Marked elevation of circulating CD19+CD38hiCD24hi transitional B cells give protection against neonatal sepsis
Adequate functions of immunoregulation, mediated by regulatory cells such as IL-10 producing CD19+CD38hiCD24hi transitional B cells (Trans), play an important role in control of excessive inflammatory response. Yet, the role of Trans in neonatal sepsis is incompletely understood. We investigated the...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-06-01
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| Series: | Pediatrics and Neonatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957217302735 |
| _version_ | 1819161627199537152 |
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| author | Sitao Li Fei Ma Hu Hao Desheng Wang Yu Gao Jialiang Zhou Fei Li Hung-Chih Lin Xin Xiao Qiyi Zeng |
| author_facet | Sitao Li Fei Ma Hu Hao Desheng Wang Yu Gao Jialiang Zhou Fei Li Hung-Chih Lin Xin Xiao Qiyi Zeng |
| author_sort | Sitao Li |
| collection | DOAJ |
| description | Adequate functions of immunoregulation, mediated by regulatory cells such as IL-10 producing CD19+CD38hiCD24hi transitional B cells (Trans), play an important role in control of excessive inflammatory response. Yet, the role of Trans in neonatal sepsis is incompletely understood. We investigated the role of Trans in late-onset sepsis (LOS).
Methods: We used multicolor flow cytometry to analyse the phenotypes of B cells drawn from a cohort of 16 neonatal late-onset sepsis (LOS) (12 survivors and 4 non-survivors) and 20 healthy neonates over time.
Results: Patients undergone a serious decline of lymphocytes at the beginning of sepsis and then noticeable elevation during one week of follow-up had a good prognosis. Intriguingly, peripheral blood B cells, especially Trans, were the marked increase lymphocyte subset and maintained a high level of producing IL-10 during the 7 days of follow-up.
Conclusion: The level of IL-10 producing Trans was significantly elevated in peripheral blood of good prognosis newborns with LOS and might contribute to the successful immunoprotective state of the disease. |
| first_indexed | 2024-12-22T17:15:21Z |
| format | Article |
| id | doaj.art-fb35f55cf26343cd8f9001a41dc82501 |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-12-22T17:15:21Z |
| publishDate | 2018-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-fb35f55cf26343cd8f9001a41dc825012022-12-21T18:18:58ZengElsevierPediatrics and Neonatology1875-95722018-06-0159329630410.1016/j.pedneo.2017.10.005Marked elevation of circulating CD19+CD38hiCD24hi transitional B cells give protection against neonatal sepsisSitao Li0Fei Ma1Hu Hao2Desheng Wang3Yu Gao4Jialiang Zhou5Fei Li6Hung-Chih Lin7Xin Xiao8Qiyi Zeng9Department of Pediatrics, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Neonatology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaDepartment of Neonatology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaDepartment of Neonatology, The Fifth People's Hospital of Dongguan, Dongguan, ChinaDepartment of Obstetrics & Gynecology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaDepartment of Neonatal Surgery, Guangdong Women and Children Hospital, Guangzhou, ChinaDepartment of Neonatology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaDivision of Neonatology, China Medical University Children Hospital, Taichung, TaiwanDepartment of Neonatology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaDepartment of Pediatrics, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaAdequate functions of immunoregulation, mediated by regulatory cells such as IL-10 producing CD19+CD38hiCD24hi transitional B cells (Trans), play an important role in control of excessive inflammatory response. Yet, the role of Trans in neonatal sepsis is incompletely understood. We investigated the role of Trans in late-onset sepsis (LOS). Methods: We used multicolor flow cytometry to analyse the phenotypes of B cells drawn from a cohort of 16 neonatal late-onset sepsis (LOS) (12 survivors and 4 non-survivors) and 20 healthy neonates over time. Results: Patients undergone a serious decline of lymphocytes at the beginning of sepsis and then noticeable elevation during one week of follow-up had a good prognosis. Intriguingly, peripheral blood B cells, especially Trans, were the marked increase lymphocyte subset and maintained a high level of producing IL-10 during the 7 days of follow-up. Conclusion: The level of IL-10 producing Trans was significantly elevated in peripheral blood of good prognosis newborns with LOS and might contribute to the successful immunoprotective state of the disease.http://www.sciencedirect.com/science/article/pii/S1875957217302735IL-10late-onset sepsisneonatal immunitytransitional B cells |
| spellingShingle | Sitao Li Fei Ma Hu Hao Desheng Wang Yu Gao Jialiang Zhou Fei Li Hung-Chih Lin Xin Xiao Qiyi Zeng Marked elevation of circulating CD19+CD38hiCD24hi transitional B cells give protection against neonatal sepsis Pediatrics and Neonatology IL-10 late-onset sepsis neonatal immunity transitional B cells |
| title | Marked elevation of circulating CD19+CD38hiCD24hi transitional B cells give protection against neonatal sepsis |
| title_full | Marked elevation of circulating CD19+CD38hiCD24hi transitional B cells give protection against neonatal sepsis |
| title_fullStr | Marked elevation of circulating CD19+CD38hiCD24hi transitional B cells give protection against neonatal sepsis |
| title_full_unstemmed | Marked elevation of circulating CD19+CD38hiCD24hi transitional B cells give protection against neonatal sepsis |
| title_short | Marked elevation of circulating CD19+CD38hiCD24hi transitional B cells give protection against neonatal sepsis |
| title_sort | marked elevation of circulating cd19 cd38hicd24hi transitional b cells give protection against neonatal sepsis |
| topic | IL-10 late-onset sepsis neonatal immunity transitional B cells |
| url | http://www.sciencedirect.com/science/article/pii/S1875957217302735 |
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