Single anthocyanins effectiveness modulating inflammation markers in obesity: dosage and matrix composition analysis
Anthocyanins (ACNs) are phytochemicals with numerous bioactivities, e.g., antioxidant and anti-inflammatory. Health benefits from consuming ACN-rich foods, extracts, and supplements have been studied in clinical trials (CT). However, the individual effect of single ACNs and their correlation with do...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1255518/full |
| _version_ | 1797641864619229184 |
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| author | Jorge Alberto Fragoso-Medina Jorge Alberto Fragoso-Medina Selma Romina López Vaquera Selma Romina López Vaquera Astrid Domínguez-Uscanga Astrid Domínguez-Uscanga Diego Luna-Vital Diego Luna-Vital Noemí García Noemí García Noemí García |
| author_facet | Jorge Alberto Fragoso-Medina Jorge Alberto Fragoso-Medina Selma Romina López Vaquera Selma Romina López Vaquera Astrid Domínguez-Uscanga Astrid Domínguez-Uscanga Diego Luna-Vital Diego Luna-Vital Noemí García Noemí García Noemí García |
| author_sort | Jorge Alberto Fragoso-Medina |
| collection | DOAJ |
| description | Anthocyanins (ACNs) are phytochemicals with numerous bioactivities, e.g., antioxidant and anti-inflammatory. Health benefits from consuming ACN-rich foods, extracts, and supplements have been studied in clinical trials (CT). However, the individual effect of single ACNs and their correlation with doses and specific bioactivities or molecular targets have not been thoroughly analyzed. This review shows a recompilation of single anthocyanins composition and concentrations used in CT, conducted to investigate the effect of these anti-inflammatory derivatives in obese condition. Single anthocyanin doses with changes in the levels of frequently monitored markers were correlated. In addition, the analysis was complemented with reports of studies made in vitro with single ACNs. Anthocyanins' efficacy in diseases with high baseline obesity-related inflammation markers was evidenced. A poor correlation was found between most single anthocyanin doses and level changes of commonly monitored markers. Correlations between cyanidin, delphinidin, and pelargonidin derivatives and specific molecular targets were proposed. Our analysis showed that knowledge of specific compositions and anthocyanin concentrations determined in future studies would provide more information about mechanisms of action. |
| first_indexed | 2024-03-11T13:51:46Z |
| format | Article |
| id | doaj.art-fb3d3335dec54c1abb09fef762aa563e |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-11T13:51:46Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-fb3d3335dec54c1abb09fef762aa563e2023-11-02T09:07:04ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-11-011010.3389/fnut.2023.12555181255518Single anthocyanins effectiveness modulating inflammation markers in obesity: dosage and matrix composition analysisJorge Alberto Fragoso-Medina0Jorge Alberto Fragoso-Medina1Selma Romina López Vaquera2Selma Romina López Vaquera3Astrid Domínguez-Uscanga4Astrid Domínguez-Uscanga5Diego Luna-Vital6Diego Luna-Vital7Noemí García8Noemí García9Noemí García10Institute for Obesity Research, Tecnologico de Monterrey, Monterrey, MexicoSchool of Medicine and Health Sciences, Tecnologico de Monterrey, Monterrey, MexicoInstitute for Obesity Research, Tecnologico de Monterrey, Monterrey, MexicoSchool of Medicine and Health Sciences, Tecnologico de Monterrey, Monterrey, MexicoInstitute for Obesity Research, Tecnologico de Monterrey, Monterrey, MexicoSchool of Engineering and Sciences, Tecnologico de Monterrey, Monterrey, MexicoInstitute for Obesity Research, Tecnologico de Monterrey, Monterrey, MexicoSchool of Engineering and Sciences, Tecnologico de Monterrey, Monterrey, MexicoInstitute for Obesity Research, Tecnologico de Monterrey, Monterrey, MexicoSchool of Medicine and Health Sciences, Tecnologico de Monterrey, Monterrey, MexicoPreclinical Research Unit, Tecnologico de Monterrey, Monterrey, MexicoAnthocyanins (ACNs) are phytochemicals with numerous bioactivities, e.g., antioxidant and anti-inflammatory. Health benefits from consuming ACN-rich foods, extracts, and supplements have been studied in clinical trials (CT). However, the individual effect of single ACNs and their correlation with doses and specific bioactivities or molecular targets have not been thoroughly analyzed. This review shows a recompilation of single anthocyanins composition and concentrations used in CT, conducted to investigate the effect of these anti-inflammatory derivatives in obese condition. Single anthocyanin doses with changes in the levels of frequently monitored markers were correlated. In addition, the analysis was complemented with reports of studies made in vitro with single ACNs. Anthocyanins' efficacy in diseases with high baseline obesity-related inflammation markers was evidenced. A poor correlation was found between most single anthocyanin doses and level changes of commonly monitored markers. Correlations between cyanidin, delphinidin, and pelargonidin derivatives and specific molecular targets were proposed. Our analysis showed that knowledge of specific compositions and anthocyanin concentrations determined in future studies would provide more information about mechanisms of action.https://www.frontiersin.org/articles/10.3389/fnut.2023.1255518/fullantioxidantsanti-inflammatoriesanthocyanins bioactivitiesanthocyanins compositionsingle anthocyanins dosesinflammation markers |
| spellingShingle | Jorge Alberto Fragoso-Medina Jorge Alberto Fragoso-Medina Selma Romina López Vaquera Selma Romina López Vaquera Astrid Domínguez-Uscanga Astrid Domínguez-Uscanga Diego Luna-Vital Diego Luna-Vital Noemí García Noemí García Noemí García Single anthocyanins effectiveness modulating inflammation markers in obesity: dosage and matrix composition analysis Frontiers in Nutrition antioxidants anti-inflammatories anthocyanins bioactivities anthocyanins composition single anthocyanins doses inflammation markers |
| title | Single anthocyanins effectiveness modulating inflammation markers in obesity: dosage and matrix composition analysis |
| title_full | Single anthocyanins effectiveness modulating inflammation markers in obesity: dosage and matrix composition analysis |
| title_fullStr | Single anthocyanins effectiveness modulating inflammation markers in obesity: dosage and matrix composition analysis |
| title_full_unstemmed | Single anthocyanins effectiveness modulating inflammation markers in obesity: dosage and matrix composition analysis |
| title_short | Single anthocyanins effectiveness modulating inflammation markers in obesity: dosage and matrix composition analysis |
| title_sort | single anthocyanins effectiveness modulating inflammation markers in obesity dosage and matrix composition analysis |
| topic | antioxidants anti-inflammatories anthocyanins bioactivities anthocyanins composition single anthocyanins doses inflammation markers |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1255518/full |
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