Stiffening of the nucleus pulposus upon axial loading of the intervertebral disc: An experimental in situ study
Mechanical loading is inherently related to the function and degeneration of the intervertebral disc. We present a series of experiments aimed at measuring the effect of a loading/unloading cycle of the intervertebral disc on the mechanical properties of the nucleus pulposus. The study relies on our...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-03-01
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| Series: | JOR Spine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jsp2.1005 |
| _version_ | 1818926412110757888 |
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| author | Steven V. Beekmans Kaj S. Emanuel Theodoor H. Smit Davide Iannuzzi |
| author_facet | Steven V. Beekmans Kaj S. Emanuel Theodoor H. Smit Davide Iannuzzi |
| author_sort | Steven V. Beekmans |
| collection | DOAJ |
| description | Mechanical loading is inherently related to the function and degeneration of the intervertebral disc. We present a series of experiments aimed at measuring the effect of a loading/unloading cycle of the intervertebral disc on the mechanical properties of the nucleus pulposus. The study relies on our new minimally invasive microindenter, which allows us to quantify the storage and loss moduli of the nucleus pulposus by inserting an optomechanical probe in an intact (resected) intervertebral disk through the annulus fibrosis via a small needle. Our results indicate that, under the influence of compressive loading, the nucleus pulposus exhibits a more solid‐like behavior. |
| first_indexed | 2024-12-20T02:56:42Z |
| format | Article |
| id | doaj.art-fb3aeae5f0d440c7858b770d4cf5d5b6 |
| institution | Directory Open Access Journal |
| issn | 2572-1143 |
| language | English |
| last_indexed | 2024-12-20T02:56:42Z |
| publishDate | 2018-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | JOR Spine |
| spelling | doaj.art-fb3aeae5f0d440c7858b770d4cf5d5b62022-12-21T19:55:54ZengWileyJOR Spine2572-11432018-03-0111n/an/a10.1002/jsp2.1005Stiffening of the nucleus pulposus upon axial loading of the intervertebral disc: An experimental in situ studySteven V. Beekmans0Kaj S. Emanuel1Theodoor H. Smit2Davide Iannuzzi3Department of Physics and Astronomy Vrije Universiteit Amsterdam Amsterdam NetherlandsDepartment of Orthopaedic Surgery VU University Medical Center (VUmc) Amsterdam NetherlandsDepartment of Medical Biology Academic Medical Center (AMC) Amsterdam NetherlandsDepartment of Physics and Astronomy Vrije Universiteit Amsterdam Amsterdam NetherlandsMechanical loading is inherently related to the function and degeneration of the intervertebral disc. We present a series of experiments aimed at measuring the effect of a loading/unloading cycle of the intervertebral disc on the mechanical properties of the nucleus pulposus. The study relies on our new minimally invasive microindenter, which allows us to quantify the storage and loss moduli of the nucleus pulposus by inserting an optomechanical probe in an intact (resected) intervertebral disk through the annulus fibrosis via a small needle. Our results indicate that, under the influence of compressive loading, the nucleus pulposus exhibits a more solid‐like behavior.https://doi.org/10.1002/jsp2.1005in situ viscoelastic propertiesintervertebral discmechanical loadingminimally invasive microindentationnucleus pulposus |
| spellingShingle | Steven V. Beekmans Kaj S. Emanuel Theodoor H. Smit Davide Iannuzzi Stiffening of the nucleus pulposus upon axial loading of the intervertebral disc: An experimental in situ study JOR Spine in situ viscoelastic properties intervertebral disc mechanical loading minimally invasive microindentation nucleus pulposus |
| title | Stiffening of the nucleus pulposus upon axial loading of the intervertebral disc: An experimental in situ study |
| title_full | Stiffening of the nucleus pulposus upon axial loading of the intervertebral disc: An experimental in situ study |
| title_fullStr | Stiffening of the nucleus pulposus upon axial loading of the intervertebral disc: An experimental in situ study |
| title_full_unstemmed | Stiffening of the nucleus pulposus upon axial loading of the intervertebral disc: An experimental in situ study |
| title_short | Stiffening of the nucleus pulposus upon axial loading of the intervertebral disc: An experimental in situ study |
| title_sort | stiffening of the nucleus pulposus upon axial loading of the intervertebral disc an experimental in situ study |
| topic | in situ viscoelastic properties intervertebral disc mechanical loading minimally invasive microindentation nucleus pulposus |
| url | https://doi.org/10.1002/jsp2.1005 |
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