One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic Acids
Palladium–catalyzed Suzuki cross-coupling of 2-aryl-4-chloro-3-iodoquinolines with excess arylboronic acids (2.5 equiv.) in the presence of tricyclohexylphosphine afforded the 2,3,4-triarylquinolines in one-pot operation. The incipient 2,3-diaryl-4-chloroquinolines were also prepared and transformed...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-10-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/15/10/7423/ |
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| author | Malose Jack Mphahlele Mamasegare Mabel Mphahlele |
| author_facet | Malose Jack Mphahlele Mamasegare Mabel Mphahlele |
| author_sort | Malose Jack Mphahlele |
| collection | DOAJ |
| description | Palladium–catalyzed Suzuki cross-coupling of 2-aryl-4-chloro-3-iodoquinolines with excess arylboronic acids (2.5 equiv.) in the presence of tricyclohexylphosphine afforded the 2,3,4-triarylquinolines in one-pot operation. The incipient 2,3-diaryl-4-chloroquinolines were also prepared and transformed to the primary 4-amino-2,3-diarylquinolines and 2,3-diarylquinolin-4(1H)-ones. |
| first_indexed | 2024-12-21T07:44:35Z |
| format | Article |
| id | doaj.art-fb3aa23b9a74417284996b297f6c8d86 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-21T07:44:35Z |
| publishDate | 2010-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-fb3aa23b9a74417284996b297f6c8d862022-12-21T19:11:14ZengMDPI AGMolecules1420-30492010-10-01151074237437One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic AcidsMalose Jack MphahleleMamasegare Mabel MphahlelePalladium–catalyzed Suzuki cross-coupling of 2-aryl-4-chloro-3-iodoquinolines with excess arylboronic acids (2.5 equiv.) in the presence of tricyclohexylphosphine afforded the 2,3,4-triarylquinolines in one-pot operation. The incipient 2,3-diaryl-4-chloroquinolines were also prepared and transformed to the primary 4-amino-2,3-diarylquinolines and 2,3-diarylquinolin-4(1H)-ones.http://www.mdpi.com/1420-3049/15/10/7423/2-aryl-4-chloro-3-iodoquinolinesSuzuki-Miyaura cross-coupling2,3-diaryl-4-chloroquinolines2,3,4-triarylquinolines |
| spellingShingle | Malose Jack Mphahlele Mamasegare Mabel Mphahlele One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic Acids Molecules 2-aryl-4-chloro-3-iodoquinolines Suzuki-Miyaura cross-coupling 2,3-diaryl-4-chloroquinolines 2,3,4-triarylquinolines |
| title | One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic Acids |
| title_full | One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic Acids |
| title_fullStr | One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic Acids |
| title_full_unstemmed | One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic Acids |
| title_short | One-Pot Synthesis of 2,3,4-Triarylquinolines via Suzuki-Miyaura Cross-Coupling of 2-Aryl-4-chloro-3-iodoquinolines with Arylboronic Acids |
| title_sort | one pot synthesis of 2 3 4 triarylquinolines via suzuki miyaura cross coupling of 2 aryl 4 chloro 3 iodoquinolines with arylboronic acids |
| topic | 2-aryl-4-chloro-3-iodoquinolines Suzuki-Miyaura cross-coupling 2,3-diaryl-4-chloroquinolines 2,3,4-triarylquinolines |
| url | http://www.mdpi.com/1420-3049/15/10/7423/ |
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