. In the PL group, statistically significant higher concentrations of IL-13 and MCP-1 were observed. The level of IL-13 in the OC group was 3.99 ± 0.50 pg/mL, while in the PL group it was 5.79 ± 0.64 pg/mL. The MCP-1 concentration was 68.15 ± 7.06 pg/mL and 109.01 ± 10.76 pg/mL, respectively. There were no statistically significant differences in the levels of IL-3, IL-4 and MCP-2. This experiment indicates that IL-13 and MCP-1 may be potential biomarkers differentiating tumor localization in patients with HNC.https://www.mdpi.com/2673-9992/14/1/29biomarkerscytokineshead and neck cancerinflammation |
| spellingShingle | Jarosław Nuszkiewicz Marlena Budek Jolanta Czuczejko Karolina Szewczyk-Golec Selected Biomarkers of Inflammation in Patients with Head and Neck Cancer Depending on the Tumor Location Medical Sciences Forum biomarkers cytokines head and neck cancer inflammation |
| title | Selected Biomarkers of Inflammation in Patients with Head and Neck Cancer Depending on the Tumor Location |
| title_full | Selected Biomarkers of Inflammation in Patients with Head and Neck Cancer Depending on the Tumor Location |
| title_fullStr | Selected Biomarkers of Inflammation in Patients with Head and Neck Cancer Depending on the Tumor Location |
| title_full_unstemmed | Selected Biomarkers of Inflammation in Patients with Head and Neck Cancer Depending on the Tumor Location |
| title_short | Selected Biomarkers of Inflammation in Patients with Head and Neck Cancer Depending on the Tumor Location |
| title_sort | selected biomarkers of inflammation in patients with head and neck cancer depending on the tumor location |
| topic | biomarkers cytokines head and neck cancer inflammation |
| url | https://www.mdpi.com/2673-9992/14/1/29 |
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