MicroRNAs in Experimental Models of Movement Disorders
MicroRNAs (miRNAs) are small RNAs comprised of 20–25 nucleotides that regulates gene expression by inducing translational repression or degradation of target mRNA. The importance of miRNAs as a mediator of disease pathogenesis and therapeutic targets is rapidly emerging in neuroscience, as well as o...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Korean Movement Disorder Society
2011-10-01
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| Series: | Journal of Movement Disorders |
| Subjects: | |
| Online Access: | http://e-jmd.org/upload/jmd-4-2-55-1.pdf |
| _version_ | 1827842831400566784 |
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| author | Soon-Tae Lee Manho Kim |
| author_facet | Soon-Tae Lee Manho Kim |
| author_sort | Soon-Tae Lee |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are small RNAs comprised of 20–25 nucleotides that regulates gene expression by inducing translational repression or degradation of target mRNA. The importance of miRNAs as a mediator of disease pathogenesis and therapeutic targets is rapidly emerging in neuroscience, as well as oncology, immunology, and cardiovascular diseases. In Parkinson’s disease and related disorders, multiple studies have identified the implications of specific miRNAs and the polymorphisms of miRNA target genes during the disease pathogenesis. With a focus on Parkinson’s disease, spinocerebellar ataxia, hereditary spastic paraplegia, and Huntington’s disease, this review summarizes and interprets the observations, and proposes future research topics in this field. |
| first_indexed | 2024-03-12T08:15:25Z |
| format | Article |
| id | doaj.art-fb3b794086a04d01b03ab9b48d010293 |
| institution | Directory Open Access Journal |
| issn | 2005-940X 2093-4939 |
| language | English |
| last_indexed | 2024-03-12T08:15:25Z |
| publishDate | 2011-10-01 |
| publisher | Korean Movement Disorder Society |
| record_format | Article |
| series | Journal of Movement Disorders |
| spelling | doaj.art-fb3b794086a04d01b03ab9b48d0102932023-09-02T18:56:17ZengKorean Movement Disorder SocietyJournal of Movement Disorders2005-940X2093-49392011-10-0142555910.14802/jmd.1101130MicroRNAs in Experimental Models of Movement DisordersSoon-Tae LeeManho KimMicroRNAs (miRNAs) are small RNAs comprised of 20–25 nucleotides that regulates gene expression by inducing translational repression or degradation of target mRNA. The importance of miRNAs as a mediator of disease pathogenesis and therapeutic targets is rapidly emerging in neuroscience, as well as oncology, immunology, and cardiovascular diseases. In Parkinson’s disease and related disorders, multiple studies have identified the implications of specific miRNAs and the polymorphisms of miRNA target genes during the disease pathogenesis. With a focus on Parkinson’s disease, spinocerebellar ataxia, hereditary spastic paraplegia, and Huntington’s disease, this review summarizes and interprets the observations, and proposes future research topics in this field.http://e-jmd.org/upload/jmd-4-2-55-1.pdfMicroRNAParkinson’s diseaseSpinocerebellar ataxiaHereditary spastic paraplegiaHuntington’s disease |
| spellingShingle | Soon-Tae Lee Manho Kim MicroRNAs in Experimental Models of Movement Disorders Journal of Movement Disorders MicroRNA Parkinson’s disease Spinocerebellar ataxia Hereditary spastic paraplegia Huntington’s disease |
| title | MicroRNAs in Experimental Models of Movement Disorders |
| title_full | MicroRNAs in Experimental Models of Movement Disorders |
| title_fullStr | MicroRNAs in Experimental Models of Movement Disorders |
| title_full_unstemmed | MicroRNAs in Experimental Models of Movement Disorders |
| title_short | MicroRNAs in Experimental Models of Movement Disorders |
| title_sort | micrornas in experimental models of movement disorders |
| topic | MicroRNA Parkinson’s disease Spinocerebellar ataxia Hereditary spastic paraplegia Huntington’s disease |
| url | http://e-jmd.org/upload/jmd-4-2-55-1.pdf |
| work_keys_str_mv | AT soontaelee micrornasinexperimentalmodelsofmovementdisorders AT manhokim micrornasinexperimentalmodelsofmovementdisorders |