Unbalanced production of LTB4/PGE2 driven by diabetes increases susceptibility to cutaneous leishmaniasis

Unbalanced production of LTB4/PGE2 driven by diabetes increases susceptibility to cutaneous leishmaniasis

ABSTRACTPoorly controlled diabetes mellitus leads to several comorbidities, including susceptibility to infections. Hyperglycemia increases phagocyte responsiveness, however immune cells from people with diabetes show inadequate antimicrobial functions. We and others have shown that aberrant product...

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Bibliographic Details
Main Authors: Icaro Bonyek-Silva, Sara Nunes, Reinan L. Santos, Filipe R. Lima, Alexsandro Lago, Juliana Silva, Lucas P. Carvalho, Sergio M. Arruda, Henrique C. Serezani, Edgar M. Carvalho, Claudia I. Brodskyn, Natalia M. Tavares
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Emerging Microbes and Infections
Subjects:
Diabetes
human leishmaniasis
Leishmania braziliensis
lipid mediators
LTB4
PGE2
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2020.1773744

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