An In Vivo Fluorescence Resonance Energy Transfer-Based Imaging Platform for Targeted Drug Discovery and Cancer Therapy

An In Vivo Fluorescence Resonance Energy Transfer-Based Imaging Platform for Targeted Drug Discovery and Cancer Therapy

In the present study, an efficient in vivo drug screening platform is established based on FRET technique. We transfected cancer cells with FRET-based caspase-3 (C3) sensor and validated the cell lines by detecting the change in FRET signal caused by the in vitro drug-induced cell apoptosis. Further...

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Bibliographic Details
Main Authors: Fuqiang Xing, Nana Ai, Shigao Huang, Cheng Jiang, Muhammad Jameel Mughal, Wei Ge, Guanyu Wang, Chu-Xia Deng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
apoptosis
cancer therapy
drug discovery
FRET technique
xenograft model
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.839078/full

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